19 resultados para Golden Retriever

em Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland


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Digitoitu 19. 9. 2008.

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kuv., 22 x 28 cm

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Tässä insinöörityössä vertaillaan fyysisten koneiden konsolidointitekniikoita ja perehtyy tarkemmin Vmware ESX Server 2.5 -arkkitehtuuriin. Konsolidointimenetelmistä käsitellään: palveluiden keskittäminen, fyysinen konsolidointi, tietojen integrointi sekä sovellusten integrointi. Virtuaalijärjestelmistä vertailtiin markkinoiden yleisimmin käytössä olevat tuotteet. Vertailuun otettiin Vmwaren ESX sekä Server -tuote. Vastaavasti Microsoftilta valittiin tuote Virtual Server 2005. Projektissa toteutettiin Vmware ESX 2.5 -järjestelmän asennus sekä konfigurointi. Järjestelmään luotiin standardi virtuaalikoneita varten sekä määriteltiin Golden master -levykuva. Varsinaisessa konsolidointiosuudessa toteutettiin fyysisten laitteiden keskittämistä ja virtualisointia. Kohteena oli NT4-toimialue, tiedosto, tulostus, Exchange Outlook Web Access, Exchange 5.5 -tietokanta sekä SMTP -palvelimen siirto VMware ESX -järjestelmään. Työn lopputuloksean saavutettiin toimiva virtuaali-infrastruktuuri, johon voidaan tarvittaessa helposti luoda virtuaalikoneita.

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Summary: Pectinate ligament dysplasia and glaucoma in Labrador Retriever

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Kirjallisuusarvostelu

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Traditionally simulators have been used extensively in robotics to develop robotic systems without the need to build expensive hardware. However, simulators can be also be used as a “memory”for a robot. This allows the robot to try out actions in simulation before executing them for real. The key obstacle to this approach is an uncertainty of knowledge about the environment. The goal of the Master’s Thesis work was to develop a method, which allows updating the simulation model based on actual measurements to achieve a success of the planned task. OpenRAVE was chosen as an experimental simulation environment on planning,trial and update stages. Steepest Descent algorithm in conjunction with Golden Section search procedure form the principle part of optimization process. During experiments, the properties of the proposed method, such as sensitivity to different parameters, including gradient and error function, were examined. The limitations of the approach were established, based on analyzing the regions of convergence.

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The golden standard in nuclear medicine imaging of inflammation is the use of radiolabeled leukocytes. Although their diagnostic accuracy is good, the preparation of the leukocytes is both laborious and potentially hazardous for laboratory personnel. Molecules involved in leukocyte migration could serve as targets for the development of inflammation imaging agents. An excellent target would be a molecule that is absent or expressed at low level in normal tissues, but is induced or up-regulated at the site of inflammation. Vascular adhesion protein-1 (VAP-1) is a very promising target for in vivo imaging, since it is translocated to the endothelial cell surface when inflammation occurs. VAP-1 functions as an endothelial adhesion molecule that participates in leukocyte recruitment to inflamed tissues. Besides being an adhesion molecule, VAP-1 also has enzymatic activity. In this thesis, the targeting of VAP-1 was studied by using Gallium-68 (68Ga) labeled peptides and an Iodine-124 (124I) labeled antibody. The peptides were designed based on molecular modelling and phage display library searches. The new imaging agents were preclinically tested in vitro, as well as in vivo in animal models. The most promising imaging agent appeared to be a peptide belonging to the VAP-1 leukocyte ligand, Siglec-9 peptide. The 68Ga-labeled Siglec-9 peptide was able to detect VAP-1 positive vasculature in rodent models of sterile skin inflammation and melanoma by positron emission tomography. In addition to peptides, the 124I-labeled antibody showed VAP-1 specific binding both in vitro and in vivo. However, the estimated human radiation dose was rather high, and thus further preclinical studies in disease models are needed to clarify the value of this imaging agent. Detection of VAP-1 on endothelium was demonstrated in these studies and this imaging approach could be used in the diagnosis of inflammatory conditions as well as melanoma. These studies provide a proof-of-concept for PET imaging of VAP-1 and further studies are warranted.

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Kirjallisuusarvostelu

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Kirjallisuusarvostelu

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The purpose of this this study is to examine the effects that a celebrity CEO’s crisis communication has on the crisis outcome and further on the quick decision response, resource mobilization and information flow during a crisis. The research was conducted using a multiple embedded case method, with four cases that represent different kinds of crisis that have all involved a celebrity CEO. The cases have been collected from various secondary data sources. The results of the study indicate that in crisis situations the celebrity CEO is expected to take responsibility of the crisis communication. The CEO needs to understand how and what to communicate in these situations and they need to make quick decisions even with limited information available. Crisis outcome is highly dependent on the golden hour crisis communication and there the performance of the celebrity CEO is crucial.

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Kirjallisuusarvostelu