Hölderlin, un proyecto emancipatorio fracasado

Se analiza a Holderlin en contraposición con el proyecto especulativoracionalista hegeliano y, a la vez, el romanticismo más elitista, apolítico y ególatra, pero sin caer en las interpretaciones próximas al nazismo. Así, su canto responde a la noción de "alma bella", pues no está dispuesto a condescender con nada que represente una claudicación en su aspiraciónal absoluto -planteado como ideal emancipatorio global-. Lo divino o la infinitud son los nombres del elemento emancipador que elevaa los hombres sobre sí y los hace vivir como dioses. Ahora bien, las dificultades intrínsecas de dicho proyecto no se le escapan a Holderlin,incluso podemos decir que las enfrenta con radicalidad sin igual. El poeta asume esa lucha -tan desesperada como entusiasta- por enlazar finitude infinitud, por hacer divinos a los hombres. Por ello, la conciencia de la inevitabilidad del fracaso último preside la tragicidad de su pensamiento.Su canto manifiesta inevitablemente un ritmo intermitente entre el entusiasmo vivificador y volcado sobre el proyecto emancipatorio y laretirada lastimera consecuencia del fracaso pero, solamente, para reintentarlo con renovada fuerza.

Friedrich Nietzsche i Oscar Wilde : la qüestió humana, una anàlisi comparada

Anàlisi comparativa de l'obra de Nietzsche i de Wilde en relació als eixos de la vida, l'home i la societat. S'analitza com ambdós autors intenten de fer l'home més humà i quines mesures proposen, la qual cosa implica tractar també què s'entén per vida (dimensió individual) i com l'home s'ha de relacionar amb la resta de la humanitat (dimensió social).

Consens i revolució: Poble i nació a la Barcelona de la Revolució Liberal, 1835-1843

Anàlisi dels deferents discursos de moderats, progressistes i republicans i els usos dels mots “poble” i “nació” durant els anys 1837-1843. L’autor considera que aquesta perspectiva és important per entendre el període, tot i que els recents debats sobre els orígens del nacionalisme a Espanya ho han deixat en un lloc secundari

Involvement of Dab1 in APP processing and [beta]-amyloid deposition in sporadic Creutzfeldt-Jakob patients.

Alzheimer"s disease and prion pathologies (e.g., Creutzfeldt-Jakob disease) display profound neural lesions associated with aberrant protein processing and extracellular amyloid deposits. For APP processing, emerging data suggest that the adaptor protein Dab1 plays a relevant role in regulating its intracellular trafficking and secretase-mediated proteolysis. Although some data have been presented, a putative relationship between human prion diseases and Dab1/APP interactions is lacking. Therefore, we have studied the putative relation between Dab1, APP processing and Aβ deposition, targets in sCJD cases. Our biochemical results categorized two groups of sCJD cases, which also correlated with PrPsc types 1 and 2 respectively. One group, with PrPsc type 1 showed increased Dab1 phosphorylation, and lower βCTF production with an absence of Aβ deposition. The second sCJD group, which carried PrPsc type 2, showed lower levels of Dab1 phosphorylation and βCTF production, similar to control cases. Relevant Aβ deposition in the second sCJD group was measured. Thus, a direct correlation between Dab1 phosphorylation, Aβ deposition and PrPsc type in human sCJD is presented for the first time.

Friedrich Hölderlin en la obra de Luis Cernuda

Cernuda tradujo a Hölderlin sin saber alemán, sin ser traductor. La obra de Hölderlin apenas era conocida y casi no había sido editada en lengua española. ¿Cómo lo hizo? ¿Realmente influyó la obra del poeta alemán en su poesía, como él lo afirmaba? He aquí una aproximación a estas cuestiones

L'Anatomia artística a l"Escola de Belles Arts de Barcelona. Els casos de Jeroni Faraudo (1823-1886) i de Tiberio Ávila (1843-1932)

[cat] Aquest article se centra en la significació i transcendència de l"assignatura d"Anatomia artística a l"Escola de Belles Arts de Barcelona durant la segona meitat del segle XIX i principis de segle XX. S"empren, com a fil conductor, les figures de Jeroni Faraudo i Condeminas (1823-1886) i de Tiberio Ávila Rodríguez (1843-1932), els dos primers professors que impartiren la matèria i que romanen, en l"actualitat, pràcticament inèdits. El coneixement de l"ideari de Faraudo i d"Ávila permet completar el panorama de l"evolució de les idees estètiques a la Catalunya del moment i, alhora, contribueix a la comprensió de l"erosió de la primacia de l"antic en l"aprenentatge oficial de les arts a Catalunya. [spa] Este artículo se centra en la significación y transcendencia de la asignatura de Anatomía artística en la Escuela de Bellas Artes de Barcelona durante la segunda mitad del siglo XIX y principios de siglo XX. Se emplean, como hilo conductor, las figuras de Gerónimo Faraudo Condeminas (1823-1886) y de Tiberio Ávila Rodríguez (1843-1932), los dos primeros profesores que impartieron la materia y que permanecen, en la actualidad, prácticamente inéditos. El conocimiento del ideario de Faraudo y de Ávila permite completar el panorama de la evolución de las ideas estéticas en la Cataluña del momento y, al mismo tiempo, contribuye a la comprensión de la erosión de la primacía del antiguo en el aprendizaje oficial de las artes en Cataluña. [eng]This article focuses on the subject of Artistic Anatomy at the Barcelona School of Fine Arts during the second half of the 19th and early 20th centuries, discussing its signification. The connecting thread of this article are Jeroni Faraudo i Condeminas (1823-1886) and Tiberio Ávila Rodríguez (1843-1932), its first two teachers, who remain nowadays practically unknown. The knowledge of their ideas completes the history of contemporary Catalan aesthetics and also contributes to the comprehension of the erosion in the primacy of the use of ancient models in the official artistic teaching in Catalonia.

APP processing and b-amyloid deposition in sporadic Creutzfeldt-Jakob patients is dependent on Dab1.

Alzheimer"s disease and prion pathologies (e.g., Creutzfeldt-Jakob disease (CJD)) display profound neural lesions associated with aberrant protein processing and extracellular amyloid deposits. Dab1 has been implicated in the regulation of Amyloid Precursor Protein (APP), but a direct link between human prion diseases and Dab1/APP interactions has not been published. Here we examined this putative relationship in seventeen cases of sporadic CJD (sCJD) post mortem. Biochemical analyses of brain tissue revealed two groups, which also correlated with PrPsc types 1 and 2. One group, with PrPsc type 1 showed increased Dab1 phosphorylation, and lower CTF production with an absence of A deposition. The second sCJD group, which carried PrPsc type 2, showed lower levels of Dab1 phosphorylation and CTF production, and A deposition. Thus, the present observations suggest a correlation between Dab1-phosphorylation, A deposition and PrPsc type in sCJD.

Coexistence of protease sensitive and resistant prion protein in 129VV homozygous sporadic Creutzfeldt-Jakob disease: a case report

Introduction: The coexistence of different molecular types of classical protease-resistant prion protein in the same individual have been described, however, the simultaneous finding of these with the recently described protease-sensitive variant or variably protease-sensitive prionopathy has, to the best of our knowledge, not yet been reported. Case presentation: A 74-year-old Caucasian woman showed a sporadic Creutzfeldt-Jakob disease clinical phenotype with reactive depression, followed by cognitive impairment, akinetic-rigid Parkinsonism with pseudobulbar syndrome and gait impairment with motor apraxia, visuospatial disorientation, and evident frontal dysfunction features such as grasping, palmomental reflex and brisk perioral reflexes. She died at age 77. Neuropathological findings showed: spongiform change in the patient"s cerebral cortex, striatum, thalamus and molecular layer of the cerebellum with proteinase K-sensitive synaptic-like, dot-like or target-like prion protein deposition in the cortex, thalamus and striatum; proteinase K-resistant prion protein in the same regions; and elongated plaque-like proteinase K-resistant prion protein in the molecular layer of the cerebellum. Molecular analysis of prion protein after proteinase K digestion revealed decreased signal intensity in immunoblot, a ladder-like protein pattern, and a 71% reduction of PrPSc signal relative to non-digested material. Her cerebellum showed a 2A prion protein type largely resistant to proteinase K. Genotype of polymorphism at codon 129 was valine homozygous. Conclusion: Molecular typing of prion protein along with clinical and neuropathological data revealed, to the best of our knowledge, the first case of the coexistence of different protease-sensitive prion proteins in the same patient in a rare case that did not fulfill the current clinical diagnostic criteria for either probable or possible sporadic Creutzfeldt-Jakob disease. This highlights the importance of molecular analyses of several brain regions in order to correctly diagnose rare and atypical prionopathies

A common BACE1 polymorphism is a risk factor for sporadic Creutzfeldt-Jakob disease

The β site APP cleaving enzyme 1 (BACE1) is the rate-limiting β-secretase enzyme in the amyloidogenic processing of APP and Aβ formation, and therefore it has a prominent role in Alzheimer"s disease (AD) pathology. Recent evidence suggests that the prion protein (PrP) interacts directly with BACE1 regulating its β-secretase activity. Moreover, PrP has been proposed as the cellular receptor involved in the impairment of synaptic plasticity and toxicity caused by Aβ oligomers. Provided that common pathophysiologic mechanisms are shared by Alzheimer"s and Creutzfeldt-Jakob (CJD) diseases, we investigated for the first time to the best of our knowledge a possible association of a common synonymous BACE1 polymorphism (rs638405) with sporadic CJD (sCJD). Our results indicate that BACE1 C-allele is associated with an increased risk for developing sCJD, mainly in PRNP M129M homozygous subjects with early onset. These results extend the very short list of genes (other than PRNP) involved in the development of human prion diseases; and support the notion that similar to AD, in sCJD several loci may contribute with modest overall effects to disease risk. These findings underscore the interplay in both pathologies of APP, Aβ oligomers, ApoE, PrP and BACE1, and suggest that aging and perhaps vascular risk factors may modulate disease pathologies in part through these key players

L'Anatomia artística a l"Escola de Belles Arts de Barcelona. Els casos de Jeroni Faraudo (1823-1886) i de Tiberio Ávila (1843-1932)

[cat] Aquest article se centra en la significació i transcendència de l"assignatura d"Anatomia artística a l"Escola de Belles Arts de Barcelona durant la segona meitat del segle XIX i principis de segle XX. S"empren, com a fil conductor, les figures de Jeroni Faraudo i Condeminas (1823-1886) i de Tiberio Ávila Rodríguez (1843-1932), els dos primers professors que impartiren la matèria i que romanen, en l"actualitat, pràcticament inèdits. El coneixement de l"ideari de Faraudo i d"Ávila permet completar el panorama de l"evolució de les idees estètiques a la Catalunya del moment i, alhora, contribueix a la comprensió de l"erosió de la primacia de l"antic en l"aprenentatge oficial de les arts a Catalunya. [spa] Este artículo se centra en la significación y transcendencia de la asignatura de Anatomía artística en la Escuela de Bellas Artes de Barcelona durante la segunda mitad del siglo XIX y principios de siglo XX. Se emplean, como hilo conductor, las figuras de Gerónimo Faraudo Condeminas (1823-1886) y de Tiberio Ávila Rodríguez (1843-1932), los dos primeros profesores que impartieron la materia y que permanecen, en la actualidad, prácticamente inéditos. El conocimiento del ideario de Faraudo y de Ávila permite completar el panorama de la evolución de las ideas estéticas en la Cataluña del momento y, al mismo tiempo, contribuye a la comprensión de la erosión de la primacía del antiguo en el aprendizaje oficial de las artes en Cataluña. [eng]This article focuses on the subject of Artistic Anatomy at the Barcelona School of Fine Arts during the second half of the 19th and early 20th centuries, discussing its signification. The connecting thread of this article are Jeroni Faraudo i Condeminas (1823-1886) and Tiberio Ávila Rodríguez (1843-1932), its first two teachers, who remain nowadays practically unknown. The knowledge of their ideas completes the history of contemporary Catalan aesthetics and also contributes to the comprehension of the erosion in the primacy of the use of ancient models in the official artistic teaching in Catalonia.