19 resultados para Virolainen, Jyrki: Pro
em Consorci de Serveis Universitaris de Catalunya (CSUC), Spain
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Lobjectiu de la recerca que sha dut a terme durant el perode 2004-2007 ha estat analitzar les caracterstiques territorials, senyorials i jurisdiccionals del domini format pel comtat de les Muntanyes de Prades i la baronia dEntena i, a partir daqu, aprofundir en un aspecte concret daquesta senyoria: lexplotaci minera de largent durant els segles XIV i XV. En aquest sentit, la recerca sha fonamentat en lestudi de la documentaci relacionada amb aquesta qesti que hi ha dipositada a lArxiu Ducal de Medinaceli; la qual, per, sha pogut buidar i analitzar a travs de la consulta de les cpies microfilmades que sen conserven al Monestir de Poblet. Com a resultats principals sha aconseguit delimitar territorialment el comtat de les Muntanyes de Prades i baronia dEntena i determinar-ne la titularitat jurisdiccional a mitjan segle XIV. A ms, shan establert els parmetres que marquen i expliquen levoluci de la normativa que regulava lexplotaci minera de largent. I, finalment, sha pogut determinar que, segurament, la major part de largent produt a mitjan segle XIV es va obtenir a partir de minerals dargent i argent natiu.
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El projecte consisteix en el desenvolupament d'una comanda amb GeoMedia Professional 6.1 que permeti la representaci temtica de dades i ubicar-les sobre el mapa.
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L'objectiu s realitzar una explicaci dels passos i les tasques realitzades per a la construcci d'un Sistema d'Informaci Geogrfica (SIG) que permeti la gesti de vrtex geodsics de Catalunya i la implementaci de l'algorisme de Delaunay sobre un conjunt de vrtex seleccionats.
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Treball consistent en la construcci d'un exportador a format KML de mapes temtics pel producte Geomedia PRO 6.1 possibilitant l'observaci del component del temps sobre un globus virtual com s Google Earth. Mitjanant les dades de la xarxa XEMEC, es mostrar un mapa temtic d'exemple amb les dades d'intensitat i direcci del vent recollides en un perode d'un any.
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Concretament, l'objectiu principal d'aquest projecte s el de construir un sistema de Informaci Geogrfic que permeti l'anlisi de les diferents rutes i camins existents entre Tarraco (Tarragona) i St Bertrand de Comminges (Frana) passant per Ilerda (Lleida) amb l'objectiu de trobar el cam de mnim cost travessant els Pirineus.
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Este trabajo recoge la experiencia llevada a cabo en tres asignaturas en cuanto a la aplicacin de recomendaciones (acciones) dirigidas a la mejora de la alineacin entre las competencias planteadas en los respectivos planes docentes, la metodologa para trabajarlas y evaluacin de las mismas. Concretamente las asignaturas que han puesto en marcha estas recomendaciones pertenecen a la Universidad Pompeu Fabra (una asignatura) y a la Universidad de Valladolid (las otras dos) todas pertenecientes al rea de Ingeniera Telemtica. Adems de incluir una breve descripcin de las recomendaciones aplicadas se presenta el contexto de cada caso (caractersticas bsicas de las asignaturas), el proceso seguido durante su aplicacin as como la evaluacin llevada a cabo (tanto durante el proceso de aplicacincomo al finalizar) para conocer el nivel de satisfaccin tanto del colectivo discente como del docente. Finalmente se incluyen las reflexiones realizadas en forma de conclusiones que giran entorno a dos ejes: el primero de ellos es el impacto de la aplicacin de las recomendaciones en la calidad de la funcin docente y el segundo hace referencia al aumento de la visibilidad de esta relacin desde la perspectiva discente y las repercusiones en su proceso de aprendizaje.
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We argue that in the development of the Western legal system, cognitive departures are themain determinant of the optimal degree of judicial rule-making. Judicial discretion, seen here as the main distinguishing feature between both legal systems, is introduced in civil law jurisdictions to protect, rather than to limit, freedom of contract against potential judicial backlash. Such protection was unnecessary in common law countries, where free-market relations enjoyed safer judicial ground mainly due to their relatively gradual evolution, their reliance on practitioners as judges, and the earlier development of institutional checks and balances that supported private property rights. In our framework, differences in costs and benefits associated with self-interest and lack of information require a cognitive failure to be active.
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Podeu consultar la versi en castell a http://hdl.handle.net/2445/8965
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Podeu consultar la versi en catal a http://hdl.handle.net/2445/8964
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Background. Microglia and astrocytes respond to homeostatic disturbances with profound changes of gene expression. This response, known as glial activation or neuroinflammation, can be detrimental to the surrounding tissue. The transcription factor CCAAT/enhancer binding protein (C/EBP) is an important regulator of gene expression in inflammation but little is known about its involvement in glial activation. To explore the functional role of C/EBP in glial activation we have analyzed pro-inflammatory gene expression and neurotoxicity in murine wild type and C/EBP-null glial cultures. Methods. Due to fertility and mortality problems associated with the C/EBP-null genotype we developed a protocol to prepare mixed glial cultures from cerebral cortex of a single mouse embryo with high yield. Wild-type and C/EBP-null glial cultures were compared in terms of total cell density by Hoechst-33258 staining; microglial content by CD11b immunocytochemistry; astroglial content by GFAP western blot; gene expression by quantitative real-time PCR, western blot, immunocytochemistry and Griess reaction; and microglial neurotoxicity by estimating MAP2 content in neuronal/microglial cocultures. C/EBP DNA binding activity was evaluated by electrophoretic mobility shift assay and quantitative chromatin immunoprecipitation. Results. C/EBP mRNA and protein levels, as well as DNA binding, were increased in glial cultures by treatment with lipopolysaccharide (LPS) or LPS + interferon (IFN). Quantitative chromatin immunoprecipitation showed binding of C/EBP to pro-inflammatory gene promoters in glial activation in a stimulus- and gene-dependent manner. In agreement with these results, LPS and LPS+IFN induced different transcriptional patterns between pro-inflammatory cytokines and NO synthase-2 genes. Furthermore, the expressions of IL-1 and NO synthase-2, and consequent NO production, were reduced in the absence of C/EBP. In addition, neurotoxicity elicited by LPS+IFN-treated microglia co-cultured with neurons was completely abolished by the absence of C/EBP in microglia.
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BackgroundIn adult population with community acquired pneumonia high levels of pro-adrenomedullin (pro-ADM) have been shown to be predictors of worse prognosis. The role of this biomarker in pediatric patients had not been analyzed to date. The objective of this study is to know the levels of pro-ADM in children with community acquired pneumonia (CAP) and analyze the relation between these levels and the patients prognosis.FindingsProspective observational study including patients attended in the emergency service (January to October 2009) admitted to hospital with CAP and no complications at admission. The values for pro-ADM were analyzed in relation to: need for oxygen therapy, duration of oxygen therapy, fever and antibiotic therapy, complications, admission to the intensive care unit, and length of hospital stay. Fifty patients were included. Ten presented complications (7 pleural effusion). The median level of pro-ADM was 1.0065nmol/L (range 0.3715 to 7.2840nmol/L). The patients presenting complications had higher levels of pro-ADM (2.3190 vs. 1.1758nmol/L, p=0.013). Specifically, the presence of pleural effusion was associated with higher levels of pro-ADM (2.9440 vs. 1.1373nmol/L, p<0.001).ConclusionsIn our sample of patients admitted to hospital with CAP, pro-ADM levels are related to the development of complications during hospitalization.
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Sensor networks have many applications in monitoring and controlling of environmental properties such as sound, acceleration, vibration and temperature. Due to limitedresources in computation capability, memory and energy, they are vulnerable to many kinds of attacks. The ZigBee specification based on the 802.15.4 standard, defines a set of layers specifically suited to sensor networks. These layers support secure messaging using symmetric cryptographic. This paper presents two different ways for grabbing the cryptographic key in ZigBee: remote attack and physical attack. It also surveys and categorizes some additional attacks which can be performed on ZigBee networks: eavesdropping, spoofing, replay and DoS attacks at different layers. From this analysis, it is shown that some vulnerabilities still in the existing security schema in ZigBee technology.
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Aplicaci de clcul nutricional que permet les segents funcionalitats: Gesti dIndividus/Pacients permet organitzar els pacients en carpetes i subcarpetes, podent incorporar un histric de dades antropomtriques i diettic i calcular els segents dades: IMC (ndex de Massa Corporal), ndex Cintura / Maluc, Estima el pes ideal orientatiu, Estimaci de Despesa Energtica per: Harris-Benedict, FAO-OMS, Mifflin-St. Jeor. En base a la informaci introduda a la pestanya Activitat Fsica estima tamb la despesa energtica tenint en compte lactivitat fsica realitzada per lindividu (permet estimar la despesa energtica per 605 activitats).Estimaci de necessitats energtiques en malalts per Long et al. i Ireton-Jones amb la base del clcul del Metabolisme Basal de Harris-Benedict. Introduint els plecs (Plec Pectoral, Plec Bceps, Plec Abdominal, Plec Supraespinal, Plec Cuixa anterior, Plec Cama medial, Plec Subescapular, Plec Tricipital), els dimetres (Dimetre Antero-Posterior Trax, Dimetre Sagital, Dimetre Hmer, Dimetre Fmur, Dimetre Biacromial, Dimetre Transversal Trax, Dimetre Biileocrestal) i els permetres (Permetre Bra flexionat, Permetre Bra, Permetre Canell, Permetre Cuixa, Permetre Cama, Permetre Trax) el programa s capa de calcular el % de greix, massa ssia, massa muscular i massa residual per diferents frmules (% Gas Yuhasz, % Gras Faulkner, % Gras Siri, % Gras Brozek, Distribuci corporal de Drinkwater). Tamb calcula el permetre muscular del bra i la cama. Tamb calcula el Pes Objectiu en relaci a un % Greix objectiu, calculant quin pes hauria de tenir el pacient per un % de Greix donat.
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Background: Toll-like receptors (TLRs) are critical components for host pathogen recognition and variants in genes participating in this response influence susceptibility to infections. Recently, TLR1 gene polymorphisms have been found correlated with whole blood hyper-inflammatory responses to pathogen-associated molecules and associated with sepsis-associated multiorgan dysfunction and acute lung injury (ALI). We examined the association of common variants of TLR1 gene with sepsis-derived complications in an independent study and with serum levels for four inflammatory biomarker among septic patients. Methodology/Principal Findings: Seven tagging single nucleotide polymorphisms of the TLR1 gene were genotyped in samples from a prospective multicenter case-only study of patients with severe sepsis admitted into a network of intensive care units followed for disease severity. Interleukin (IL)-1 b, IL-6, IL-10, and C-reactive protein (CRP) serum levels were measured at study entry, at 48 h and at 7th day. Alleles -7202G and 248Ser, and the 248Ser-602Ile haplotype were associated with circulatory dysfunction among severe septic patients (0.001<=p <= 0.022), and with reduced IL-10 (0.012<= p <=0.047) and elevated CRP (0.011<= p <=0.036) serum levels during the first week of sepsis development. Additionally, the -7202GG genotype was found to be associated with hospital mortality (p =0.017) and ALI (p =0.050) in a combined analysis with European Americans, suggesting common risk effects among studies Conclusions/Significance: These results partially replicate and extend previous findings, supporting that variants of TLR1 gene are determinants of severe complications during sepsis.
