egr-4, a target of EGFR signaling, is required for the formation of the brian primordial and head regeneration in planarians

During the regeneration of freshwater planarians, polarity and patterning programs play essential roles in determining whether a head or a tail regenerates at anterior or posterior-facing wounds. This decision is made very soon after amputation. The pivotal role of the Wnt/β-catenin and Hh signaling pathways in re-establishing anterior-posterior (AP) polarity has been well documented. However, the mechanisms that control the growth and differentiation of the blastema in accordance with its AP identity are less well understood. Previous studies have described a role of Smed-egfr-3, a planarian epidermal growth factor receptor, in blastema growth and differentiation. Here, we identify Smed-egr-4, a zinc-finger transcription factor belonging to the early growth response gene family, as a putative downstream target of Smed-egfr-3. Smed-egr-4 is mainly expressed in the central nervous system and its silencing inhibits anterior regeneration without affecting the regeneration of posterior regions. Single and combinatorial RNA interference to target different elements of the Wnt/β-catenin pathway, together with expression analysis of brain- and anterior-specific markers, revealed that Smed-egr-4: (1) is expressed in two phases - an early Smed-egfr-3-independent phase and a late Smed-egfr-3-dependent phase; (2) is necessary for the differentiation of the brain primordia in the early stages of regeneration; and (3) that it appears to antagonize the activity of the Wnt/β-catenin pathway to allow head regeneration. These results suggest that a conserved EGFR/egr pathway plays an important role in cell differentiation during planarian regeneration and indicate an association between early brain differentiation and the proper progression of head regeneration.

L'estructura territorial al Bisbat de Girona

Estudi sobre l'estructura socioeconòmica del Bisbat de Girona amb la finalitat de dibuixar les àrees funcionals que estructures aquest espai, i poder endegar, a la llarga una reforma dels actuals límits de l'arxiprestat

Correlating trainees' translating performance with the quality of their metacognitive self-evaluation

This paper presents a study of correlations between the performance of trainee translators, according to their teacher’s assessment, and the quality of their self-evaluation, according to their answers to metacognitive questionnaires. Two case-studies of two consecutive editions of a course in general translation from German into Spanish are dealt with. The course involved the use of post-translation metacognitive questionnaires designed to help trainees to evaluate their translating. A selection of the questionnaires (from the strongest and the weakest performances by students for each course edition) is considered. The study focuses on one item in these questionnaires that has to do with identifying translation problems and justifying their solutions. An interpretive analysis of the trainees’ answers for this questionnaire item reveals that the best-performing students were more strategically and translationally aware in self-evaluating their own translating. Our conclusions are based on considering six parameters from the analysis of the trainees’ answers, which are tentatively regarded as indicative of the quality of their self-evaluation.

Efficacy and safety of tigecycline versus levofloxacin for community-acquired pneumonia.

Abstract Background: Tigecycline, an expanded broad-spectrum glycylcycline, exhibits in vitro activity against many common pathogens associated with community-acqui red pneumonia (CAP), as well as penetration into lung tissues that suggests effectiveness in ho spitalized CAP patients. The aim of the present study was to compare the efficacy and safety of intravenous (IV) tigecycline with IV levofloxacin in hospitalized adults with CAP. Methods: In this prospective, double-blin d, non-inferiority phase 3 trial, eligible patients with a clinical diagnosis of CAP supported by radiographic evidence were stratified by Fine Pneumonia Severity Index and randomized to tigecycline or levofloxacin for 7-14 days of therapy. Co-primary efficacy endpoints were clinical response in the clinically evaluable (CE) and clinical modified intent- to-treat (c-mITT) populations at te st-of-cure (Day 10-21 post-therapy). Results: Of the 428 patients who received at least on e dose of study drug, 79% had CAP of mild-moderate severity according to their Fine score. Clinical cure rates for the CE population were 88.9% for tigecycline and 85.3% for levofloxac in. Corresponding c-mITT population rates were 83.7% and 81.5%, respectively. Eradication rates for Streptococcus pneumoniae were 92% for tigecycline and 89% for levofloxac in. Nausea, vomiting, and diarrhoea were the most frequently reported adverse events. Rates of premature disc continuation of study drug or study withdrawal because of any adverse event were similar for both study drugs. Conclusion: These findings suggest that IV tigecycline is non-inferior to IV levofloxacin and is generally well-tolerated in the treatment of hospitalized adults with CAP.

Simulació d'activitats professionals a l'oficina de farmàcia des de l'assignatura Gestió i Planificació

L’assignatura Gestió i Planificació és una assignatura obligatòria en la menció Farmàcia Assistencial i Anàlisis Clíniques del Pla d’estudis del Grau de Farmàcia de l’any 2009 i el seu objectiu és aconseguir que els alumnes obtinguin els coneixements que els permetin assolir la capacitat de direcció i gestió necessàries en professionals sanitaris, que intentaran aconseguir la màxima rendibilitat de les oficines de farmàcia i serveis farmacèutics on desenvoluparan la seva activitat laboral, una rendibilitat encara més necessària en un temps marcat per la crisi i les retallades en sanitat. Es tracta d‘una assignatura que com totes les impartides per la Unitat d’Història de la Farmàcia, Legislació i Gestió Farmacèutiques és diferent de les altres que formen part de la carrera, en situar-se en un àmbit que interrelaciona el món del medicament i la farmàcia amb les ciències socials.

Residència universitària al Campus de Ciències de la Salut de Bellvitge

Award-winning

Bibliografia d'Enric Mirambell i Belloc (1947- )

Se'ns presenta una oportunitat ulllca d'aplegar en aquestes pagllles I'extensa producció escrita del Sr. Mirambell i Belloc. Des deis seus inicis professionals fins a I'actualitat com a cronista de la ciutat de Girona, ha composat pagines consagrades a temes d'actualitat social i d'ambit cultural, així com d'ambit historic i educatiu. Des d'articles de premsa fins a estudis monografics dedicats a I'ensenyament, la impremta, la Biblioteca Pública de Girona, etc.; tots ells d'un elevat valor cultural i d'una qualitat innegable. Així doncs, disposat en vuit blocs: lIibres, col'laboracions en obres col'lectives, articles en publicacions periodiques, miscel·lanies i homenatges, conferencies, comunicacions i ponencies, fultets, prolegs, epílegs i estudis introductoris i obres menors, s'ha volgut copsar tota aquesta riquesa ,

Safety of intramuscular influenza vaccine in patients receiving oral anticoagulation therapy: a single blinded multi-centre randomized controlled clinical trial

Influenza vaccines are recommended for administration by the intramuscular route. However, many physicians use the subcutaneous route for patients receiving an oral anticoagulant because this route is thought to induce fewer hemorrhagic side effects. Our aim is to assess the safety of intramuscular administration of influenza vaccine in patients on oral anticoagulation therapy. Methods: Design: Randomised, controlled, single blinded, multi-centre clinical trial. Setting: 4 primary care practices in Barcelona, Spain. Participants: 229 patients on oral anticoagulation therapy eligible for influenza vaccine during the 20032004 season. Interventions: intramuscular administration of influença vaccine in the experimental group (129 patients) compared to subcutaneous administration in the control group (100 patients). Primary outcome: change in the circumference of the arm at the site of injection at 24 hours. Secondary outcomes: appearance of local reactions and pain at 24 hours and at 10 days; change in INR (International Normalized Ratio) at 24 hours and at 10 days. Analysis was by intention to treat using the 95% confidence intervals of the proportions or mean differences. Results: Baseline variables in the two groups were similar. No major side effects or major haemorrhage during the follow-up period were reported. No significant differences were observed in the primary outcome between the two groups. The appearance of local adverse reactions was more frequent in the subcutaneous administration group (37,4% vs. 17,4%, 95% confidence interval of the difference 8,2% to 31,8%). Conclusion: This study shows that the intramuscular administration route of influenza vaccine in patients on anticoagulant therapy does not have more side effects than the subcutaneous administration route

La actividad de los medios tradicionales en las redes Google Plus y Linkedin

L'era 2.0 ha arribat als nostres dies i amb això, les xarxes socials ja formen part de la vida diària de molts habitants del planeta. Cada dia, milions de persones es connecten i interactuen a través d'elles amb la finalitat d'entretenir-se i informar-se. Tot això ha fet que molts mitjans de comunicació tradicionals hagin hagut de renovar-se per oferir als usuaris un servei que anys enrere ni es plantejaven i que en alguns casos els ha agafat desprevinguts. Per això, el present Treball Final de Carrera analitza l'activitat dels mitjans El País, El Mundo, La Vanguardia i El Periódico de Catalunya a les xarxes socials Google+ i LinkedIn. La popularitat, la interactivitat i la influència seran factors determinants per veure quin és el mitjà que realitza un millor ús d'aquestes xarxes socials, minoritàries, que guanyen terreny en el dia a dia.