3 resultados para INHIBIDORES DE CAPTACIÓN DE SEROTONINA - ADMINISTRACIÓN


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Ponencia a la mesa Definicin y funciones de la Enfermera de Urgencias y Emergencias prehospitalarias. XIII Congreso Nacional de la Sociedad Espaola de Enfermera de Urgencias y Emergencias (SEEUE). Vdeos disponibles en: https://vimeo.com/21043097

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The administration of selective serotonin reuptake inhibitors (SSRIs) typically used as antidepressants increases alcohol consumption after an alcohol deprivation period in rats. However, the appearance of this effect after the treatment with selective noradrenaline reuptake inhibitors (SNRIs) has not been studied. In the present work we examined the effects of a 15-d treatment with the SNRI atomoxetine (1, 3 and 10mg/kg, i.p.) in male rats trained to drink alcohol solutions in a 4-bottle choice test. The treatment with atomoxetine (10mg/kg, i.p.) during an alcohol deprivation period increased alcohol consumption after relapse. This effect only lasted one week, disappearing thereafter. Treatment with atomoxetine did not cause a behavioral sensitized response to a challenge dose of amphetamine (1.5mg/kg, i.p.), indicating the absence of a supersensitive dopaminergic transmission. This effect is markedly different from that of SSRI antidepressants that produced both long-lasting increases in alcohol consumption and behavioral sensitization. Clinical implications are discussed.

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Esta Estrategia andaluza fue reconocida en 2013 con el Premio Nacional en el mbito Laboral en la sexta edicin de la estrategia NAOS que organiza el Ministerio de Sanidad, Servicios Sociales e Igualdad. Publicado en la pgina Web de la Consejera de Salud (Ciudadana / Inicio / Nuestra Salud / Vida sana / Promocin de la Salud en el Lugar de Trabajo / Salud en el trabajo +info)