1 resultado para Petroleum fuels.
em Université de Lausanne, Switzerland
Filtro por publicador
- Aberdeen University (5)
- Academic Archive On-line (Karlstad University; Sweden) (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (1)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (1)
- Applied Math and Science Education Repository - Washington - USA (1)
- Aquatic Commons (13)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (1)
- Archive of European Integration (54)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (3)
- Aston University Research Archive (36)
- Biblioteca Digital da Câmara dos Deputados (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (10)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (5)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (4)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (3)
- Bucknell University Digital Commons - Pensilvania - USA (3)
- CaltechTHESIS (4)
- Cambridge University Engineering Department Publications Database (30)
- CentAUR: Central Archive University of Reading - UK (3)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (33)
- Cochin University of Science & Technology (CUSAT), India (8)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (10)
- Deakin Research Online - Australia (24)
- Digital Commons - Michigan Tech (6)
- Digital Commons - Montana Tech (1)
- Digital Commons @ DU | University of Denver Research (3)
- Digital Commons at Florida International University (1)
- Digital Repository at Iowa State University (3)
- DigitalCommons@The Texas Medical Center (2)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (1)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (1)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (4)
- Helda - Digital Repository of University of Helsinki (18)
- Indian Institute of Science - Bangalore - Índia (115)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (6)
- Instituto Politécnico do Porto, Portugal (3)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (1)
- Laboratório Nacional de Energia e Geologia - Portugal (1)
- Massachusetts Institute of Technology (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (9)
- Publishing Network for Geoscientific & Environmental Data (19)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (12)
- Queensland University of Technology - ePrints Archive (205)
- Repositorio Academico Digital UANL (1)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (3)
- Repositório Institucional da Universidade de Aveiro - Portugal (4)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional da Universidade Federal do Rio Grande - FURG (2)
- Repositorio Institucional de la Universidad Nacional Agraria (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (52)
- Repositorio Institucional Universidad Católica de Colombia (1)
- Universidad de Alicante (6)
- Universidad Politécnica de Madrid (11)
- Universidade Federal do Rio Grande do Norte (UFRN) (11)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (1)
- Université de Montréal, Canada (2)
- University of Michigan (150)
- University of Queensland eSpace - Australia (7)
- University of Washington (2)
- WestminsterResearch - UK (5)
Resumo:
The Wnt pathway is abnormally activated in the majority of colorectal cancers, and significant knowledge has been gained in understanding its role in tumor initiation. However, the mechanisms of metastatic outgrowth in colorectal cancer remain a major challenge. We report that autophagy-dependent metabolic adaptation and survival of metastatic colorectal cancer cells is regulated by the target of oncogenic Wnt signaling, homeobox transcription factor PROX1, expressed by a subpopulation of colon cancer progenitor/stem cells. We identify direct PROX1 target genes and show that repression of a pro-apoptotic member of the BCL2 family, BCL2L15, is important for survival of PROX1(+) cells under metabolic stress. PROX1 inactivation after the establishment of metastases prevented further growth of lesions. Furthermore, autophagy inhibition efficiently targeted metastatic PROX1(+) cells, suggesting a potential therapeutic approach. These data identify PROX1 as a key regulator of the transcriptional network contributing to metastases outgrowth in colorectal cancer.