1 resultado para Hoffman, Malvina,
em Université de Lausanne, Switzerland
Filtro por publicador
- Academic Archive On-line (Jönköping University; Sweden) (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (1)
- Applied Math and Science Education Repository - Washington - USA (4)
- Aquatic Commons (4)
- Archive of European Integration (23)
- Aston University Research Archive (10)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (6)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (10)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (3)
- Bibloteca do Senado Federal do Brasil (1)
- Biodiversity Heritage Library, United States (3)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (18)
- Boston College Law School, Boston College (BC), United States (1)
- Boston University Digital Common (1)
- Brock University, Canada (1)
- CaltechTHESIS (3)
- Cambridge University Engineering Department Publications Database (6)
- CentAUR: Central Archive University of Reading - UK (15)
- Center for Jewish History Digital Collections (4)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (47)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (3)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- CUNY Academic Works (1)
- Deakin Research Online - Australia (17)
- Digital Commons - Michigan Tech (2)
- Digital Commons - Montana Tech (3)
- Digital Commons at Florida International University (2)
- Digital Repository at Iowa State University (7)
- DigitalCommons@The Texas Medical Center (5)
- DigitalCommons@University of Nebraska - Lincoln (3)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (10)
- DRUM (Digital Repository at the University of Maryland) (3)
- Duke University (6)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (1)
- Harvard University (3)
- Helda - Digital Repository of University of Helsinki (2)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (2)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (3)
- Instituto Politécnico do Porto, Portugal (3)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (11)
- Memoria Académica - FaHCE, UNLP - Argentina (3)
- Memorial University Research Repository (1)
- Ministerio de Cultura, Spain (5)
- National Center for Biotechnology Information - NCBI (18)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Portal de Revistas Científicas Complutenses - Espanha (8)
- Publishing Network for Geoscientific & Environmental Data (3)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (13)
- Queensland University of Technology - ePrints Archive (25)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (3)
- Repositório Digital da Universidade Municipal de São Caetano do Sul - USCS (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositorio Institucional de la Universidad de Málaga (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (6)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (1)
- School of Medicine, Washington University, United States (1)
- Universidad Autónoma de Nuevo León, Mexico (1)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (53)
- Universidad Politécnica de Madrid (1)
- Universidade Federal do Pará (2)
- Universidade Metodista de São Paulo (2)
- Université de Lausanne, Switzerland (1)
- Université de Montréal, Canada (2)
- University of Michigan (108)
- University of Queensland eSpace - Australia (14)
- University of Washington (3)
Resumo:
Oligodendroglia support axon survival and function through mechanisms independent of myelination, and their dysfunction leads to axon degeneration in several diseases. The cause of this degeneration has not been determined, but lack of energy metabolites such as glucose or lactate has been proposed. Lactate is transported exclusively by monocarboxylate transporters, and changes to these transporters alter lactate production and use. Here we show that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models. In addition, this same transporter is reduced in patients with, and in mouse models of, amyotrophic lateral sclerosis, suggesting a role for oligodendroglial MCT1 in pathogenesis. The role of oligodendroglia in axon function and neuron survival has been elusive; this study defines a new fundamental mechanism by which oligodendroglia support neurons and axons.