'Making Science Understandable'. Divulgació científica i mediació editorial: el cas de The Wisdom of the Body de Walter B. Cannon (1871-1945)

The present paper aims at an historical reconstruction, in the framework of the publishing industry in the years between the two World Wars, of the role played by the publisher William W. Norton in the genesis, published in 1932, and new edition in 1938, of Walter B. Cannon"s book The Wisdom of the Body. With the analysis of this case study, we aimed at contributing to the current criticism of the «dominant view», which tries, in an uncritical manner, that scientific popularization follows an ineluctable, continuous and linear evolution.

Generalized synchronization in directionally coupled systems with identical individual dynamics

A simple chaotic flow is presented, which when driven by an identical copy of itself, for certain initial conditions, is able to display generalized synchronization instead of identical synchronization. Being that the drive and the response are observed in exactly the same coordinate system, generalized synchronization is demonstrated by means of the auxiliary system approach and by the conditional Lyapunov spectrum. This is interpreted in terms of changes in the structure of the system stationary points, caused by the coupling, which modify its global behavior.

SiMR: A simulator for learning computer architecture

This paper presents SiMR, a simulator of the Rudimentary Machine designed to be used in a first course of computer architecture of Software Engineering and Computer Engineering programmes. The Rudimentary Machine contains all the basic elements in a RISC computer, and SiMR allows editing, assembling and executing programmes for this processor. SiMR is used at the Universitat Oberta de Catalunya as one of the most important resources in the Virtual Computing Architecture and Organisation Laboratory, since students work at home with the simulator and reports containing their work are automatically generated to be evaluated by lecturers. The results obtained from a survey show that most of the students consider SiMR as a highly necessary or even an indispensable resource to learn the basic concepts about computer architecture.

Apertium Advanced Web Interface : A first step towards interactivity and language tools convergence

This documents sums up a projectaimed at building a new web interfaceto the Apertium machine translationplatform, including pre-editing andpost-editing environments. It containsa description of the accomplished workon this project, as well as an overviewof possible evolutions.

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains.

Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic reticulum (ER) to LDs in response to fatty acids to characterize the initial steps of LD formation occurring in lipid-starved cells. Initially, arriving lipids are rapidly packed in LDs that are resistant to starvation (pre-LDs). Pre-LDs are restricted ER microdomains with a stable core of neutral lipids. Subsequently, a first round of"emerging" LDs is nucleated, providing additional lipid storage capacity. Finally, in proportion to lipid concentration, new rounds of LDs progressively assemble. Confocal microscopy and electron tomography suggest that emerging LDs are nucleated in a limited number of ER microdomains after a synchronized stepwise process of protein gathering, lipid packaging, and recognition by Plin3 and Plin2. A comparative analysis demonstrates that the acyl-CoA synthetase 3 is recruited early to the assembly sites, where it is required for efficient LD nucleation and lipid storage.

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains.

Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic reticulum (ER) to LDs in response to fatty acids to characterize the initial steps of LD formation occurring in lipid-starved cells. Initially, arriving lipids are rapidly packed in LDs that are resistant to starvation (pre-LDs). Pre-LDs are restricted ER microdomains with a stable core of neutral lipids. Subsequently, a first round of"emerging" LDs is nucleated, providing additional lipid storage capacity. Finally, in proportion to lipid concentration, new rounds of LDs progressively assemble. Confocal microscopy and electron tomography suggest that emerging LDs are nucleated in a limited number of ER microdomains after a synchronized stepwise process of protein gathering, lipid packaging, and recognition by Plin3 and Plin2. A comparative analysis demonstrates that the acyl-CoA synthetase 3 is recruited early to the assembly sites, where it is required for efficient LD nucleation and lipid storage.

Llibres d'artista i publicacions per tot arreu

Un recorregut per la historia de les edicions d'artista a Catalunya a través de la cultura visual i l'art contemporani. Amb l'edició independent i la xarxa digital com dues eines fonamentals tan pels artistes -pels beneficis que l'edició pot proporcionar a la seva visibilitat i l'evolució professional- com pels diferents agents -veuen en ella l'oportunitat de generar nous formats de relació amb el públic- que tenen la voluntat de treballar amb i per aquest subsector de l'últim art contemporani. Un àmbit que avui gaudeix d'una situació creativa i productiva molt interessant i fructífera.

Validation study of the Spanish Version of the Work-Family Conflict Questionnaire (CCTF)

In this study, a brief Work-Family Conflict (WFC) Questionnaire in the Spanish language is proposed that takes into account the two directions commonly reported in the literature: work interference with family (WIF), and family interference with work (FIW). The results obtained through exploratory factor analyses (EFA) and confirmatory factor analyses (CFA) with two independent samples, carried out for women and men, showed acceptable validity and reliability. A copy of the instrument in Spanish language is provided, together with the Amos 4 syntax to perform the factor invariance analysis for women and men. The suggested Work-Family Conflict Questionnaire (in Spanish, abbreviated as CCTF) may be useful in studies performed in the work setting, considering the special relevance of the concept in this line of research.

Analysis of meiotic recombination in 22q11.2, a region that frequently undergoes deletions and duplications

Background: The 22q11.2 deletion syndrome is the most frequent genomic disorder with an estimated frequency of 1/4000 live births. The majority of patients (90%) have the same deletion of 3 Mb (Typically Deleted Region, TDR) that results from aberrant recombination at meiosis between region specific low-copy repeats (LCRs). Methods: As a first step towards the characterization of recombination rates and breakpoints within the 22q11.2 region we have constructed a high resolution recombination breakpoint map based on pedigree analysis and a population-based historical recombination map based on LD analysis. Results: Our pedigree map allows the location of recombination breakpoints with a high resolution (potential recombination hotspots), and this approach has led to the identification of 5 breakpoint segments of 50 kb or less (8.6 kb the smallest), that coincide with historical hotspots. It has been suggested that aberrant recombination leading to deletion (and duplication) is caused by low rates of Allelic Homologous Recombination (AHR) within the affected region. However, recombination rate estimates for 22q11.2 region show that neither average recombination rates in the 22q11.2 region or within LCR22-2 (the LCR implicated in most deletions and duplications), are significantly below chromosome 22 averages. Furthermore, LCR22-2, the repeat most frequently implicated in rearrangements, is also the LCR22 with the highest levels of AHR. In addition, we find recombination events in the 22q11.2 region to cluster within families. Within this context, the same chromosome recombines twice in one family; first by AHR and in the next generation by NAHR resulting in an individual affected with the del22q11.2 syndrome. Conclusion: We show in the context of a first high resolution pedigree map of the 22q11.2 region that NAHR within LCR22 leading to duplications and deletions cannot be explained exclusively under a hypothesis of low AHR rates. In addition, we find that AHR recombination events cluster within families. If normal and aberrant recombination are mechanistically related, the fact that LCR22s undergo frequent AHR and that we find familial differences in recombination rates within the 22q11.2 region would have obvious health-related implications.

La profesionalización de la enfermería en Lleida a partir de las Hijas de la Caridad

El objetivo del estudio es describir el proceso de profesionalización de la enfermería en Lleida a partir de la llegada de las Hijas de la Caridad de San Vicente de Paúl en el Hospital de Santa María. MATERIAL Y MÉTODO: Estudio histórico mediante técnica de observación documental y análisis de documentos legislativos. Los documentos utilizados son: copia de la escritura del establecimiento de las Hijas de la Caridad en el Hospital de Santa María (1792) y las Constituciones para el gobierno del Santo Hospital General de la Ciudad de Lérida (1797). RESULTADOS: En la copia de la escritura se establece que las hermanas se encargarán del régimen y cuidados de los enfermos según las reglas de su instituto; y que tanto el gobierno y dirección interior y exterior de ellas dependerá de la Congregación. En las Constituciones del 1797 se acredita que han resultado beneficiosas tanto para la organización del hospital como para la atención sanitaria. Ponen énfasis en posibles divulgaciones negativas con respecto a ellas. CONCLUSIONES Y DISCUSIÓN: El establecimiento de las Hijas de la Caridad mejoró la atención sanitaria de los enfermos y la salubridad del centro. La contraprestación económica nos ayuda para que podamos hablar de profesionalización de enfermería.

Dos raros incunables en lengua catalana

En este trabajo se ofrece una panorámica de los estimables fondos incunables de La Casa del Libro (San Juan, Puerto Rico) y se analizan los contenidos de dos impresos barceloneses en lengua catalana de temática religiosa: Vida e transit de Sanct Jheronim (1493) y Gamaliel (c. 1493). El examen de ambos ejemplares confirma su importancia, en especial del segimdo, pues se trata de un ejemplar único en el mundo. También se apuntan diversos aspectos de su dilatada trayectoria y se ofrece una hipótesis sobre su origen.

Association study of lipoprotein(a) genetic markers, traditional risk factors, and coronary heart disease in HIV-1-infected patients.

Objectives: General population studies have shown associations between copy number variation (CNV) of the LPA gene Kringle-IV type-2 (KIV-2) coding region, single-nucleotide polymorphism (SNP) rs6415084 in LPA and coronary heart disease (CHD). Because risk factors for HIV-infected patients may differ from the general population, we aimed to assess whether these potential associations also occur in HIV-infected patients. Methods: A unicenter, retrospective, case-control (1:3) study. Eighteen HIV-patients with confirmed diagnosis of acute myocardial infarction (AMI) were adjusted for age, gender, and time since HIV diagnosis to 54 HIV-patients without CHD. After gDNA extraction from frozen blood, both CNV and SNP genotyping were performed using real-time quantitative PCR. All genetic and non-genetic variables for AMI were assessed in a logistic regression analysis. Results: Our results did not confirm any association in terms of lipoprotein(a) LPA structural genetic variants when comparing KIV-2 CNV (p = 0.67) and SNP genotypes (p = 0.44) between AMI cases and controls. However, traditional risk factors such as diabetes mellitus, hypertension, and CD4(+) T cell count showed association (p < 0.05) with CHD. Conclusion: Although significant associations of AMI with diabetes, hypertension and CD4(+) T cell count in HIV-patients were found, this study could not confirm the feasibility neither of KIV-2 CNV nor rs6415084 in LPA as genetic markers of CHD in HIV-infected patients.Highlights:● Individuals with HIV infection are at higher risk of coronary heart disease (CHD) than the non-infected population.● Our results showed no evidence of LPA structural genetic variants associated with CHD in HIV-1-infected patients.● Associations were found between diabetes mellitus, arterial hypertension, CD4(+) T cell count, and CHD.● The clinical usefulness of these biomarkers to predict CHD in HIV-1-infected population remains unproven.● Further studies are needed to assess the contribution of common genetic variations to CHD in HIV-infected individuals.

Aplicatiu web per a la confecció de plans de seguretat i salut en obres de construcció

Web application for redact health and safety plans in works. The application includes a manager of users, a manager for payment and the process for doing plans. It defines two kind of users: freemium and payment users. The firsts can do two plans in a year and the seconds doesn't have this limitation and besides they have editing tools.

Use and availability of scholarly journals in Catalan academic libraries

This paper presents the results of a survey of academics affiliated to the universities that are members of the Consortium of Academic Libraries of Catalonia (CBUC) and an analysis of the availability in the libraries of these universities of the references cited in a sample of articles published by these academics. The results reflect the major importance that researchers assign to scholarly journals as the main source of scientific information. Most state that they use electronic journals either exclusively or in any case more than print journals, a preference that is higher among younger scholars. With regard to frequency of reading, four out of ten researchers state that they read journals virtually every day, while nine out of ten report that they do so at least once a week. Scholars claim that the obstacles they face when trying to download an article are related to the lack of subscriptions. However, the availability study showed that most of the articles cited in their publications are available at least at one of the CBUC libraries. Though most researchers keep a copy of the articles they consult, just over a third of them use some kind of reference management software.

'Making Science Understandable'. Divulgació científica i mediació editorial: el cas de The Wisdom of the Body de Walter B. Cannon (1871-1945)

The present paper aims at an historical reconstruction, in the framework of the publishing industry in the years between the two World Wars, of the role played by the publisher William W. Norton in the genesis, published in 1932, and new edition in 1938, of Walter B. Cannon"s book The Wisdom of the Body. With the analysis of this case study, we aimed at contributing to the current criticism of the «dominant view», which tries, in an uncritical manner, that scientific popularization follows an ineluctable, continuous and linear evolution.