Statistique des coûts et des prestations

On connaît le manque de données permettant de s'assurer que les prestations prises en charge par la LAMal sont adéquates, efficaces et économiques. L'Office fédéral de la santé publique (OFSP) a décidé de proposer et faire valider quelques nouveaux indicateurs. Le but du présent article est de présenter les projets qui vont être mis en oeuvre entre l'été 2008 et 2011. [Intertitres] Identification des maladies. Episodes ambulatoires. Mesure de l'impact des soins sur l'état de santé. Prévention. Etablissement de profils de pratique médicaux. Hospitalisations potentiellement évitables. Calendrier et coût des projets.

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P < 5 × 10(-8) in combined discovery and follow-up analyses of 52 studies comprising up to 96,496 non-diabetic individuals. Risk variants were associated with higher triglyceride and lower high-density lipoprotein (HDL) cholesterol levels, suggesting a role for these loci in insulin resistance pathways. The discovery of these loci will aid further characterization of the role of insulin resistance in T2D pathophysiology.