Sistema de informaci��n SIGARQ: desarrollo de un aplicativo S.I.G. para la gesti��n de la secuencia estratigr��fica de una intervenci��n arqueol��gica

El Sistema de Informaci��n Geogr��fica Arqueol��gico (SIGARQ), pretende ser una herramienta que permita integrar, gestionar y analizar todos aquellos datos procedentes de cualquier tipo de intervenci��n arqueol��gica independientemente de la naturaleza del elemento patrimonial a estudiar y de la t��cnica de trabajo empleada en la intervenci��n. Al mismo tiempo ha de permitir contextualizar cada una de las intervenciones y sus resultados en un marco geogr��fico m��s extenso. De esta manera, el proyecto actual tambi��n supone un avance de las potencialidades del sistema de cara a la gesti��n patrimonial del territorio y los estudios de car��cter paisaj��stico.

Selecci��n de p��ptidos sint��ticos del Virus de la Hepatitis G (GBV-C/HGV) inhibidores del P��ptido de Fusi��n HIV-I

El GB virus C (GBV-C) o virus de l'hepatitis G (HGV) es un virus format per una ��nica cadena de RNA que pertany a la familia Flaviviridae. En els ��ltims anys, s'han publicat nombrosos treballs en els quals s'associa la coinfecci�� del GBV-C i del virus de la immunodefici��ncia humana (VIH) amb una menor progressi�� de l'esmentada malaltia aix�� com amb una major superviv��ncia dels pacients una vegada que la SIDA s'ha desenvolupat. El mecanisme pel qual el virus GBV-C/HGV exerceix un ���efecte protector��� en els pacients amb VIH encara no est�� descrit. L���estudi de la interacci�� entre els virus GBVC/HGV i VIH podria donar lloc al desenvolupament de nous agents terap��utics per al tractament de la SIDA.Treballs recents mostren com la capacitat inhibit��ria del virus del GBV-C/HGV ��s deguda a la seva glicoproteina estructural E2. S���ha vist que aquesta proteina seria capa�� d���inhibir la primera fase de replicaci�� de VIH, aix�� com la uni�� i la fusi�� amb les membranes cel���lulars. Sobre la base d���aquests estudis, l���objectiu d���aquest treball ha estat seleccionar inhibidors del p��ptid de fusi�� del VIH utilitzant p��ptids sint��tics de la proteina E2 del GBV-C/HGV. El treball realitzat ha consistit en estudiar, utilitzant assajos biof��sics de leakage i de lipid mixing, la capacitat dels p��ptids de la proteina estructural del virus del GBV-C/HGV per inhibir la interacci�� i el proc��s de desestabilitzaci�� de membranes indu��des pel p��ptid de fusi�� de la glicoproteina de l���embolcall, GP41, del VIH. Aquests assajos, com es descriu en treballs anteriors, han resultat ��tils per a la selecci�� i la identificaci�� de compostos amb activitat espec��fica anti-GP41. Es pot afirmar que efectivament els p��ptids seleccionats de la proteina E2 del virus del GBV-C/HGV inhibeixen l���activitat del p��ptid de fusi�� del VIH probablement com a consequ��ncia d���un canvi conformacional en aquest darrer.

Dise��o de la herramienta G.I.A. (Gesti��n Integral de Accesibilidad)

Con este PFC se ha pretendido desarrollar una herramienta que permita a organismos encargados de la gesti��n de la accesibilidad la realizaci��n de Planes Integrales de Accesibilidad de forma ��gil e intuitiva, consiguiendo con ello mejorar la accesibilidad global dentro de un municipio y por consiguiente a los ciudadanos en general. De esta manera se dispondr�� de informaci��n actualizada que reduzca las barreras arquitect��nicas y mejore la accesibilidad universal de los espacios p��blicos.

Adaptive intelligent agent approach to guide the web navigation on the PLAN-G distance learning platform

Hypermedia systems based on the Web for open distance education are becoming increasinglypopular as tools for user-driven access learning information. Adaptive hypermedia is a new direction in research within the area of user-adaptive systems, to increase its functionality by making it personalized [Eklu 961. This paper sketches a general agents architecture to include navigationaladaptability and user-friendly processes which would guide and accompany the student during hislher learning on the PLAN-G hypermedia system (New Generation Telematics Platform to Support Open and Distance Learning), with the aid of computer networks and specifically WWW technology [Marz 98-1] [Marz 98-2]. The PLAN-G actual prototype is successfully used with some informatics courses (the current version has no agents yet). The propased multi-agent system, contains two different types of adaptive autonomous software agents: Personal Digital Agents {Interface), to interacl directly with the student when necessary; and Information Agents (Intermediaries), to filtrate and discover information to learn and to adapt navigation space to a specific student

Vari��t��s CR polaris��es et G-polaris��es, partie I

Polarized and G-polarized CR manifolds are smooth manifolds endowed with a double structure: a real foliation &em&F&/em& (given by the action of a Lie group G in the G-polarized case) and a transverse CR distribution. Polarized means that (E,J) is roughly speaking invariant by&em&F&/em&. Both structures are therefore linked up. The interplay between them gives to polarized CR-manifolds a very rich geometry. In this paper, we study the properties of polarized and G-polarized manifolds, putting special emphasis on their deformations.

Conformations of poly{G}-poly{C} �� stacks with high hole mobility

Charge transfer properties of DNA depend strongly on the �� stack conformation. In the present paper, we identify conformations of homogeneous poly-{G}-poly-{C} stacks that should exhibit high charge mobility. Two different computational approaches were applied. First, we calculated the electronic coupling squared, V2, between adjacent base pairs for all 1 ps snapshots extracted from 15 ns molecular dynamics trajectory of the duplex G15. The average value of the coupling squared ��� V2 ��� is found to be 0.0065 eV2. Then we analyze the base-pair and step parameters of the configurations in which V2 is at least an order of magnitude larger than ��� V2 ���. To obtain more consistent data, ���65 000 configurations of the (G:C)2 stack were built using systematic screening of the step parameters shift, slide, and twist. We show that undertwisted structures (twist<20��) are of special interest, because the �� stack conformations with strong electronic couplings are found for a wide range of slide and shift. Although effective hole transfer can also occur in configurations with twist=30�� and 35��, large mutual displacements of neighboring base pairs are required for that. Overtwisted conformation (twist38��) seems to be of limited interest in the context of effective hole transfer. The results may be helpful in the search for DNA based elements for nanoelectronics

G. La dif��cil construcci�� d'Europa (des de Ni��a i Lisboa, darrere d'una Constituci��)

Cont��: La anemia de Europa; La Europa de Niza; Las grandes v��speras de Europa; La cara oscura de Europa; El doble salto de la Uni��n Europea; La UE, ante una empinada cuesta; La Constituaci��n deseada y temida; La Europa constitucional, aplazada; Europa, esperanza y desencanto; Turqu��a, dilema europeo; ��Turqu��a es Europa?; ��C��mo hay que ser europeo?; El voto del rechazo; La Uni��n Europea, bloqueada; La UE que llega al mar Negro; La Europa de Angela Merkel; El mundo en que naci�� la CEE; Turqu��a, en el lindar europeo; Que el tiempo decida���; La UE, entre dos extremos; La UE, cuesti��n de supervivencia

Similarities and convergence in G-7 cycles

This paper examines the properties of G-7 cycles using a multicountry Bayesian panelVAR model with time variations, unit specific dynamics and cross country interdependences.We demonstrate the presence of a significant world cycle and show that country specificindicators play a much smaller role. We detect differences across business cycle phasesbut, apart from an increase in synchronicity in the late 1990s, find little evidence of major structural changes. We also find no evidence of the existence of an Euro area specific cycle or of its emergence in the 1990s.

On the sources of business cycles in the G-7

This paper examines sources of cyclical movements in output, inflation and the term structure of interest rates. It employs a novel identification approach which uses the sign of the cross correlation function in response to shocks to catalog orthogonal disturbances. We find that demand shocks are the dominant source output, inflation and term structure fluctuations in six of the G-7 countries. Within the class of demand disturbances, nominal shocks are dominant, but their importance declined after 1982. Furthermore, there are no significant differences in the proportion of term structure variability explained by different structural sources at different horizons.

UBVRI photometry of G, K, M Hipparcos stars

UBVRI data are presented for a set of 229 late-type stars, most of them being high proper motion stars. All these data are part of the Input Catalog planned observations for the Hipparcos mission.

UBVRI photometry of G, K, M Hipparcos stars. II.

As indicated by Grenon (1989), the data of the present series of reports on the UBVRI photometry of late-type stars in the Hipparcos Input Catalog are to be employed in computations of Hipparcos observing time, as well as in evaluating the observability of faint stars by the satellite. Attention is here given to late type stars in the V = 8-12 range, including distant red giants in the Galactic plane (Hipparcos proposal 189), as well as high proper motion stars included in the G, LTT, LP, and MCC catalogs.

El olvido de los derechos del hombre (G. Agamben, R. Esposito)

La paradoja m��s lacerante de nuestros d��as es la creciente distancia entre la Declaraci��n de los Derechos del Hombre de 1948 y su escasa implantaci��n en la realidad cotidiana. Los derechos del hombre s��lo son posibles teniendo como horizonte la Humanidad, no los Estados-naci��n. Los ap��tridas, los refugiados, los inmigrantes son el esc��ndalo y la denuncia de esa distancia entre "derechos del hombre" y "derechos del ciudadano". Cualquier raz��n -cultural, pol��tica, econ��mica- nos sirve para demonizar al "otro", al que no es como nosotros.

La ontolog��a del esp��ritu: principio de epistemolog��a de G. de Ockham

El principio radical de toda la filosof��a de Ockham no es ni una metaf��sica del singular, ni una actitud logicista, teologal oesc��ptica. El Inceptor es la culminaci��n de una tendencia neoplat��nica, tambi��n central en el Eri��gena: aun para la creatura humanalo "inteligente" es anterior y ontol��gicamente superior a lo "inteligible" o "sensible".Heredado de Agust��n de Hipona, pero transformado en el an��lisis hasta ser inmediato precedente de la Modernidad o comienzo de ella, el "yo pienso" es el quicio del sistema de Ockman. De la exacta acotaci��n moderna de "esp��ritu" arranca todo el sistema; a partir de ��l se justifican incluso los rasgos que m��s sorprende hallar en un fil��sofo del siglo XIV: la centralidad de las nociones opuestas "intuici��n/evidencia", la plena actividad cognoscitiva del esp��ritu junto a la pasividad del intelecto, la nula causalidad pr��xima de las cosas sensibles en el conocimiento humano, e! paradigma perfectamente ling����stico del conocer. El nacimiento de una moderna "teor��a del conocimiento", se da a partir de la constataci��n de que el acto m��s perfecto y paradigm��ticode la vida del esp��ritu es la intuici��n de los "intellectualia" que radican en ��l mismo, y no la captaci��n de los externos "sensibilia" aristot��licos.

Hepatitis G virus infection in primary Sj��gren's syndrome: analysis in a series of 100 patients.

OBJECTIVE To determine the prevalence and clinical significance of hepatitis G virus (HGV) infection in a large cohort of patients with primary Sj��gren��s syndrome (SS). PATIENTS AND METHODS The study included 100 consecutive patients (92 female and eight male), with a mean age of 62 years (range 31��80) that were prospectively visited in our unit. All patients fulfilled the European Community criteria for SS and underwent a complete history, physical examination, as well as biochemical and immunological evaluation for liver disease. Two hundred volunteer blood donors were also studied. The presence of HGV-RNA was investigated in the serum of all patients and donors. Aditionally, HBsAg and antibodies to hepatitis C virus were determined. RESULTS Four patients (4%) and six volunteer blood donors (3%) presented HGV-RNA sequences in serum. HGV infection was associated with biochemical signs of liver involvement in two (50%) patients. When compared with primary SS patients without HGV infection, no significant differences were found in terms of clinical or immunological features. HCV coinfection occurs in one (25%) of the four patients with HGV infection. CONCLUSION The prevalence of HGV infection in patients with primary SS is low in the geographical area of the study and HCV coinfection is very uncommon. HGV infection alone does not seen to be an important cause of chronic liver injury in the patients with primary SS in this area.