Potentiometric titration as a method of determining the stoichiometric dissociation constants of weak acids from the thermodynamic dissociation constants of aqueous solutions at 298.15 K

The simple single-ion activity coefficient equation originating from the Debye-Hückel theory was used to determine the thermodynamic and stoichiometric dissociation constants of weak acids from data concerning galvanic cells. Electromotive force data from galvanic cells without liquid junctions, which was obtained from literature, was studied in conjuction with the potentiometric titration data relating to aqueous solutions at 298.15 K. The dissociation constants of weak acids could be determined by the presented techniques and almost all the experimental data studied could be interpreted within the range of experimental error. Potentiometric titration has been used here and the calculation methods were developed to obtain the thermodynamic and stoichiometric dissociation constants of some weak acids in aqueous solutions at 298.15 K. The ionic strength of titrated solutions were adjusted using an inert electrolyte, namely, sodium or potassium chloride. Salt content alonedetermines the ionic strength. The ionic strength of the solutions studied varied from 0.059 mol kg-1 to 0.37 mol kg-1, and in some cases up to 1.0 mol kg-1. The following substances were investigated using potentiometric titration: aceticacid, propionic acid, L-aspartic acid, L-glutamic acid and bis(2,2-dimethyl-3-oxopropanol) amine.

Knowledge Sharing between Generations in an Organisation - Retention of the Old or Building the New?

The study explores knowledge transfer between retiring employees and their successors in expert work. My aim is to ascertain whether there is knowledge development or building new knowledge related to this organisational knowledge transfer between generations; in other words, is the transfer of knowledge from experienced, retiring employees to their successors merely retention of the existing organisational knowledge by distributing it from one individual to another or does this transfer lead to building new and meaningful organisational knowledge. I call knowledge transfer between generations and the possibly related knowledge building in this study knowledge sharing between generations. The study examines the organisation and knowledge management from a knowledge-based and constructionist view. From this standpoint, I see knowledge transfer as an interactive process, and the exploration is based on how the people involved in this process understand and experience the phenomenon studied. The research method is organisational ethnography. I conducted the analysis of data using thematic analysis and the articulation method, which has not been used before in organisational knowledge studies. The primary empirical data consists of theme interviews with twelve employees involved in knowledge transfer in the organisation being studied and five follow-up theme interviews. Six of the interviewees are expert duty employees due to retire shortly, and six are their successors. All those participating in the follow-up interviews are successors of those soon to retire from their expert responsibilities. The organisation in the study is a medium-sized Finnish firm, which designs and manufactures electrical equipment and systems for the global market. The results of the study show that expert work-related knowledge transfer between generations can mean knowledge building which produces new, meaningful knowledge for the organisation. This knowledge is distributed in the organisation to all those that find it useful in increasing the efficiency and competitiveness of the whole organisation. The transfer and building of knowledge together create an act of knowledge sharing between generations where the building of knowledge presupposes transfer. Knowledge sharing proceeds between the expert and the novice through eight phases. During the phases of knowledge transfer the expert guides the novice to absorb the knowledge to be transferred. With the expert’s help the novice gradually comes to understand the knowledge and in the end he or she is capable of using it in his or her work. During the phases of knowledge building the expert helps the novice to further develop the knowledge being transferred so that it becomes new, useful knowledge for the organisation. After that the novice takes the built knowledge to use in his or her work. Based on the results of the study, knowledge sharing between generations takes place in interaction and ends when knowledge is taken to use. The results I obtained in the interviews by the articulation method show that knowledge sharing between generations is shaped by the novices’ conceptions of their own work goals, knowledge needs and duties. These are not only based on the official definition of the work, but also how the novices find their work or how they prioritise the given objectives and responsibilities. The study shows that the novices see their work primarily as maintenance or development. Those primarily involved in maintenance duties do not necessarily need knowledge defined as transferred between generations. Therefore, they do not necessarily transfer knowledge with their assigned experts, even though this can happen in favourable circumstances. They do not build knowledge because their view of their work goals and duties does not require the building of new knowledge. Those primarily involved in development duties, however, do need knowledge available from their assigned experts. Therefore, regardless of circumstances they transfer knowledge with their assigned experts and also build knowledge because their work goals and duties create a basis for building new knowledge. The literature on knowledge transfer between generations has focused on describing either the knowledge being transferred or the means by which it is transferred. Based on the results of this study, however, knowledge sharing between generations, that is, transfer and building is determined by how the novice considers his or her own knowledge needs and work practices. This is why studies on knowledge sharing between generations and its implementation should be based not only on the knowledge content and how it is shared, but also on the context of the work in which the novice interprets and shares knowledge. The existing literature has not considered the possibility that knowledge transfer between generations may mean building knowledge. The results of this study, however, show that this is possible. In knowledge building, the expert’s existing organisational knowledge is combined with the new knowledge that the novice brings to the organisation. In their interaction this combination of the expert’s “old” and the novice’s “new” knowledge becomes new, meaningful organisational knowledge. Previous studies show that knowledge development between the members of an organisation is the prerequisite for organisational renewal which in turn is essential for improved competitiveness. Against this background, knowledge building enables organisational renewal and thus enhances competitiveness. Hence, when knowledge transfer between generations is followed by knowledge building, the organisation kills two birds with one stone. In knowledge transfer the organisation retains the existing knowledge and thus maintains its competitiveness. In knowledge building the organisation developsnew knowledge and thus improves its competitiveness.

8/2010 Kantatien 51 Kirkkonummi-Kivenlahti vaikutusselvitys

Tässä työssä on arvioitu moottoritieksi rakenteilla olevan kantatie 51 Kirkkonummi-Kivenlahti-tieosuuden vaikutuksia liikenteeseen sekä alueen kehitykseen. Työssä käytetyt aineistot koostuvat yleisesti saatavilla olevista tilastoista ja rekistereistä. Lisäksi toteutuneita ja odotettavissa olevia vaikutuksia on selvitetty kunta- ja yrityshaastattelujen avulla. Nyt toteutetussa ennen-vaiheessa havaittuja hankkeen orastavia vaikutuksia sekä moottoritieyhteyteen liittyviä odotuksia on nostettu esiin. Ennen-vaiheen tiedonkeruu muodostaa jälkeen-vaiheen vaikutusarvioinnin rungon. Varsinaiset johtopäätökset voidaan tuottaa jäkeen-vaiheen vaikutusarvioinnin yhteydessä. Ympäristövaikutukset on jätetty tarkastelun ulkopuolelle. Moottoritieyhteyden valmistumisen myötä liikenteen sujuvuus, turvallisuus ja ajomukavuus paranevat etenkin liittymissä. Nopeutuva ja sujuvoituva liikenneyhteys helpottaa etenkin tien länsiosien asukkaiden autoillen tapahtuvaa työssäkäyntiä pääkaupunkiseudulla ja lisää asiointia tien varren keskuksissa. Myös etenkin viikonloppuisin tapahtuva mökki- ja muu vapaa-ajanliikenne hyötyy merkittävästi tien paranemisesta. Yritysasiointi ja muut lyhytkestoiset pistäytymiset autolla pääkaupunkiseudun ja tarkastelualueen länsiosan välillä sujuvoituvat matka-aikojen muuttuessa nopeammiksi ja helpommin ennustettaviksi. Nämä hyödyt koskevat myös raskasta liikennettä ja muita kuljetuksia. Moottoritien valmistuminen Kirkkonummenja Kivenlahden välille parantaa linja-autoliikenteen liikennöintiolosuhteita. Merkittävintä on täsmällisyyden lisääntyminen ruuhkien vähentyessä sekä tielle liittymisen helpottuessa. Lisäksi tien tuoma hienoinen matka-aikojen lyhentyminen synnyttää myös suoria aikasäästöjä. Moottoritie parantaa suhteellisesti eniten henkilöautoliikenteen sujuvuutta, ja ilman muita toimenpiteitä tämä saattaa johtaa joukkoliikenteen kulkutapaosuuden supistumiseen. Moottoritieyhteys lisää muuttoliikettä tienvarteen liikenteellisesti ja asuinympäristöltään edullisille alueille. Jo tien rakentamispäätös on vaikuttanut tienvarsialueen houkuttelevuuteen asuinpaikkana. Tarkastelualueen kuntien nettomuutto on ollut koko 2000-luvun selvästi positiivinen. Väestönkasvu on ollut joka kunnassa 1-3 % vuodessa. Voimakas muuttoliike luo kuitenkin ankariakin paineita kuntatalouteen palvelutarjonnan ja kunnallistekniikan lisäystarpeen vuoksi. Alueen kunnissa pientalojen hinnannousut ovat olleet suhteellisen säännönmukaisia. Kantatie 51 muodostaa alueellisesti merkittävän kehityskäytävän, jonka maankäyttöä tien parantamisen viivästyminen on rajoittanut lähinnä Kirkkonummen alueella. Tien tuntumassa on käynnissä lukuisia kaavoitushankkeita, joiden tavoitteena on keskittää asutusta ja yritystoimintaa tien ja rantaradan muodostamaan kehityskäytävään. Espoossa Länsiväylän varren työpaikka-alueen odotetaan täydentyvän moottoritien jatkamisen myötä. Siuntiossa ja Inkoossa kaavoituksella osoitetaan lisää maankäyttöä tien tuntumaan. Haastatelluissa yrityksissä tien parantamista pidetään myönteisenä, imagoa parantavana ja toimintaoloja helpottavana kehityksenä. Etenkin niiden yritysten, joilla on kiinteät yhteydet pääkaupunkiseutuun, toimintaedellytykset paranevat liikkumisen nopeutumisen ja asioinnin helpottumisen myötä. Kuljetuksia helpottaa etenkin liittymien parantaminen ja matka-aikojen ennakoitavuus. Kaupan edellytykset paranevat etenkin Kirkkonummella, jonne on suunnitteilla tilaa vievän kaupan yksiköitä. Lisäksi tieyhteyden parantamisella odotetaan olevan myönteinen vaikutus matkailu- ja vapaa-ajan palvelujen kuten retkeily-, golf- ja veneilymahdollisuuksien kysyntään.

Factors predicting mortality in type 2 diabetes. With special reference to physical exercise, blood pressure, proteinuria, inflammation and P wave duration

Background: Type 2 diabetes patients have a 2-4 fold risk of cardiovascular disease (CVD) compared to the general population. In type 2 diabetes, several CVD risk factors have been identified, including obesity, hypertension, hyperglycemia, proteinuria, sedentary lifestyle and dyslipidemia. Although much of the excess CVD risk can be attributed to these risk factors, a significant proportion is still unknown. Aims: To assess in middle-aged type 2 diabetic subjects the joint relations of several conventional and non-conventional CVD risk factors with respect to cardiovascular and total mortality. Subjects and methods: This thesis is part of a large prospective, population based East-West type 2 diabetes study that was launched in 1982-1984. It includes 1,059 middle-aged (45-64 years old) participants. At baseline, a thorough clinical examination and laboratory measurements were performed and an ECG was recorded. The latest follow-up study was performed 18 years later in January 2001 (when the subjects were 63-81 years old). The study endpoints were total mortality and mortality due to CVD, coronary heart disease (CHD) and stroke. Results: Physically more active patients had significantly reduced total, CVD and CHD mortality independent of high-sensitivity C-reactive protein (hs-CRP) levels unless proteinuria was present. Among physically active patients with a hs-CRP level >3 mg/L, the prognosis of CVD mortality was similar to patients with hs-CRP levels ≤3 mg/L. The worst prognosis was among physically inactive patients with hs-CRP levels >3 mg/L. Physically active patients with proteinuria had significantly increased total and CVD mortality by multivariate analyses. After adjustment for confounding factors, patients with proteinuria and a systolic BP <130 mmHg had a significant increase in total and CVD mortality compared to those with a systolic BP between 130 and 160 mmHg. The prognosis was similar in patients with a systolic BP <130 mmHg and ≥160 mmHg. Among patients without proteinuria, a systolic BP <130 mmHg was associated with a non-significant reduction in mortality. A P wave duration ≥114 ms was associated with a 2.5-fold increase in stroke mortality among patients with prevalent CHD or claudication. This finding persisted in multivariable analyses. Among patients with no comorbidities, there was no relationship between P wave duration and stroke mortality. Conclusions: Physical activity reduces total and CVD mortality in patients with type 2 diabetes without proteinuria or with elevated levels of hs-CRP, suggesting that the anti-inflammatory effect of physical activity can counteract increased CVD morbidity and mortality associated with a high CRP level. In patients with proteinuria the protective effect was not, however, present. Among patients with proteinuria, systolic BP <130 mmHg may increase mortality due to CVD. These results demonstrate the importance of early intervention to prevent CVD and to control all-cause mortality among patients with type 2 diabetes. The presence of proteinuria should be taken into account when defining the target systolic BP level for prevention of CVD deaths. A prolongation of the duration of the P wave was associated with increased stroke mortality among high-risk patients with type 2 diabetes. P wave duration is easy to measure and merits further examination to evaluate its importance for estimation of the risk of stroke among patients with type 2 diabetes.