Bases per crear un tractament de prevenció secundaria per pacients amb fuetada cervical

Projecte de recerca elaborat a partir d’una estada al departament d’anestesiologia de la University of Washington durant juliol i agost del 2006. La fuetada cervical és una lesió molt freqüent. Encara que els problemes associats es resolen en un període de temps curt en la majoria de casos, un percentatge de casos que oscil·la entre el 12 i el 42% desenvolupa dolor cervical crònic i discapacitat associada. Aquesta situació provoca un elevat cost econòmic per a la societat i un elevat patiment per a les persones que pateixen dolor crònic cervical i discapacitat com a conseqüència de la fuetada cervical. Ambdues conseqüències podrien ser evitades dissenyant estratègies de prevenció secundaria efectives. Aquest és precisament l’objectiu de la tesis del doctorant Aquesta va ser considerada essencial perquè en aquesta universitat esta l’únic grup de recerca que esta realitzant un tractament de prevenció secundaria per a pacients amb fuetada cervical. La realització de totes aquestes tasques ha permès al doctorant millorar el seu treball de recerca i començar a dissenyar un programa de prevenció secundaria per a la nostra població de pacients amb fuetada cervical. A més, s’han establert lligams de col·laboració.

Propuesta de programa de prevención de trastornos de la conducta alimentaria y la obesidad dirigido a profesores de educación física de secundaria

En la actual concepción bio-psico-social, los Trastornos del Comportamiento Alimentario (TCA) y la obesidad están plurideterminados por factores biológicos, psicológicos y socioculturales que actúan como elementos perpetuantes en el tiempo. Se pueden modificar actitudes contraproducentes con un programa de prevención multidisciplinar y disminuir de modo significativo la población con riesgo de obesidad y de padecer un TCA. Para ello, es necesario desarrollar dichos programas de prevención, previos a la atención primaria, y la estrategia para lograrlo es la intervención ante factores de riesgo, integrada en un conjunto de actividades de educación para la salud más global. Esta propuesta educativa pretende brindar a los profesores de Educación Física una revisión bibliográfica sobre la dimensión que desde la cultura occidental se tiene de los Trastornos del Comportamiento Alimentario (TCA) y la obesidad, al tiempo que promueve la reflexión sobre las posibilidades de intervención que ofrece la Educación Física desde el ámbito educativo en cuanto a la prevención de la obesidad, de los TCA, y de las conductas de riesgo. La presente propuesta de proyecto de prevención quiere destacar la función que cumplen docentes, tutores y tutoras, como acompañantes de los estudiantes, su posición privilegiada para conocerlos de cerca y estar así atentos a sus vivencias y la posibilidad de identificar oportunamente conductas no saludables en estudiantes que necesiten ciertas pautas para mejorar su estilo de vida, modificar sus habitos, o ser derivados para una atención especializada. Por ese motivo, en esta propuesta educativa se invita a los docentes y tutores a revisar sus convicciones personales y cuestionar la manera de pensar sobre la belleza física y el cuidado corporal. Esta reflexión junto a las pautas metodológicas permitirá abordar el tema de los TCA y la obesidad con tacto, respeto y la atención necesaria frente a los sentimientos de los y las estudiantes que se encuentran en un periodo de cambios importantes y con interrogantes en torno a su identidad e imagen corporal

La ment forma part de la teva vida, aprèn a cuidar-la!

L’objectiu d’aquest estudi és crear un programa de prevenció de la demència a partir d’activitats i ocupacions significatives. S’utilitzarà la metodologia quantitativa i es realitzarà un estudi experimental i seqüencial. L’estudi es realitzarà al medi rural, concretament a Ripoll (Sant Bernabé). Per tal de poder obtenir la els participants per la realització de l’estudi s’utilitzarà el mostreig aleatori estratificat amb el qual s’obtindrà dos grups de 16 persones de 50 a 55 anys. Els instruments que s’utilitzaran per tal de poder obtenir les dades de l’estudi són el “Qüestionari internacional d’activitat física” (2002), la bateria neuropsicològica anomenada “Test de Barcelona abreviat” (1997), “L’escala de qualitat de vida” (2008), i per acabar s’utilitzarà el “Test KIMED” (2004). Una primera limitació pot ser que l’ajuntament no ens faciliti les dades per tal de poder realitzar el mostreig aleatori estratificat per tal de poder aconseguir la mostra. També pot ser que l’ajuntament no cedeixi el lloc per tal de poder realitzar la intervenció. Un altre possible limitació pot ser el temps atmosfèric. I per acabar també ens podem torbar amb l’abandonament del programa per part d’un o més participants.

Oncobiguanides: Paracelsus" law and nonconventional routes for administering diabetobiguanides for cancer treatment

The dose makes the poison, the common motto of toxicology first expressed by Paracelsus more than 400 years ago, may effectively serve to guide potential applications for metformin and related biguanides in oncology. While Paracelsus' law for the dose-response effect has been commonly exploited for the use of some anti-cancer drugs at lower doses in non-neoplastic diseases (e.g., methotrexate), the opposite scenario also holds true; in other words, higher doses of non-oncology drugs, such as anti-diabetic biguanides, might exert direct anti-neoplastic effects. Here, we propose that, as for any drug, there is a dose range for biguanides that is without any effect, one corresponding to"diabetobiguanides" with a pharmacological effect (e.g., insulin sensitization in type 2 diabetes, prevention of insulin-dependent carcinogenesis, indirect inhibition of insulin and growth factor-dependent cancer growth) but with minimal toxicity and another corresponding to 'oncobiguanides' with pharmacological (i.e., direct and strong anticancer activity against cancer cells) as well as toxic effects. Considering that biguanides demonstrate a better safety profile than most oncology drugs in current use, we should contemplate the possibility of administering biguanides through non-conventional routes (e.g., inhaled for carcinomas of the lung, topical for skin cancers, intravenous as an adjunctive therapy, rectal suppositories for rectal cancer) to unambiguously investigate the therapeutic value of high-dose transient biguanide exposure in cancer. Perhaps then, the oncobiguanides, as we call them here, could be viewed as a mechanistically different type of anti-cancer drugs employed at doses notably higher than those used chronically when functioning as diabetobiguanides

Group motivational intervention in overweight/obese patients in primary prevention of cardiovascular disease in the primary healthcare area

Background The global mortality caused by cardiovascular disease increases with weight. The Framingham study showed that obesity is a cardiovascular risk factor independent of other risks such as type 2 diabetes mellitus, dyslipidemia and smoking. Moreover, the main problem in the management of weight-loss is its maintenance, if it is achieved. We have designed a study to determine whether a group motivational intervention, together with current clinical practice, is more efficient than the latter alone in the treatment of overweight and obesity, for initial weight loss and essentially to achieve maintenance of the weight achieved; and, secondly, to know if this intervention is more effective for reducing cardiovascular risk factors associated with overweight and obesity. Methods This 26-month follow up multi-centre trial, will include 1200 overweight/obese patients. Random assignment of the intervention by Basic Health Areas (BHA): two geographically separate groups have been created, one of which receives group motivational intervention (group intervention), delivered by a nurse trained by an expert phsychologist, in 32 group sessions, 1 to 12 fortnightly, and 13 to 32, monthly, on top of their standard program of diet, exercise, and the other (control group), receiving the usual follow up, with regular visits every 3 months. Discussion By addressing currently unanswered questions regarding the maintenance in weight loss in obesity/overweight, upon the expected completion of participant follow-up in 2012, the IMOAP trial should document, for the first time, the benefits of a motivational intervention as a treatment tool of weight loss in a primary care setting.

Group motivational intervention in overweight/obese patients in primary prevention of cardiovascular disease in the primary healthcare area

Background The global mortality caused by cardiovascular disease increases with weight. The Framingham study showed that obesity is a cardiovascular risk factor independent of other risks such as type 2 diabetes mellitus, dyslipidemia and smoking. Moreover, the main problem in the management of weight-loss is its maintenance, if it is achieved. We have designed a study to determine whether a group motivational intervention, together with current clinical practice, is more efficient than the latter alone in the treatment of overweight and obesity, for initial weight loss and essentially to achieve maintenance of the weight achieved; and, secondly, to know if this intervention is more effective for reducing cardiovascular risk factors associated with overweight and obesity. Methods This 26-month follow up multi-centre trial, will include 1200 overweight/obese patients. Random assignment of the intervention by Basic Health Areas (BHA): two geographically separate groups have been created, one of which receives group motivational intervention (group intervention), delivered by a nurse trained by an expert phsychologist, in 32 group sessions, 1 to 12 fortnightly, and 13 to 32, monthly, on top of their standard program of diet, exercise, and the other (control group), receiving the usual follow up, with regular visits every 3 months. Discussion By addressing currently unanswered questions regarding the maintenance in weight loss in obesity/overweight, upon the expected completion of participant follow-up in 2012, the IMOAP trial should document, for the first time, the benefits of a motivational intervention as a treatment tool of weight loss in a primary care setting.