Palmeres que ensumen diamants

Totes les plantes estan adaptades a viure en unes condicions ambientals concretes i en un determinat tipus del sòl. La relació que s'estableix entre la vegetació i la composició mineralògica del sòl ha fet que els geòlegs, quan busquen jaciments, es fixin, entre moltes altres dades, en les plantes que hi creixen. Stephen E. Haggerty i els seus col·laboradors, de la Universitat Internacional de Florida, als EUA, han descobert un tipus de palmera que creix únicament en indrets rics en diamants, en zones tropicals humides. La seva proposta, que recull la revista Economic Geology, és utilitzar aquesta correlació com un indicador per buscar nous jaciments, la qual cosa facilitaria la tasca i evitaria malmetre el medi ambient en prospeccions infructuoses.

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines

We have synthesized a series of dimers of (+)-(7R,11R)-huprine Y and evaluated their activity against Trypanosoma brucei, Plasmodium falciparum, rat myoblast L6 cells and human acetylcholinesterase (hAChE), and their brain permeability. Most dimers have more potent and selective trypanocidal activity than huprine Y and are brain permeable, but they are devoid of antimalarial activity and remain active against hAChE. Lead optimization will focus on identifying compounds with a more favourable trypanocidal/anticholinesterase activity ratio.

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines

We have synthesized a series of dimers of (+)-(7R,11R)-huprine Y and evaluated their activity against Trypanosoma brucei, Plasmodium falciparum, rat myoblast L6 cells and human acetylcholinesterase (hAChE), and their brain permeability. Most dimers have more potent and selective trypanocidal activity than huprine Y and are brain permeable, but they are devoid of antimalarial activity and remain active against hAChE. Lead optimization will focus on identifying compounds with a more favourable trypanocidal/anticholinesterase activity ratio.