Interaction on the Page: Paratexts in two manuscripts of the Middle English Polychronicon

Tutkimuksessani tarkastelen myöhäiskeskiaikaisen maailmanhistoriateoksen, Ranulph Higdenin Polychroniconin, materiaalisia ilmentymiä. Vertailuun valittiin kaksi käsikirjoitusta, jotka sisältävät John Trevisan keskienglanninkielisen käännöksen kyseisestä teoksesta. Tutkielman lähtökohtana on ajatus, jonka mukaan käsikirjoitusten ja painettujen kirjojen välisistä eroista huolimatta myös ensin mainittuja voidaan tutkia kirjoina eli lukijan kohtaamina fyysisinä esineinä, jotka sisältävät varsinaisen tekstin lisäksi tekstuaalisia ja visuaalisia elementtejä, joilla tekstiä jäsennellään ja esitellään lukijalle ja jotka vaikuttavat lukijan lukukokemukseen ja ohjaavat lukuprosessia. Näiden elementtien kuvaamiseen ja analysointiin olen soveltanut Gérard Genetten parateksti-käsitettä, jonka käyttö käsikirjoitusten tutkimuksessa on toistaiseksi ollut vähäistä. Tutkielman tavoitteena on historiallisen pragmatiikan mukaisesti ottaa huomioon tekstien fyysinen ja sosiaalinen konteksti. Näkökulma painottuu vuorovaikutukseen kirjan tuottajien ja sen lukijoiden välillä, ja tutkielman tarkoitus on paitsi selvittää, millaisia elementtejä käsikirjoituksista löytyy lukijan lukuprosessia ohjaamaan ja tukemaan, myös tarkastella lukijoiden itsensä tekemiä merkintöjä. Tutkimustulokset osoittavat, että lukijoiden merkinnät noudattelivat osin samoja muotoja ja käyttötarkoituksia kuin kirjurien valmiiksi täydentämät elementit (esim. glossat) käsikirjoituksissa, mutta joitakin elementtejä täydennettiin mahdollisesti myös painettujen kirjojen myötä yleistyneiden käytäntöjen pohjalta. Analyysissani tarkastelen lähemmin myös teokseen liitettyjä esipuheita ja muita tekstejä tarkoituksenani selvittää, mitkä niistä voidaan luokitella parateksteiksi ja mikä merkitys niillä on kokonaisuuden kannalta. Tutkimuksessa kävi ilmi, että tekijän ja kääntäjän esipuheista löytyivät kaikki Genetten määrittämät kriteerit, kun taas aineiston toiseen käsikirjoitukseen sisältyvät muiden kirjoittajien tekstit eivät ole luokiteltavissa parateksteiksi, vaikka ne ulkoisesti sellaisilta vaikuttavat ja vaikka niistä on tullut paratekstien kaltainen kiinteä osa Polychroniconia.

Stromal interaction molecule 1 and its role in the regulation, proliferation and protein expression in follicular ML-1 thyroid cancer cells

Calcium (Ca2+) is involved in the regulation of variety of cellular functions including hallmarks of cancer development such as cellular migration and cellular proliferation. Store-operated calcium entry (SOCE) is a central mechanism in cellular calcium signaling and in maintaining the cellular calcium balance. Stromal interaction molecule 1(STIM1) has been identified as an important constituent of SOCE. In this thesis , the STIM1 proteins are studied for their importance in cellular processes and their effects on the expression of S1P1, S1P2, S1P3, VEGFR-2, and TRPC-1 in follicular ML-1 thyroid cancer cells. The results show the importance of STIM1 proteins in SOCE in these cells. The SOCE is significantly reduced in the STIM1 knockdown cells. The results also show the importance of STIM1 proteins in the expression of S1P2 and VEGFR-2 in these cells, as knockdown of STIM1 was shown to upregulate the expression of S1P2 and VEGFR-2. The migration and proliferation is also considerably reduced in the cells in which STIM1 has been knocked down showing the significance of STIM1 in the migration and proliferation in these cells.

Integrated reporting – a new form of a firm’s interaction with stakeholders

This study examines a new kind of public reporting, called integrated reporting as a form of a firm’s interaction with stakeholders. The study concerned issues such as how the studied organization defined its stakeholders and how this definition evolved during the transition period from 2009 to 2013, how has the integrated reporting of the organization evolved as an instrument of interaction with stakeholders over the transition period, and how the organization reported its value creation according to the international integrated reporting framework in the final, full-featured report. In examining the theory, the study used a qualitative analysis method that allowed deriving conceptual tools necessary to carry out the study. This study is based on the material of the five integrated reports written in Russian from a subsidiary of a Russian public company. The subsidiary carried out the transition to an integrated reporting for the five years from 2009 to 2013. A comparative qualitative method was used in reviewing the empirical material. During the research, an active cooperation of the organization with key stakeholders was revealed, which occurred during the whole period of development of integrated reporting. As a result, integrated reports were produced in cooperation with various key stakeholders, allowing balancing the financial and non-financial information in the reports. The study found that during the transition period, integrated reports gradually changed in the direction of greater clarity and ease of access to perception, consistency of presentation and materiality. The integrated reporting of the organization began reflect the basic requirements of the international integrated reporting framework regarding the content elements and guiding principles. Thus, the organization’s reports began including features of financial and non-financial reporting and connecting the three aspects of the organization's activities: economic, environmental and social. This study reveals the importance of identifying key stakeholders and their influence on the creation of organizational value. The new form of reporting suits better the requirements of modern organizations to interact with their stakeholder groups. The integrated reporting, which reflects the principles of the international integrated reporting framework, is an active resource for companies to communicate with stakeholders and a platform of transmission the necessary information on the creation of value in the long term.

Parameter estimation for Chaotic or Stochastic Dynamics

Since its discovery, chaos has been a very interesting and challenging topic of research. Many great minds spent their entire lives trying to give some rules to it. Nowadays, thanks to the research of last century and the advent of computers, it is possible to predict chaotic phenomena of nature for a certain limited amount of time. The aim of this study is to present a recently discovered method for the parameter estimation of the chaotic dynamical system models via the correlation integral likelihood, and give some hints for a more optimized use of it, together with a possible application to the industry. The main part of our study concerned two chaotic attractors whose general behaviour is diff erent, in order to capture eventual di fferences in the results. In the various simulations that we performed, the initial conditions have been changed in a quite exhaustive way. The results obtained show that, under certain conditions, this method works very well in all the case. In particular, it came out that the most important aspect is to be very careful while creating the training set and the empirical likelihood, since a lack of information in this part of the procedure leads to low quality results.