23 resultados para Exposición Regional Valenciana (1ª. 1909. València)
em Consorci de Serveis Universitaris de Catalunya (CSUC), Spain
Resumo:
This paper analyzes the growth and employment effects of the 1994-99 Community Support Framework (CSF) for the Objective 1 Spanish regions using a simple supply-side model estimated with a panel of regional data. The results suggest that the impact of the Structural Funds in Spain has been quite sizable, adding around a percentage point to annual output growth in the average Objective 1 region and 0.4 points to employment growth. Over the period 1994-2000, the Framework has resulted in the creation of over 300,000 new jobs and has eliminated 20% of the initial gap in income per capita between the assisted regions and the rest of the country.
Resumo:
La 3,4-Metilendioximetanfetamina (MDMA, xtasis) es un derivado anfetamnico sinttico ampliamente usado como droga recreativa, que produce neurotoxicidad serotonrgica en animales y posiblemente tambin en humanos. El mecanismo subyacente de neurotoxicidad, incluye la formacin de especies reactivas de oxigeno (ROS), pero la fuente de generacin de estos es un punto de controversia. Se postula que la neurotoxicidad inducida por la MDMA es mediada por la formacin de metabolitos bioreactivos. Especficamente, los metabolitos primarios de tipo catecol, la 3,4- dihidroximetanfetamina (HHMA) y la 3,4-dihidroxianfetamina (HHA), que luego dan lugar a la formacin de conjugados con el glutatin y la N-acetilcistena, y que conservan la capacidad de entrar en el ciclo redox y presentan neurotoxicidad serotonrgica en ratas. Aunque la presencia de dichos metabolitos se demostr recientemente en microdialisados de cerebros de ratas, su formacin en humanos no se ha reportado aun. Este trabajo describe la deteccin de N-acetil-cistena-HHMA (NAC-HHMA) y N-acetil-cistena-HHA (NAC-HHA) en orina humana de 15 consumidores recreacionales de MDMA (1.5 mg/kg) en un entorno controlado. Los resultados revelan que en las primeras 4 horas despus del consumo de MDMA aproximadamente el 0.002% de la dosis administrada es recuperada como aductos tioter. Los polimorfismos genticos en la expresin de las enzimas CYP2D6 y COMT, que en conjunto son las principales determinantes de los niveles estables de HHMA y HHA, posiblemente expliquen la variabilidad interindividual observada en la recuperacin de la NAC-HHMA y la NAC-HHA en orina. Resumiendo, por primera vez se demuestra la formacin de aductos tioteres neurotxicos de la MDMA en humanos. Estos resultados apoyan la hiptesis de que la bioactivacin de la MDMA a metabolitos neurotxicos es el mecanismo relevante para la generacin de la neurotoxicidad en humanos.
Resumo:
I construct "homogeneous" series of GVA at current and constant prices, employment and population for the Spain and its regions covering the period 1955-2007. The series are obtained by linking the Regional Accounts of the National Statistical Institute with the series constructed by Julio Alcaide and his team for the BBVA Foundation. The "switching point" at which this last source stops being used as a reference to construct the linked series is determined using a procedure that allows me to estimate which of the two competing series would produce an estimator with the lowest MSE when it is used as dependent variable in a regression on an arbitrary independent variable. To the extent that it is possible, the difference between the two series found at the point of linkage is distributed between the initial levels of the older series and its subsequent growth using external estimates of the relevant variables at the beginning of the sample period.
Resumo:
Aquest treball de recerca est encaminat a la sntesi de lligands tipus catecol fluorescents, els quals, un cop units a un i metllic adient, podran presentar tautomerisme de valència, i aix permetre la sntesi dinterruptors moleculars fluorescents basats en tautmers de valència. La sntesi daquests lligands parteix del 4-metil-2-metoxifenol com a esquelet catecol que, mitjanant una srie de reaccions, ha condut a lintermedi 1, intermedi clau per a la preparaci de diferents lligands tipus catecol. A partir daquest intermedi 1 shan sintetitzat dos lligands tipus catecol diferents: el lligand model 2, que servir per assajar reaccions de complexaci, i un de fluorescent. Desprs dexplorar diferents rutes sinttiques encaminades a la preparaci daquest segon tipus de lligand, sha obtingut el compost 20.
Resumo:
El cluster Medicon Valley es troba a la regi d'Oresund binacional que s'estn per Dinamarca i Sucia, inclosa la Universitat de Lund, ciutat i tercera ciutat ms gran de Sucia, Malm (veure figura 1). El 2000, aquestes dues parts nacionals estaven connectades fsicament per l'establiment dels 18 quilmetres de longitud, enlla fix del resund (ponts i tnels).
Resumo:
In this paper I explore two hypotheses: (1) Formal child care availability for children under three has a positive effect across contexts, according to the degree of adaptation of social institutions to changes in gender roles. Event history models with regional fixed effects are applied to data from the European Community Household Panel (1994-2001). The results show a significant and positive effect of regional day care availability on both, first and higher order births, while results are consistent with the second hypothesis only for second or higher order births.
Resumo:
This paper addresses three questions: (1) why does the share of skilledworkers in regional population tend to be higher in wealthier regions? (2)what determines changes in this share over time? and (3) why is it that internalmigration tends to raise average skill levels of the receiving regions relativeto that of the sending regions? I construct a two--region dynamic model withagglomeration and congestion to answer these questions. It is shown that,under certain relationship between wages and demand for land, unskilledworkers are discouraged more strongly from living in a wealthier region andare less mobile than skilled workers.
Resumo:
We apply a multilevel hierarchical model to explore whether anaggregation fallacy exists in estimating the income elasticity of healthexpenditure by ignoring the regional composition of national healthexpenditure figures. We use data for 110 regions in eight OECD countriesin 1997: Australia, Canada, France, Germany, Italy, Spain, Sweden andUnited Kingdom. In doing this we have tried to identify two sources ofrandom variation: within countries and between-countries. Our resultsshow that: 1- Variability between countries amounts to (SD) 0.5433, andjust 13% of that can be attributed to income elasticity and the remaining87% to autonomous health expenditure; 2- Within countries, variabilityamounts to (SD) 1.0249; and 3- The intra-class correlation is 0.5300. Weconclude that we have to take into account the degree of fiscaldecentralisation within countries in estimating income elasticity ofhealth expenditure. Two reasons lie behind this: a) where there isdecentralisation to the regions, policies aimed at emulating diversitytend to increase national health care expenditure; and b) without fiscaldecentralisation, central monitoring of finance tends to reduce regionaldiversity and therefore decrease national health expenditure.
Resumo:
En este artculo, partiendo de las pinturas de Juan de Juanes en lAlcdia, analizamos las cuestiones sociales que pudieron incidir en su produccin artstica, iconografa y difusin dentro del mbito valenciano. La posible influencia del erasmismo, la filosofa intimista, la cristologa de Eiximenis o el adoctrinamiento a los moriscos son algunos aspectos sobre los que centramos nuestra reflexin.
Resumo:
L'article analitza els primers autors (Pere Miquel Carbonell, Ermolao Barbaro, Jeroni Pau) i les primeres obres que citen inscripcions valencianes d'poca romana. Tot seguit es posa en relaci la informaci present en aquestes obres amb la tradici de l'Antiquus i de l'Antiquissimus. Es conclou que el coneixement sobre l'epigrafia valenciana en el primer Renaixement entre els cercles humanstics italians i catalans s molt ms ric i ms antic del que tradicionalment es creia.
Resumo:
Primera guia de materials lapidis hispnics explotats en poca romana a la pennsula Ibrica. El treball recull 16 varietats, i t especial inters en la descripci de la geologia dels entorns de les explotacions. Entre els materials lapidis figuren, per exemple, marbres de la zona dEstremoz (Portugal), broccatello (tamb anomanat jaspi de la Cinta, procedent de Tortosa), marbres de la zona de Macael (Andalusia) i la pedra de Buixcarr (València). Tamb s'hi estudien amb detall els punts dexplotaci (pedreres) i les diverses aplicacions donades a cada tipus de pedra. El llibre s trilinge (angls, catal i castell), est molt ben illustrat (en color) i s'ha publicat com a catleg ampliat d'una exposici amb el mateix ttol muntada en el marc de la IX Asmosia Internacional Conference (Tarragona, juny del 2009).
Resumo:
En el presente proyecto La Trompeta en la C. Valenciana se pretende dar la visin global de la Trompeta dentro de la historia de la msica y ms especficamente dentro de Valencia. El trabajo incluye un apartado explicativo de los mejores maestros y pedagogos del instrumento, la ascendente historia de las Bandas en esta Comunidad, el repertorio e influencia que tienen los compositores de esta tierra para la Trompeta y el anlisis de las obras escogidas.
Resumo:
Background To analyse the extent and profile of outpatient regular dispensation of antipsychotics, both in combination and monotherapy, in the Barcelona Health Region (Spain), focusing on the use of clozapine and long-acting injections (LAI). Methods Antipsychotic drugs dispensed for people older than 18 and processed by the Catalan Health Service during 2007 were retrospectively reviewed. First and second generation antipsychotic drugs (FGA and SGA) from the Anatomical Therapeutic Chemical classification (ATC) code N05A (except lithium) were included. A patient selection algorithm was designed to identify prescriptions regularly dispensed. Variables included were age, gender, antipsychotic type, route of administration and number of packages dispensed. Results A total of 117,811 patients were given any antipsychotic, of whom 71,004 regularly received such drugs. Among the latter, 9,855 (13.9%) corresponded to an antipsychotic combination, 47,386 (66.7%) to monotherapy and 13,763 (19.4%) to unspecified combinations. Of the patients given antipsychotics in association, 58% were men. Olanzapine (37.1%) and oral risperidone (36.4%) were the most common dispensations. Analysis of the patients dispensed two antipsychotics (57.8%) revealed 198 different combinations, the most frequent being the association of FGA and SGA (62.0%). Clozapine was dispensed to 2.3% of patients. Of those who were receiving antipsychotics in combination, 6.6% were given clozapine, being clozapine plus amisulpride the most frequent association (22.8%). A total of 3.800 patients (5.4%) were given LAI antipsychotics, and 2.662 of these (70.1%) were in combination. Risperidone was the most widely used LAI. Conclusions The scant evidence available regarding the efficacy of combining different antipsychotics contrasts with the high number and variety of combinations prescribed to outpatients, as well as with the limited use of clozapine. Background To analyse the extent and profile of outpatient regular dispensation of antipsychotics, both in combination and monotherapy, in the Barcelona Health Region (Spain), focusing on the use of clozapine and long-acting injections (LAI). Methods Antipsychotic drugs dispensed for people older than 18 and processed by the Catalan Health Service during 2007 were retrospectively reviewed. First and second generation antipsychotic drugs (FGA and SGA) from the Anatomical Therapeutic Chemical classification (ATC) code N05A (except lithium) were included. A patient selection algorithm was designed to identify prescriptions regularly dispensed. Variables included were age, gender, antipsychotic type, route of administration and number of packages dispensed. Results A total of 117,811 patients were given any antipsychotic, of whom 71,004 regularly received such drugs. Among the latter, 9,855 (13.9%) corresponded to an antipsychotic combination, 47,386 (66.7%) to monotherapy and 13,763 (19.4%) to unspecified combinations. Of the patients given antipsychotics in association, 58% were men. Olanzapine (37.1%) and oral risperidone (36.4%) were the most common dispensations. Analysis of the patients dispensed two antipsychotics (57.8%) revealed 198 different combinations, the most frequent being the association of FGA and SGA (62.0%). Clozapine was dispensed to 2.3% of patients. Of those who were receiving antipsychotics in combination, 6.6% were given clozapine, being clozapine plus amisulpride the most frequent association (22.8%). A total of 3.800 patients (5.4%) were given LAI antipsychotics, and 2.662 of these (70.1%) were in combination. Risperidone was the most widely used LAI. Conclusions The scant evidence available regarding the efficacy of combining different antipsychotics contrasts with the high number and variety of combinations prescribed to outpatients, as well as with the limited use of clozapine.
Resumo:
Background Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic pathways, even in presence of oxygen, favoring the malignant aerobic glycolytic phenotype characteristic of tumor cells. As TKTL1 appears to be a valid biomarker for cancer prognosis, the aim of the current study was to correlate its expression with tumor stage, probability of tumor recurrence and survival, in a series of colorectal cancer patients. Methodolody/Principal Findings Tumor tissues from 63 patients diagnosed with colorectal cancer at different stages of progression were analyzed for TKTL1 by immunohistochemistry. Staining was quantified by computational image analysis, and correlations between enzyme expression, local growth, lymph-node involvement and metastasis were assessed. The highest values for TKTL1 expression were detected in the group of stage III tumors, which showed significant differences from the other groups (Kruskal-Wallis test, P = 0.000008). Deeper analyses of T, N and M classifications revealed a weak correlation between local tumor growth and enzyme expression (Mann-Whitney test, P = 0.029), a significant association of the enzyme expression with lymph-node involvement (Mann-Whitney test, P = 0.0014) and a significant decrease in TKTL1 expression associated with metastasis (Mann-Whitney test, P = 0.0004). Conclusions/Significance To our knowledge, few studies have explored the association between variations in TKTL1 expression in the primary tumor and metastasis formation. Here we report downregulation of enzyme expression when metastasis appears, and a correlation between enzyme expression and regional lymph-node involvement in colon cancer. This finding may improve our understanding of metastasis and lead to new and more efficient therapies against cancer.
Resumo:
Saint Vicent Ferrers personality (1350-1419) has been tackled by researchers in different points of view, and this has meant a proliferation of very diverse studies. There isnt much, however, the works which has done analysis relating to popular piety and devotion. In this sense, the different hagiographic sources puts us faced with a saint with a very widespread cult in some areas, for instance, the Crown of Aragon and Castille, but also in other european places. As for the last, we detect an import focus of devotion in Brittany, where the saint arrived to preach after being called by Jean V. He died at Vannes (1419), the political capital of the duchy of Brittany, and he was buried in Saint Pierres cathedral. Previously to his canonization, his fame as a miracle worker during his life was the reason for his tomb became a real locus sanctus, a place where pilgrims arrived to venerate his relics. These relics had healing and prophylactic properties. Apart from these ones, we have many references of contact relics with properties of this kind.
