1 resultado para Ordinary Least Squares
em Université de Lausanne, Switzerland
Filtro por publicador
- Aberystwyth University Repository - Reino Unido (4)
- Academic Archive On-line (Mid Sweden University; Sweden) (1)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- Aquatic Commons (11)
- Archive of European Integration (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (8)
- Aston University Research Archive (12)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (17)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (5)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (5)
- Boston University Digital Common (7)
- Brock University, Canada (8)
- Bucknell University Digital Commons - Pensilvania - USA (2)
- Bulgarian Digital Mathematics Library at IMI-BAS (3)
- CaltechTHESIS (11)
- Cambridge University Engineering Department Publications Database (21)
- CentAUR: Central Archive University of Reading - UK (132)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (63)
- Cochin University of Science & Technology (CUSAT), India (4)
- Collection Of Biostatistics Research Archive (2)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (3)
- CORA - Cork Open Research Archive - University College Cork - Ireland (2)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (3)
- CUNY Academic Works (1)
- Deakin Research Online - Australia (82)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons - Michigan Tech (3)
- Digital Commons at Florida International University (1)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (7)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- Duke University (10)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (27)
- Helda - Digital Repository of University of Helsinki (9)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (93)
- Instituto Politécnico de Bragança (1)
- Instituto Politécnico do Porto, Portugal (4)
- Massachusetts Institute of Technology (4)
- Ministerio de Cultura, Spain (1)
- Nottingham eTheses (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- Publishing Network for Geoscientific & Environmental Data (4)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (61)
- Queensland University of Technology - ePrints Archive (141)
- Repositorio Academico Digital UANL (1)
- Repositório Científico da Universidade de Évora - Portugal (4)
- Repositório digital da Fundação Getúlio Vargas - FGV (32)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório Digital da Universidade Municipal de São Caetano do Sul - USCS (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (12)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (2)
- Repositorio Institucional de la Universidad Pública de Navarra - Espanha (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (31)
- Repositorio Institucional Universidad EAFIT - Medelin - Colombia (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (4)
- SAPIENTIA - Universidade do Algarve - Portugal (9)
- SerWisS - Server für Wissenschaftliche Schriften der Fachhochschule Hannover (1)
- Universidad del Rosario, Colombia (7)
- Universidad Politécnica de Madrid (10)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal de Uberlândia (1)
- Universidade Federal do Pará (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (15)
- Universidade Metodista de São Paulo (2)
- Universidade Técnica de Lisboa (1)
- Universitat de Girona, Spain (4)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (5)
- Université de Lausanne, Switzerland (1)
- Université de Montréal (2)
- Université de Montréal, Canada (18)
- Université Laval Mémoires et thèses électroniques (1)
- University of Connecticut - USA (1)
- University of Michigan (6)
- University of Queensland eSpace - Australia (4)
- University of Washington (1)
- WestminsterResearch - UK (1)
Resumo:
Although the relationship between serum uric acid (SUA) and adiposity is well established, the direction of the causality is still unclear in the presence of conflicting evidences. We used a bidirectional Mendelian randomization approach to explore the nature and direction of causality between SUA and adiposity in a population-based study of Caucasians aged 35 to 75 years. We used, as instrumental variables, rs6855911 within the SUA gene SLC2A9 in one direction, and combinations of SNPs within the adiposity genes FTO, MC4R and TMEM18 in the other direction. Adiposity markers included weight, body mass index, waist circumference and fat mass. We applied a two-stage least squares regression: a regression of SUA/adiposity markers on our instruments in the first stage and a regression of the response of interest on the fitted values from the first stage regression in the second stage. SUA explained by the SLC2A9 instrument was not associated to fat mass (regression coefficient [95% confidence interval]: 0.05 [-0.10, 0.19] for fat mass) contrasting with the ordinary least square estimate (0.37 [0.34, 0.40]). By contrast, fat mass explained by genetic variants of the FTO, MC4R and TMEM18 genes was positively and significantly associated to SUA (0.31 [0.01, 0.62]), similar to the ordinary least square estimate (0.27 [0.25, 0.29]). Results were similar for the other adiposity markers. Using a bidirectional Mendelian randomization approach in adult Caucasians, our findings suggest that elevated SUA is a consequence rather than a cause of adiposity.