10 resultados para Nichols, Harold
em Consorci de Serveis Universitaris de Catalunya (CSUC), Spain
Resumo:
Aquest treball analitza l’impacte que ha tingut el dramaturg Harold Pinter a la ciutat de Barcelona des de la primer vegada que s’hi va representar, l’any 1963, fins que es va celebrar el festival Tardor Pinter, l’any 1996. La investigació s’ha fet, sobretot, a partir de la premsa de l’època però també s’ha tingut en compte material gràfic i entrevistes. L’objectiu ha estat observar l’evolució de l’opinió que suscitaven les obres d’aquest autor i com, de mica en mica es va arribar a convertir en un model creatiu per al grup d’El Teatro Fronterizo, encapçalat per José Sanchis Sinisterra.
Resumo:
This short paper addresses the problem of designing a QFT (quantitative feedback theory) based controllers for the vibration reduction in a 6-story building structure equipped with shear-mode magnetorheological dampers. A new methodology is proposed for characterizing the nonlinear hysteretic behavior of the MR damper through the uncertainty template in the Nichols chart. The design procedure for QFT control design is briefly presented
Resumo:
Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is associated with many human diseases including cancer. Extensive high-resolution structures (.100) and recent mutagenesis studies have laid the foundation for the design of new structure-based chemotherapeutic strategies. Although the inhibition of Rho signaling with drug-like compounds is an active area of current research, very little attention has been devoted to directly inhibiting Rho by targeting potential allosteric non-nucleotide binding sites. By avoiding the nucleotide binding site, compounds may minimize the potential for undesirable off-target interactions with other ubiquitous GTP and ATP binding proteins. Here we describe the application of molecular dynamics simulations, principal component analysis, sequence conservation analysis, and ensemble small-molecule fragment mapping to provide an extensive mapping of potential small-molecule binding pockets on Rho family members. Characterized sites include novel pockets in the vicinity of the conformationaly responsive switch regions as well as distal sites that appear to be related to the conformations of the nucleotide binding region. Furthermore the use of accelerated molecular dynamics simulation, an advanced sampling method that extends the accessible time-scale of conventional simulations, is found to enhance the characterization of novel binding sites when conformational changes are important for the protein mechanism.
Resumo:
This paper describes a failure alert system and a methodology for content reuse in a new instructional design system called InterMediActor (IMA). IMA provides an environment for instructional content design, production and reuse, and for students’ evaluation based in content specification through a hierarchical structure of competences. The student assessment process and information extraction process for content reuse are explained.
Resumo:
Se propone, al amparo del proyecto “Nuevos Algoritmos para la Gestión Eficiente de Contenidos Multimediaen Redes de Comunicaciones Móviles” (NAGEC), un nuevo mecanismo para la búsqueda y recuperación deimágenes basado en realimentación de relevancia. La arquitectura propuesta se compone de una red neuronal yun tesauro. La red neuronal extrae de las imágenes dos parámetros: textura y color. El tesauro recoge lasrelaciones semánticas existentes entre los términos descriptores de las imágenes de la base de datos VisTex.Ambos componentes se relacionan mediante un modelo de realimentación de relevancia que, a través de lasinteracciones del usuario con el tesauro durante el proceso de búsqueda, permite a la red aprender relacionessemánticas inherentes a las imágenes.
Resumo:
Computer based training or distance education are facing dramatic changes withthe advent of standardization efforts, some of them concentrating in maximal reuse.This is of paramount importance for a sustainable -cost affordable- production ofeducational materials. Reuse in itself should not be a goal, though, since manymethodological aspects might be lost. In this paper we propose two contentproduction approaches for the InterMediActor platform under a competence-basedmethodology: either a bottom-up approach where content is designed from scratchor a top-down methodology where existing material can be gradually adapted tofulfil requisites to be used with maximal flexibility into InterMediActor.
Resumo:
The Goliath grouper, Epinephelus itajara, a large-bodied (similar to 2.5 m TL, > 400 kg) and critically endangered fish (Epinephelidae), is highly Vulnerable to overfishing. Although protected from fishing in many countries, its exploitation in Mexico is unregulated; a situation that puts its populations at risk. Fishery records of E. itajara are scarce, which prevents determination of its fishery status. This work aimed to elucidate the E itajara fishery in the northern Yucatan Peninsula by 1) analyzing available catch records and 2) interviewing veteran fishermen (local ecological knowledge) from two traditional landing sites: Dzilam de Bravo and Puerto Progreso. Historic fishery records from two fishing cooperatives were analyzed in order to elucidate the current situation and offer viable alternatives for conservation and management. Catches have decreased severely. Local knowledge obtained from fishermen represented a very important source of information for reconstructing the fisheries history of this species. Conservation measures that incorporate regional and international regulations on critically endangered fish species are suggested
Resumo:
In this study, the population structure of the white grunt (Haemulon plumieri) from the northern coast of the Yucatan Peninsula was determined through an otolith shape analysis based on the samples collected in three locations: Celestún (N 20°49",W 90°25"), Dzilam (N 21°23", W 88°54") and Cancún (N 21°21",W 86°52"). The otolith outline was based on the elliptic Fourier descriptors, which indicated that the H. plumieri population in the northern coast of the Yucatan Peninsula is composed of three geographically delimited units (Celestún, Dzilam, and Cancún). Significant differences were observed in mean otolith shapes among all samples (PERMANOVA; F2, 99 = 11.20, P = 0.0002), and the subsequent pairwise comparisons showed that all samples were significantly differently from each other. Samples do not belong to a unique white grunt population, and results suggest that they might represent a structured population along the northern coast of the Yucatan Peninsula
Resumo:
La filòloga i novel·lista Helena Valentí i Petit (Barcelona, 1940-1990) s’exilià de ben jove a Anglaterra, on buscà en la traducció el mitjà de vida. Entre altres autors i autores, traslladà al castellà William Blake, Marilyn French, Nicholas Guild, Najib Mahfuz, Harold Robbins, Bernice Rubens, Roger T. Taylor i Doris Lessing, de la qual traduí El quadern daurat. De retorn a Catalunya, el 1974, decidí compaginar la traducció amb la narrativa pròpia. Girà a la llengua catalana Al far i Una cambra pròpia de l’anglesa Virginia Woolf i La garden party i altres contes i Un home casat i altres crueltats de la neozelandesa Katherine Mansfield. En els anys vuitanta traslladà El factor humà de Graham Greene i Jo, Claudi de Robert Graves, i féu una breu incursió en la narrativa per a joves. Viatges indiscrets de Lisa St. Aubin, un recull de contes d’autores del segle XX, fou l’última traducció.
Resumo:
Descripción de la realidad que acompaña a la industria de las telecomunicaciones