16 resultados para Lipid - Metabolism -Disorders
Filtro por publicador
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (6)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (2)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (4)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (3)
- Aston University Research Archive (19)
- Biblioteca de Teses e Dissertações da USP (3)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (44)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (16)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (10)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (67)
- Brock University, Canada (2)
- Cambridge University Engineering Department Publications Database (1)
- CentAUR: Central Archive University of Reading - UK (51)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (9)
- Cochin University of Science & Technology (CUSAT), India (3)
- CORA - Cork Open Research Archive - University College Cork - Ireland (3)
- Deakin Research Online - Australia (87)
- DigitalCommons@The Texas Medical Center (16)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- DRUM (Digital Repository at the University of Maryland) (3)
- Duke University (5)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (2)
- FUNDAJ - Fundação Joaquim Nabuco (2)
- Helda - Digital Repository of University of Helsinki (45)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (28)
- Instituto Nacional de Saúde de Portugal (1)
- Instituto Politécnico de Viseu (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (1)
- National Center for Biotechnology Information - NCBI (21)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (3)
- Publishing Network for Geoscientific & Environmental Data (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (28)
- Queensland University of Technology - ePrints Archive (218)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (1)
- Repositório Científico da Universidade de Évora - Portugal (2)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (5)
- Repositório Institucional da Universidade de Brasília (2)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (109)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- Scielo España (2)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (5)
- Universidad Politécnica de Madrid (1)
- Universidade Complutense de Madrid (1)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (2)
- Universidade Federal do Pará (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (2)
- Universidade Técnica de Lisboa (1)
- Universita di Parma (1)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (16)
- Université de Montréal (2)
- Université de Montréal, Canada (33)
- Université Laval Mémoires et thèses électroniques (2)
- University of Queensland eSpace - Australia (26)
- WestminsterResearch - UK (2)
- Worcester Research and Publications - Worcester Research and Publications - UK (2)
Resumo:
Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with genetically engineered lines of mice optimized to study single gene function. Here, we systematically acquired metabolic phenotypes by using the EUMODIC EMPReSS protocols across a large panel of isogenic but diverse strains of mice (BXD type) to study the genetic control of metabolism. We generated and analyzed 140 classical phenotypes and deposited these in an open-access web service for systems genetics (www.genenetwork.org). Heritability, influence of sex, and genetic modifiers of traits were examined singly and jointly by using quantitative-trait locus (QTL) and expression QTL-mapping methods. Traits and networks were linked to loci encompassing both known variants and novel candidate genes, including alkaline phosphatase (ALPL), here linked to hypophosphatasia. The assembled and curated phenotypes provide key resources and exemplars that can be used to dissect complex metabolic traits and disorders.