La ceguera como motivo en Ensayo sobre la ceguera de José Saramago e Informe sobre ciegos de Ernesto Sábato

El trabajo de investigación, El motivo de la ceguera en el Ensayo sobre la ceguera de José Saramago e Informe sobre ciegos de Ernesto Sábato, analiza desde el área y la metodología de la literatura comparada el uso del motivo literario de la ceguera en los dos textos mencionados, resaltando las similitudes y diferencias del tratamiento del motivo dentro de las dos obras y como éste sostiene una serie de obsesiones e ideas sobre el estado actual del mundo que comparten los autores de las dos novelas.

La caverna de José Saramago: imatge platònica versus metafísica

La caverna de José Saramago té com a referència indubtable la imatge de la caverna del llibre VII de la República de Plató, i, tanmateix, Saramago no és un escriptor idealista o metafísic. Aquest article mostra com, tot aprofitant l¿aplicabilitat amb què Plató dota la seva imatge, Saramago defensa la necessitat de saber rebre els missatges de la terra, de la matèria, de no esdevenir presoners en las cavernes daurades de la societat occidental, i d¿esdevenir lliures en la natura, phýsis, i no pas lluny o més enllà, metá, d¿ella.

La caverna de José Saramago: imagen platónica versus metafísica

La caverna de José Saramago tiene como referencia indudable la imagen de la caverna del libro VII de la República de Platón, y, sin embargo, Saramago no és un escritor idealista o metafísico. Este artículo muestra cómo, aprovechando la aplicabilidad con que Platón dotó a su imagen, Saramago defiende la necesidad de saber recibir los mensajes de la tierra, de la materia, de no convertirnos en prisioneros en las cavernas doradas de la sociedad occidental, y de ser libres en la naturaleza, phýsis, y no lejos o más allá, metá, de ella.

The Cave by José Saramago: Platonic image versus metaphysics

The cave by José Saramago has as a certain reference the image of the cave of book VII of Plato's Republic and, however, Saramago is not an idealistic or metaphysical writer. This article, taking advantage of the applicability with which Plato endowed his image, defends the urge to be open to the messages sent by the earth, by matter, the urge not to become prisoners in the golden caves of the Western society and, finally, the urge to find our freedom in Nature, phýsis, and not far or beyond, metá, it.

La caverna de José Saramago: imagen platónica versus metafísica

La caverna de José Saramago tiene como referencia indudable la imagen de la caverna del libro VII de la República de Platón, y, sin embargo, Saramago no és un escritor idealista o metafísico. Este artículo muestra cómo, aprovechando la aplicabilidad con que Platón dotó a su imagen, Saramago defiende la necesidad de saber recibir los mensajes de la tierra, de la materia, de no convertirnos en prisioneros en las cavernas doradas de la sociedad occidental, y de ser libres en la naturaleza, phýsis, y no lejos o más allá, metá, de ella.

Image restoration in astronomy: a Bayesian perspective

When preparing an article on image restoration in astronomy, it is obvious that some topics have to be dropped to keep the work at reasonable length. We have decided to concentrate on image and noise models and on the algorithms to find the restoration. Topics like parameter estimation and stopping rules are also commented on. We start by describing the Bayesian paradigm and then proceed to study the noise and blur models used by the astronomical community. Then the prior models used to restore astronomical images are examined. We describe the algorithms used to find the restoration for the most common combinations of degradation and image models. Then we comment on important issues such as acceleration of algorithms, stopping rules, and parameter estimation. We also comment on the huge amount of information available to, and made available by, the astronomical community.

Regulation of GABA(A) and glutamate receptor expression, synaptic facilitation and long-term potentiation in the hippocampus of prion mutant mice

Background: Prionopathies are characterized by spongiform brain degeneration, myoclonia, dementia, and periodic electroencephalographic (EEG) disturbances. The hallmark of prioniopathies is the presence of an abnormal conformational isoform (PrP(sc)) of the natural cellular prion protein (PrP(c)) encoded by the Prnp gene. Although several roles have been attributed to PrP(c), its putative functions in neuronal excitability are unknown. Although early studies of the behavior of Prnp knockout mice described minor changes, later studies report altered behavior. To date, most functional PrP(c) studies on synaptic plasticity have been performed in vitro. To our knowledge, only one electrophysiological study has been performed in vivo in anesthetized mice, by Curtis and coworkers. They reported no significant differences in paired-pulse facilitation or LTP in the CA1 region after Schaffer collateral/commissural pathway stimulation. Principal Findings: Here we explore the role of PrP(c) expression in neurotransmission and neural excitability using wild-type, Prnp -/- and PrP(c)-overexpressing mice (Tg20 strain). By correlating histopathology with electrophysiology in living behaving mice, we demonstrate that both Prnp -/- mice but, more relevantly Tg20 mice show increased susceptibility to KA, leading to significant cell death in the hippocampus. This finding correlates with enhanced synaptic facilitation in paired-pulse experiments and hippocampal LTP in living behaving mutant mice. Gene expression profiling using Illumina microarrays and Ingenuity pathways analysis showed that 129 genes involved in canonical pathways such as Ubiquitination or Neurotransmission were co-regulated in Prnp -/- and Tg20 mice. Lastly, RT-qPCR of neurotransmission-related genes indicated that subunits of GABA(A) and AMPA-kainate receptors are co-regulated in both Prnp -/- and Tg20 mice. Conclusions/Significance: Present results demonstrate that PrP(c) is necessary for the proper homeostatic functioning of hippocampal circuits, because of its relationships with GABA(A) and AMPA-Kainate neurotransmission. New PrP(c) functions have recently been described, which point to PrP(c) as a target for putative therapies in Alzheimer's disease. However, our results indicate that a "gain of function" strategy in Alzheimer's disease, or a "loss of function" in prionopathies, may impair PrP(c) function, with devastating effects. In conclusion, we believe that present data should be taken into account in the development of future therapies.

Constraints on additional Z' gauge bosons from a precise measurement of the Z mass

We analyze the constraints on the mass and mixing of a superstring-inspired E6 Z' neutral gauge boson that follow from the recent precise Z mass measurements and show that they depend very sensitively on the assumed value of the W mass and also, to a lesser extent, on the top-quark mass.

Seasonal dependence in the solar neutrino flux

Mikheyev-Smirnov-Wolfenstein (MSW) solutions of the solar neutrino problem predict a seasonal dependence of the zenith angle distribution of the event rates, due to the nonzero latitude at the Super-Kamiokande site. We calculate this seasonal dependence and compare it with the expectations in the no-oscillation case as well as just-so scenario, in the light of the latest Super-Kamiokande 708-day data. The seasonal dependence can be sizable in the large mixing angle MSW solution and would be correlated with the day-night effect. This may be used to discriminate between MSW and just-so scenarios and should be taken into account in refined fits of the data.

Don Martín Vallejo Lobón: el médico y el hombre

L'obra és una biografia completa i extensa del doctor Martín Vallejo Lobón, que fou catedràtic de Patologia Mèdica a la Universitat de Barcelona entre els anys 1902 i 1919.

Sociología de las profesiones sanitarias en Mérida: 1700-1833

A més d'un cens dels professionals sanitaris, en aquest llibre es porta a terme un estudi profund de la seva mentalitat, del nepotisme existent entre ells, els privilegis, la jerarquització i els contractes salarials. L'autor també fa una anàlisi de l'origen geogràfic d'aquests professionals i de la seva extracció social. Tot plegat sorgeix de l'estudi d'arxius municipals i parroquials.

Las Topografías médicas burgalesas : 1884-1917. Un intento de contribución a la historia natural, social y sanitaria de la província de Burgos en los siglos XIX y XX

Aquest és un dels treballs de López Gómez que s'insereix en la línia d'estudi de les topografies mèdiques com a material molt útil per al¿estudi de la història de la medicina a nivell local. En aquest cas estudia les topografies mèdiques de la província de Burgos a partir de documents conservats a l¿Arxiu de la Reial Acadèmia de Medicina de Barcelona. També inclou un petit estudi sobre la biografia i obra del doctor Ildefonso Díez Santaolalla (1851-1929).

La Topografía médica de Vic de Antonio Millet: 1798

En primer lloc, aquest llibre conté una traducció i transcripció de la Topografia Mèdica de Vic, d'Antoni Millet, de 1798. Aquesta transcripció es completa amb una investigació analítica i detallada del context cultural en què sorgiren les primeres topografies mèdiques al nostre país.El present document suposa el redescobriment d'una figura rellevant de la medicina catalana, Antoni Millet, de qui també es recull una segona obra entorn a una epidèmia que afectà la ciutat de Ripoll l'any 1790.