Singular integrals on Ahlfors-David regular subsets of the Heisenberg group

"Vegeu el resum a l'inici del document del fitxer adjunt."

I si deixem de parlar de preservació digital? Variacions sobre un tema de David Rosenthal, amb un poutpourri final amb la CDLib Orchestra

La preservació digital de la que parla la nostra literatura professional està plena de mites que pensem que s'han d'anar tombant un darrera l'altre, en aquesta presentació us els mencionarem.

La Llengua de l'heroi: notes sobre la llengua del segle XX a partir de les traduccions catalanes de David Copperfield de Charles Dickens

Estudi comparatiu de les dues traduccions catalanes publicades de David Copperfield de Charles Dickens. La primera de Josep Carner feta l’any 1930 però publicada el 1964 i la segona obra deJoan Sellent del 2003. L’anàlisi mostra que ambdues traduccions, excel·lents, reflecteixen una evolució singular i força accelerada del model de llengua que els traductors fan arribar al seu públic, que és reflex de la complexa història de la llengua catalana del segle xx, que encara s’had’escriure.

Impaired fast-spiking, suppressed cortical inhibition and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins

Voltage-gated K+ channels of the Kv3 subfamily have unusual electrophysiological properties, including activation at very depolarized voltages (positive to −10 mV) and very fast deactivation rates, suggesting special roles in neuronal excitability. In the brain, Kv3 channels are prominently expressed in select neuronal populations, which include fast-spiking (FS) GABAergic interneurons of the neocortex, hippocampus, and caudate, as well as other high-frequency firing neurons. Although evidence points to a key role in high-frequency firing, a definitive understanding of the function of these channels has been hampered by a lack of selective pharmacological tools. We therefore generated mouse lines in which one of the Kv3 genes, Kv3.2, was disrupted by gene-targeting methods. Whole-cell electrophysiological recording showed that the ability to fire spikes at high frequencies was impaired in immunocytochemically identified FS interneurons of deep cortical layers (5-6) in which Kv3.2 proteins are normally prominent. No such impairment was found for FS neurons of superficial layers (2-4) in which Kv3.2 proteins are normally only weakly expressed. These data directly support the hypothesis that Kv3 channels are necessary for high-frequency firing. Moreover, we found that Kv3.2 −/− mice showed specific alterations in their cortical EEG patterns and an increased susceptibility to epileptic seizures consistent with an impairment of cortical inhibitory mechanisms. This implies that, rather than producing hyperexcitability of the inhibitory interneurons, Kv3.2 channel elimination suppresses their activity. These data suggest that normal cortical operations depend on the ability of inhibitory interneurons to generate high-frequency firing.

Supersymmetric black rings and three-charge supertubes

We present supergravity solutions for 1/8-supersymmetric black supertubes with three charges and three dipoles. Their reduction to five dimensions yields supersymmetric black rings with regular horizons and two independent angular momenta. The general solution contains seven independent parameters and provides the first example of nonuniqueness of supersymmetric black holes. In ten dimensions, the solutions can be realized as D1-D5-P black supertubes. We also present a worldvolume construction of a supertube that exhibits three dipoles explicitly. This description allows an arbitrary cross section but captures only one of the angular momenta.

A Supersymmetric black ring

A new supersymmetric black hole solution of five-dimensional supergravity is presented. It has an event horizon of topology S1 X S2. This is the first example of a supersymmetric, asymptotically flat black hole of nonspherical topology. The solution is uniquely specified by its electric charge and two independent angular momenta. These conserved charges can be arbitrarily close, but not exactly equal, to those of a supersymmetric black hole of spherical topology.

Bivalirudin for patients with acute coronary syndromes

Background: Current guidelines for patients with moderate- or high-risk acute coronary syndromes recommend an early invasive approach with concomitant antithrombotic therapy, including aspirin, clopidogrel, unfractionated or low-molecular-weight heparin, and glycoprotein IIb/IIIa inhibitors. We evaluated the role of thrombin-specific anticoagulation with bivalirudin in such patients. Methods: We assigned 13,819 patients with acute coronary syndromes to one of three antithrombotic regimens: unfractionated heparin or enoxaparin plus a glycoprotein IIb/IIIa inhibitor, bivalirudin plus a glycoprotein IIb/IIIa inhibitor, or bivalirudin alone. The primary end points were a composite ischemia end point (death, myocardial infarction, or unplanned revascularization for ischemia), major bleeding, and the net clinical outcome, defined as the combination of composite ischemia or major bleeding. Results: Bivalirudin plus a glycoprotein IIb/IIIa inhibitor, as compared with heparin plus a glycoprotein IIb/IIIa inhibitor, was associated with noninferior 30-day rates of the composite ischemia end point (7.7% and 7.3%, respectively), major bleeding (5.3% and 5.7%), and the net clinical outcome end point (11.8% and 11.7%). Bivalirudin alone, as compared with heparin plus a glycoprotein IIb/IIIa inhibitor, was associated with a noninferior rate of the composite ischemia end point (7.8% and 7.3%, respectively; P = 0.32; relative risk, 1.08; 95% confidence interval [CI], 0.93 to 1.24) and significantly reduced rates of major bleeding (3.0% vs. 5.7%; P<0.001; relative risk, 0.53; 95% CI, 0.43 to 0.65) and the net clinical outcome end point (10.1% vs. 11.7%; P = 0.02; relative risk, 0.86; 95% CI, 0.77 to 0.97). Conclusions: In patients with moderate- or high-risk acute coronary syndromes who were undergoing invasive treatment with glycoprotein IIb/IIIa inhibitors, bivalirudin was associated with rates of ischemia and bleeding that were similar to those with heparin. Bivalirudin alone was associated with similar rates of ischemia and significantly lower rates of bleeding. (ClinicalTrials.gov number, NCT00093158.)

Mano a mano con David Roas

El escritor David Roas acaba de publicar su novela La estrategia del koala (Barcelona, Candaya, 2013, 234 pp.). Le pedimos que nos desvele alguno de sus entresijos, y la novela se vuelve aún más sugerente. En alguna de sus respuestas nos parece seguir escuchando a su personaje Marcos Fontana

Characterisation of COPD heterogeneity in the ECLIPSE cohort

Background Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE). Methods We studied 2164 clinically stable COPD patients, 337 smokers with normal lung function and 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, and amount of emphysema by computed tomography. Results COPD patients were slightly older than controls and had more pack years of smoking than smokers with normal lung function. Co-morbidities were more prevalent in COPD patients than in controls, and occurred to the same extent irrespective of the GOLD stage. The severity of airflow limitation in COPD patients was poorly related to the degree of breathlessness, health status, presence of co-morbidity, exercise capacity and number of exacerbations reported in the year before the study. The distribution of these variables within each GOLD stage was wide. Even in subjects with severe airflow obstruction, a substantial proportion did not report symptoms, exacerbations or exercise limitation. The amount of emphysema increased with GOLD severity. The prevalence of bronchiectasis was low (4%) but also increased with GOLD stage. Some gender differences were also identified. Conclusions The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.

La (De)construcció de la masculinitat en el teatre de David Mamet

La reflexió efectuada per la teoria contemporania sobre la representació del genere es materialitza d'una manera privilegiada en el teatre. Esta clar que la perforrnativitat intrinseca del fenomen teatral és un espai idoni per qüestionar la construcció de la representació generica. No hi ha dubte que I'especificitat comunicativa del teatre es troba en la «fisicalitat)): I'element corporal té una importancia clau, ja síguí per la presencia física de I'equip actoral i del públic i per la condició efímera (el fet que cap representació no és igual a cap altra). Judith Butler ha escrit sobre el fet que els actes que constitueixen el genere tenen un paral.lelisrne en les actes performatius dels contextos teatrals. La identitat de genere no és una identitat completa, sinó que és una identitat que es construeix, una realització performativa en la qual creiern, i que representem corn si fos una creenca, com si fos una qüestió de fe. Per tant, les possibilitats de transformació del genere es troben en la relació arbitraria d'aquests actes i en la possibilitat d'un altre tipus de repetició (Butler, 1990: 33). L'obra del dramaturg, director, guionista i assagista nord-america David Marnet pot considerar-se una reflexió sobre la construcció de la masculinitat i, de retruc, de les tensions i reptes a que la masculinitat es troba sotmesa en el tornbant de segle. 1. ES

Adaptació cinematogràfica de la novel·la Cuatro amigos de David Trueba

Aquest treball és una adaptació d'una obra literària a guió cinematogràfic d'un llargmetratge.

La llengua de l’heroi : notes sobre la llengua del segle xx a partir de les traduccions catalanes de David Copperfield de Charles Dickens

A comparative study of the two published Catalan translations of Charles Dickens’ David Copperfield, the first translated by Josep Carner in 1930 but not published until 1964, and the second by Joan Sellent in 2003. The analysis shows that both translations, magnificent, reflect the unique evolution of the language model that the translators pass on to their readers, an evolution shaped by the complex history of the Catalan language in the 20th century, which is still to be written

David Roas, La estrategia del koala. (Ressenya)

¿Cómo encaja esta última obra del Roas escritor en una trayectoria que parece tan homogénea y definitoria de su estilo como la esbozada más arriba? ¿Se encontrará el lector que se acerque a La estrategia del koala con una nueva exploración de las posibilidades de lo fantástico?

L'impacte de la iconografia musical en les dinàmiques socials : David Bowie o el poder social de les imatges musicals

El present treball de recerca posa de relleu que la música és un element fonamental de la configuració de les societats humanes actuals i analitza un cas concret, el de l'artista britànic David Bowie, per il·lustrar els mecanismes pels quals un artista pot convertir-se en una icona i, d'aquesta manera, influir decissivament en la configuració d'elements de l'imaginari social compartit.