Les premiers lecteurs de Walras en Russie (1890-1919)

Cet article offre la première chronologie des lecteurs de Walras en Russie, entre 1890 et 1919. Ce panorama de la pensée économique russe est le résultat de recherches originales effectuées dans des bibliothèques en Russie, ainsi que quelques fonds d'archives. La plupart de ces informations sont en soi inédites. Elles ne constituent toutefois que des matériaux pour de subséquentes recherches, qui sont esquissées dans le commentaire final de cet article.

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast.

Telomeric TG-rich repeats and their associated proteins protect the termini of eukaryotic chromosomes from end-to-end fusions. Associated with the cap structure at yeast telomeres is a subtelomeric domain of heterochromatin, containing the silent information regulator (SIR) complex. The Ku70/80 heterodimer (yKu) is associated both with the chromosome end and with subtelomeric chromatin. Surprisingly, both yKu and the chromatin-associated Rap1 and SIR proteins are released from telomeres in a RAD9-dependent response to DNA damage. yKu is recruited rapidly to double-strand cuts, while low levels of SIR proteins are detected near cleavage sites at later time points. Consistently, yKu- or SIR-deficient strains are hypersensitive to DNA-damaging agents. The release of yKu from telomeric chromatin may allow efficient scanning of the genome for DNA strand breaks.