Eficacia de la inducción miofascial para el tratamiento de la espasticidad en pacientes con parálisis cerebral espástica: ensayo clínico aleatorizado

¿El tratamiento mediante la inducción miofascial disminuye la espasticidad en los pacientes con Parálisis Cerebral Espástica (PCE) mientras son intervenidos con un tratamiento convencional? Objetivos: Comprobar si la inducción miofascial disminuye la espasticidad en pacientes con parálisis cerebral espástica (PCE) y así mismo prevenir las complicaciones musculoesqueléticas y aumentar el rango de movilidad articular. Metodología: Ensayo controlado clínico aleatorizado que recoge un total de 96 casos de PCE con Grado l, ll y lll de afectación según la Escala de clasificación Gross Motor Function Measure (GMFM). Se asignará de forma aleatoria y equitativamente 48 sujetos al grupo control aplicándose el tratamiento convencional y 48 sujetos al grupo experimental, donde la inducción miofascial se complementará con tratamiento convencional. Durante 3 meses se llevará a cabo el plan de intervención, 2 días a la semana en ambos grupos. Los datos serán analizados a través de las siguientes escalas: el tono muscular (Escala de Ashworth Modificada, Escala de Tardieu, Test pendular Wartenberg) funcionalidad y actividad (Gross Motor Function Classification System, Gross Motor Function Mesurement, Pediatric Evaluation of Disability Inventory), valoración neurológica (National Institute of NEurological Disordes and Stroke Scale) y la satisfacción del paciente (Questionnaire on Pain Caused by Spasticity). Estos datos serán extraidos el primer día, el último y 3 meses más tarde a modo de seguimiento. Durante el plan de intervención también se realizarán valoraciones semanales y mensuales.

The Significance of Business Exit for Future Entrepreneurial Activity

Purpose: The purpose of this paper is to analyse the impact of business exits on future dimensions of entrepreneurial activity at the macroeconomic level. Design/methodology/approach: This research uses the Global Entrepreneurship Monitor (GEM) data for 41 countries and the Generalized Method of Moments (GMM) to carry out the analysis. The paper differentiates the effect of the two components of total entrepreneurial activity, and the two motivations for it – opportunity and necessity entrepreneurship. Findings: The results presented here show a positive and significant effect of the coefficient associated with exits in all models. This means that the levels of entrepreneurial activity exceed business exits. The robustness of the models are tested, including other variables such as the fear of failure, the Gross Domestic Product, role models, entrepreneurial skills and the unemployment variables. The main hypothesis which stated that at national level business exits imply greater rates of opportunity-driven entrepreneurship is corroborated. Originality/value: One would expect that unemployment rates would imply higher levels of necessity entrepreneurship. However, results show that unemployment rates do in fact favour opportunity entrepreneurship levels. This could be due to those government policies that are aimed at promoting entrepreneurship through the capitalization of unemployment to be totally invested in a new start-up. To the best of our knowledge, this is the first panel data study to link previous exit rates to future dimensions of entrepreneurial activity. Keywords: Entrepreneurship, business exits, social values, industrial organization Paper type: Research paper

Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease

Background: The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD). Methods: In two double-blind, 52-week studies, ACCLAIM/COPD I (n = 843) and II (n = 804), patients were randomised to inhaled aclidinium 200 μg or placebo once-daily. Patients were required to have a postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity ratio of ≤70% and FEV1 <80% of the predicted value. The primary endpoint was trough FEV1 at 12 and 28 weeks. Secondary endpoints were health status measured by St George"s Respiratory Questionnaire (SGRQ) and time to first moderate or severe COPD exacerbation. Results: At 12 and 28 weeks, aclidinium improved trough FEV1 versus placebo in ACCLAIM/COPD I (by 61 and 67 mL; both p < 0.001) and ACCLAIM/COPD II (by 63 and 59 mL; both p < 0.001). More patients had a SGRQ improvement ≥4 units at 52 weeks with aclidinium versus placebo in ACCLAIM/COPD I (48.1% versus 39.5%; p = 0.025) and ACCLAIM/COPD II (39.0% versus 32.8%; p = 0.074). The time to first exacerbation was significantly delayed by aclidinium in ACCLAIM/COPD II (hazard ratio [HR] 0.7; 95% confidence interval [CI] 0.55 to 0.92; p = 0.01), but not ACCLAIM/COPD I (HR 1.0; 95% CI 0.72 to 1.33; p = 0.9). Adverse events were minor in both studies. Conclusion: Aclidinium is effective and well tolerated in patients with moderate to severe COPD. Trial registration: ClinicalTrials.gov: NCT00363896 ACCLAIM/COPD I) and NCT00358436 (ACCLAIM/COPD II).

Extending body space in immersive virtual reality: a very long arm illusion

Recent studies have shown that a fake body part can be incorporated into human body representation through synchronous multisensory stimulation on the fake and corresponding real body part- the most famous example being the Rubber Hand Illusion. However, the extent to which gross asymmetries in the fake body can be assimilated remains unknown. Participants experienced, through a head-tracked stereo head-mounted display a virtual body coincident with their real body. There were 5 conditions in a between-groups experiment, with 10 participants per condition. In all conditions there was visuo-motor congruence between the real and virtual dominant arm. In an Incongruent condition (I), where the virtual arm length was equal to the real length, there was visuo-tactile incongruence. In four Congruent conditions there was visuo-tactile congruence, but the virtual arm lengths were either equal to (C1), double (C2), triple (C3) or quadruple (C4) the real ones. Questionnaire scores and defensive withdrawal movements in response to a threat showed that the overall level of ownership was high in both C1 and I, and there was no significant difference between these conditions. Additionally, participants experienced ownership over the virtual arm up to three times the length of the real one, and less strongly at four times the length. The illusion did decline, however, with the length of the virtual arm. In the C2-C4 conditions although a measure of proprioceptive drift positively correlated with virtual arm length, there was no correlation between the drift and ownership of the virtual arm, suggesting different underlying mechanisms between ownership and drift. Overall, these findings extend and enrich previous results that multisensory and sensorimotor information can reconstruct our perception of the body shape, size and symmetry even when this is not consistent with normal body proportions.

The determinants of social spending in Spain, 1950-1980, Are dictatorships less redistributive?

[spa] La mayoría de estudios sobre el Estado del Bienestar, hasta el momento, se han centrado en países democráticos y ricos. Sin embargo, los países pobres y no democráticos han recibido mucha menos atención. Este artículo aporta nueva evidencia empírica sobre la evolución del gasto social en España y Portugal entre 1950 y 1980. A partir de ésta se ha podido analizar la relación entre dictaduras y redistribución, ya que ambos países sufrieron gobiernos no democráticos durante la mayor parte del periodo. Además del gasto social público y su clasificación por funciones, en este artículo se analiza también la forma de financiación de dicho gasto social.

Reconstruction of the Regional GDP of Portugal, 1890 – 1980

[cat] Aquest article metodològic ofereix estimacions del PIB per càpita regional de les regions portugueses, entre 1890 i 1980. Aquestes estimacions s’han obtingut seguint la metodologia proposada per (Geary and Stark, 2002) per a la industria, i considerant estimacions de producció directa per la resta de sectors.

Reconstruction of the Regional GDP of Portugal, 1890 – 1980

[cat] Aquest article metodològic ofereix estimacions del PIB per càpita regional de les regions portugueses, entre 1890 i 1980. Aquestes estimacions s’han obtingut seguint la metodologia proposada per (Geary and Stark, 2002) per a la industria, i considerant estimacions de producció directa per la resta de sectors.

The determinants of social spending in Spain, 1950-1980, Are dictatorships less redistributive?

[spa] La mayoría de estudios sobre el Estado del Bienestar, hasta el momento, se han centrado en países democráticos y ricos. Sin embargo, los países pobres y no democráticos han recibido mucha menos atención. Este artículo aporta nueva evidencia empírica sobre la evolución del gasto social en España y Portugal entre 1950 y 1980. A partir de ésta se ha podido analizar la relación entre dictaduras y redistribución, ya que ambos países sufrieron gobiernos no democráticos durante la mayor parte del periodo. Además del gasto social público y su clasificación por funciones, en este artículo se analiza también la forma de financiación de dicho gasto social.

The Role of Railways in Export-Led Growth: The Case of Uruguay, 1870-1913

The social saving literature has highlighted the indispensable role that railways played before 1914 in several Latin American export-oriented economies, such as Mexico, Brazil and Argentina. The article analyses the case of Uruguay, a country that, by 1914, had built one of the densest railway networks in Latin America. The article shows that, in contrast to what happened in other economies of the region, the resource saving effects of the Uruguayan railways during the first globalisation were tiny due to the small share that railway output accounted for within the country's gross domestic product (GDP). Three complementary reasons are suggested to explain that result, namely: the geographical structure of the country; its sectoral specialisation; and the small scale of the Uruguayan economy. Due to these three characteristics, Uruguay was unable to benefit from railways in the way that other export-oriented Latin American economies did during the first period of globalisation. This conclusion draws attention to the geographic-specific character of railway technology.

En respuesta a la ONU : ¿Es el fútbol un indicador del progreso y desarrollo en la esfera internacional?

[spa] El objetivo de este trabajo es corroborar la afirmación de la ONU de que el deporte es una herramienta poderosa para el progreso y el desarrollo. En este contexto, examinamos si el fútbol puede considerarse un indicador de desarrollo a nivel internacional. Un modelo empírico econométrico se diseña con el fin de analizar el desarrollo en términos de PIB per cápita, así como en términos del Índice de Desarrollo Humano. Se utiliza información transversal y temporal. Los resultados sugieren que la clasificación de la FIFA de selecciones nacionales puede ser utilizada para complementar nuestra comprensión del desarrollo multidimensional, en particular, en aquellos países donde la disponibilidad de información no es tan buena como los investigadores desearían.

En respuesta a la ONU : ¿Es el fútbol un indicador del progreso y desarrollo en la esfera internacional?

[spa] El objetivo de este trabajo es corroborar la afirmación de la ONU de que el deporte es una herramienta poderosa para el progreso y el desarrollo. En este contexto, examinamos si el fútbol puede considerarse un indicador de desarrollo a nivel internacional. Un modelo empírico econométrico se diseña con el fin de analizar el desarrollo en términos de PIB per cápita, así como en términos del Índice de Desarrollo Humano. Se utiliza información transversal y temporal. Los resultados sugieren que la clasificación de la FIFA de selecciones nacionales puede ser utilizada para complementar nuestra comprensión del desarrollo multidimensional, en particular, en aquellos países donde la disponibilidad de información no es tan buena como los investigadores desearían.

En respuesta a la ONU : ¿Es el fútbol un indicador del progreso y desarrollo en la esfera internacional?

[spa] El objetivo de este trabajo es corroborar la afirmación de la ONU de que el deporte es una herramienta poderosa para el progreso y el desarrollo. En este contexto, examinamos si el fútbol puede considerarse un indicador de desarrollo a nivel internacional. Un modelo empírico econométrico se diseña con el fin de analizar el desarrollo en términos de PIB per cápita, así como en términos del Índice de Desarrollo Humano. Se utiliza información transversal y temporal. Los resultados sugieren que la clasificación de la FIFA de selecciones nacionales puede ser utilizada para complementar nuestra comprensión del desarrollo multidimensional, en particular, en aquellos países donde la disponibilidad de información no es tan buena como los investigadores desearían.

Fiscal sustainability and fiscal shocks in a dollarized and oil-exporting country: Ecuador

This paper investigates the fiscal sustainability of an emerging, dollarized, oil-exporting country: Ecuador. A cointegrated VAR approach is adopted in testing, first, if the intertemporal budget constraint is satisfied in Ecuador and, second, in identifying the permanent and transitory shocks that affect a fiscal policy characterized by inertia and a heavy dependence on oil revenues. Following confirmation that the debt-GDP ratio does not place the Ecuadorian budget under any pressure, we reformulate the model and identify two forces that push the fiscal system out of equilibrium, namely, economic activity and oil revenues implemented in the government budget. We argue that Ecuador needs to recover control of its monetary policy and to promote the diversification of its economy in order that non-oil tax revenues can replace oil revenues as a pushing force. Finally, we calculate quarterly elasticities of tax revenues with respect to Ecuador’s GDP and that of eight Eurozone countries. We illustrate graphically how the Eurozone countries with low positive or high negative elasticities’ levels suffer debt problems after the crisis. This finding emphasizes the pressing need for Ecuador to strengthen the connection between its tax revenues and output, and also suggests that the convergence of these elasticities in the Eurozone might contribute to the success of an eventually future fiscal union.

Tissue distribution of retinoids in common dolphins (Delphinus delphis).

Exposure to organochlorines induces retinoid deficiency in mammals; hence, retinoids are potential biomarkers of the impact of these pollutants. Appropriate target tissues to monitor retinoids in cetaceans have not been properly identified because of a lack of information on the contribution of each tissue to total body retinoids. Therefore, we have addressed this issue by studying the contribution of the main body tissues to retinoids in 21 common dolphins obtained from incidental catches and in apparent good health and nutritive condition. Although concentrations in the liver were highest, those in blubber were also high and accounted for 43% of the total retinoid load of the compartments examined. As blubber can be obtained using non-invasive biopsy techniques, this tissue is proposed as a reliable indicator of retinoid status in cetaceans. However, blubber topographical variation in structure and composition requires standardization of sampling sites. Retinoid concentrations did not differ significantly between sexes or with body size for any of the tissues, but the lipid content of blubber strongly influenced these concentrations. Biopsies from healthy, free-ranging individuals are preferred to samples from stranded animals. Further research on the influence of factors (age, sex, reproductive condition, diet) that potentially affect retinoid levels is required to implement the use of retinoids as biomarkers of pollutant exposure in cetaceans.