Expressive concatenative synthesis by reusing samples from real performance recordings

Here we describe an approach to the expressive synthesis of jazz saxophone melodies that reuses audio recordings and carefully concatenates note samples. The aim is to generate an expressive audio sequence from the analysis of an arbitrary input score using a previously induced performance model and an annotated saxophone note database extracted from real performances. We push the idea of using the same corpus for both inducing an expressive performance model and synthesizing sound by concatenating samples in the corpus. Therefore, a connection between the performers’ instrument sound and performance characteristics is kept during the synthesis process.

Ash2 acts as an Ecdysone Receptor coactivator by stabilizing the histone methyltransferase Trr.

The molting hormone ecdysone triggers chromatin changes via histone modifica- tions that are important for gene regulation. On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trithorax-related protein (Trr). Methylation of histone H3 at lysine 4 (H3K4me), which is associated with tran- scriptional activation, requires several cofactors, including Ash2. We find that ash2 mutants have severe defects in pupariation and metamorphosis due to a lack of activation of ecdy- sone-responsive genes. This transcriptional defect is caused by the absence of the H3K4me3 marks set by Trr in these genes. We present evidence that Ash2 interacts with Trr and is re- quired for its stabilization. Thus we propose that Ash2 functions together with Trr as an ecdysone receptor coactivator.