How to Read Bible stories

A welcome supplement to the bestselling How to Read the OT and How to Read the NT, indicating more recent developments in biblical studies especially in the area of narrative criticism.

Promoting Corporate Responsibility in Private Banking: Necessary and Sufficient Conditions for Joining the Wolfsberg Initiative Against Money Laundering

In recent years, the fight against money laundering has emerged as a key issue of financial regulation. The Wolfsberg Group is an important multistakeholder agreement establishing corporate responsibility (CR) principles against money laundering in a domain where international coordination remains otherwise difficult. The fact that 10 out of the 25 top private banking institutions joined this initiative opens up an interesting puzzle concerning the conditions for the participation of key industry players in the Wolfsberg Group. The article presents a fuzzy-set analysis of seven hypotheses based on firm-level organizational factors, the macro-institutional context, and the regulatory framework. Results from the analysis of these 25 financial institutions show that public ownership of the bank and the existence of a code of conduct are necessary conditions for participation in the Wolfsberg Group, whereas factors related to the type of financial institution, combined with the existence of a black list, are sufficient for explaining participation.

Microfluidic processor allows rapid HER2 immunohistochemistry of breast carcinomas and significantly reduces ambiguous (2+) read-outs.

Biomarker analysis is playing an essential role in cancer diagnosis, prognosis, and prediction. Quantitative assessment of immunohistochemical biomarker expression on tumor tissues is of clinical relevance when deciding targeted treatments for cancer patients. Here, we report a microfluidic tissue processor that permits accurate quantification of the expression of biomarkers on tissue sections, enabled by the ultra-rapid and uniform fluidic exchange of the device. An important clinical biomarker for invasive breast cancer is human epidermal growth factor receptor 2 [(HER2), also known as neu], a transmembrane tyrosine kinase that connotes adverse prognostic information for the patients concerned and serves as a target for personalized treatment using the humanized antibody trastuzumab. Unfortunately, when using state-of-the-art methods, the intensity of an immunohistochemical signal is not proportional to the extent of biomarker expression, causing ambiguous outcomes. Using our device, we performed tests on 76 invasive breast carcinoma cases expressing various levels of HER2. We eliminated more than 90% of the ambiguous results (n = 27), correctly assigning cases to the amplification status as assessed by in situ hybridization controls, whereas the concordance for HER2-negative (n = 31) and -positive (n = 18) cases was 100%. Our results demonstrate the clinical potential of microfluidics for accurate biomarker expression analysis. We anticipate our technique will be a diagnostic tool that will provide better and more reliable data, onto which future treatment regimes can be based.

An image quality comparison of standard and dual-side read CR systems for pediatric radiology.

An objective analysis of image quality parameters was performed for a computed radiography (CR) system using both standard single-side and prototype dual-side read plates. The pre-sampled modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE) for the systems were determined at three different beam qualities representative of pediatric chest radiography, at an entrance detector air kerma of 5 microGy. The NPS and DQE measurements were realized under clinically relevant x-ray spectra for pediatric radiology, including x-ray scatter radiations. Compared to the standard single-side read system, the MTF for the dual-side read system is reduced, but this is offset by a significant decrease in image noise, resulting in a marked increase in DQE (+40%) in the low spatial frequency range. Thus, for the same image quality, the new technology permits the CR system to be used at a reduced dose level.

Prémisses indéniables, mais dialogue de sourds quand même : la liberté d'expression au prisme d'une votation helvétique (initiative "muselière")

Peut-on débattre sur cet arrière-plan topique universel que sont les Droits de l'Homme ? Si tout le monde est d'accord avec ces principes, est-il encore possible d'assister à d'irrémédiables coupures argumentatives entre deux camps pratiquant le dialogue de sourds (Angenot 2008) ? L'analyse d'un corpus tout à fait particulier qui représente toute une production textuelle servant aux citoyens suisses pour se forger une opinion avant un référendum tend à montrer que oui. Ce corpus journalistique et politique se fonde sur un cas assez aigu de débat autour de la liberté d'expression. Ces textes commentent un projet émanant de citoyens suisses qui visait à interdire à l'exécutif fédéral de se prononcer sur un sujet de vote pendant la campagne précédant la votation, le but étant de ne pas influencer par leur autorité le choix des citoyens. Restreindre ainsi la liberté d'expression au profit supposé d'une liberté de choix et de discernement conduit à une bataille entre deux camps. La rhétorique éristique qui en résulte confirme l'hypothèse du dialogue de sourds en se fondant sur une stigmatisation du camp adverse, un combat autour de définitions clés et un désaccord sur le relevé des problèmes. Moins que des arguments, les adversaires se renvoient des questions de frontières, de lexique et de légitimité.