Amazon.es : incògnites i expectatives. Amb Enric Faura i Pep Torn

Debat a l'Internauta, el primer programa de ràdio del país sobre la xarxa, una col·laboració entre la UOC i Vilaweb. Fa menys d'una setmana que es va confirmar la notícia: la plataforma de comerç electrònic més potent de la xarxa, Amazon, va obrir dimecres de la setmana passada la filial ibèrica. Amazon és actualment el portal de venda en línia més important i divers, amb un catàleg de milions de llibres impresos i electrònics, a més d'un gavadal de productes com ara compactes, DVD, jocs, aparells d'electrònica de consum i, fins i tot, roba, alimentació i mobiliari. De moment, Amazon.es ha aterrat a casa nostra amb una oferta de productes físics, entre els quals hi ha cinquanta mil llibres impresos en català, però obre tantes oportunitats com interrogants. Com afectarà les llibreries convencionals? Tindran mercat ara plataformes de llibre digital més modestes? Estimularà el negoci del llibre electrònic? Facilitarà l'autoedició de llibres? Farà créixer el nombre de lectors en català? En parlem amb Enric Faura, de la plataforma Edi.cat, i amb l'expert Pep Torn, director de l'àrea de Biblioteca i Recursos Documentals de la UOC.

Safety of intramuscular influenza vaccine in patients receiving oral anticoagulation therapy: a single blinded multi-centre randomized controlled clinical trial

Influenza vaccines are recommended for administration by the intramuscular route. However, many physicians use the subcutaneous route for patients receiving an oral anticoagulant because this route is thought to induce fewer hemorrhagic side effects. Our aim is to assess the safety of intramuscular administration of influenza vaccine in patients on oral anticoagulation therapy. Methods: Design: Randomised, controlled, single blinded, multi-centre clinical trial. Setting: 4 primary care practices in Barcelona, Spain. Participants: 229 patients on oral anticoagulation therapy eligible for influenza vaccine during the 20032004 season. Interventions: intramuscular administration of influença vaccine in the experimental group (129 patients) compared to subcutaneous administration in the control group (100 patients). Primary outcome: change in the circumference of the arm at the site of injection at 24 hours. Secondary outcomes: appearance of local reactions and pain at 24 hours and at 10 days; change in INR (International Normalized Ratio) at 24 hours and at 10 days. Analysis was by intention to treat using the 95% confidence intervals of the proportions or mean differences. Results: Baseline variables in the two groups were similar. No major side effects or major haemorrhage during the follow-up period were reported. No significant differences were observed in the primary outcome between the two groups. The appearance of local adverse reactions was more frequent in the subcutaneous administration group (37,4% vs. 17,4%, 95% confidence interval of the difference 8,2% to 31,8%). Conclusion: This study shows that the intramuscular administration route of influenza vaccine in patients on anticoagulant therapy does not have more side effects than the subcutaneous administration route

Recent advances in lamellarin alkaloids: isolation, synthesis and activity

Lamellarins are a large family of marine alkaloids with potential anticancer activity that have been isolated from diverse marine organisms, mainly ascidians and sponges. All lamellarins feature a 3,4-diarylpyrrole system. Pentacyclic lamellarins, whose polyheterocyclic system has a pyrrole core, are the most active compounds. Some of these alkaloids are potently cytotoxic to various tumor cell lines. To date, Lam-D and Lam-H have been identified as lead compounds for the inhibition of topoisomerase I and HIV-1 integrase, respectively nuclear enzymes which are over-expressed in deregulation disorders. Moreover,these compounds have been reported for their efficacy in treatment of multi-drug resistant (MDR) tumors cells without mediated drug efflux, as well as their immunomodulatory activity and selectivity towards melanoma cell lines. This article is an overview of recent literature on lamellarins, encompassing their isolation, recent synthetic strategies for their total synthesis, the preparation of their analogs, studies on their mechanisms of action, and their structure-activity relationships (SAR).

Rapid improvement of canine cognitive dysfunction with immunotherapy designed for Alzheimer's disease

Immunotherapy against amyloid-β(Aβ) may improve rodent cognitive function by reducing amyloid neuropathology and is being validated in clinical trials with positive preliminary results. However, for a complete understanding of the direct and long-term immunization responses in the aged patient, and also to avoid significant side effects, several key aspects remain to be clarified. Thus, to investigate brain Aβ clearance and Th2 responses in the elderly, and the reverse inflammatory events not found in the immunized rodent, better Alzheimer"s disease (AD) models are required. In the aged familiar canine with a Cognitive Dysfunction Syndrome (CDS) we describe the rapid effectiveness and the full safety profile of a new active vaccine candidate for human AD prevention and treatment. In these aged animals, besidesa weak immune system, the antibody response activated a coordinated central and peripheral Aβ clearance, that rapidly improved their cognitive function in absence of any side effects. Our results also confirm the interest to use familiar dogs to develop innovative and reliable therapies for AD.

Provision of supplementary materials in Library and Information Science scholarly journals

Purpose- This study seeks to analyse the policies of library and information science (LIS) journals regarding the publication of supplementary materials, the number of journals and articles that include this feature, the kind of supplementary materials published with regard to their function in the article, the formats employed and the access provided to readers. Design/methodology/approach- The study analysed the instructions for authors of LIS journals indexed in the ISI Journal Citation Reports, as well as the supplementary materials attached to the articles published in their 2011 online volumes. Findings- Large publishers are more likely to have a policy regarding the publication of supplementary materials, and policies are usually homogeneous across all the journals of a given publisher. Most policies state the acceptance of supplementary materials, and even journals without a policy also publish supplementary materials. The majority of supplementary materials provided in LIS articles are extended methodological explanations and additional results in the form of textual information in PDF or Word files. Some toll-access journals provide open access to any reader to these files. Originality/value- This study provides new insights into the characteristics of supplementary materials in LIS journals. The results may be used by journal publishers to establish a policy on the publication of supplementary materials and, more broadly, to develop data sharing initiatives in academic settings.

Gene flow and gene flux shape evolutionary patterns of variation in Drosophila subobscura

Gene flow (defined as allele exchange between populations) and gene flux (defined as allele exchange during meiosis in heterokaryotypic females) are important factors decreasing genetic differentiation between populations and inversions. Many chromosomal inversions are under strong selection and their role in recombination reduction enhances the maintenance of their genetic distinctness. Here we analyze levels and patterns of nucleotide diversity, selection and demographic history, using 37 individuals of Drosophila subobscura from Mount Parnes (Greece) and Barcelona (Spain). Our sampling focused on two frequent O-chromosome arrangements that differ by two overlapping inversions (OST and O3+4), which are differentially adapted to the environment as observed by their opposing latitudinal clines in inversion frequencies. The six analyzed genes (Pif1A, Abi, Sqd, Yrt, Atpa and Fmr1) were selected for their location across the O-chromosome and their implication in thermal adaptation. Despite the extensive gene flux detected outside the inverted region, significant genetic differentiation between both arrangements was found inside it. However, high levels of gene flow were detected for all six genes when comparing the same arrangement among populations. These results suggest that the adaptive value of inversions is maintained, regardless of the lack of genetic differentiation within arrangements from different populations, and thus favors the Local Adaptation hypothesis over the Coadapted Genome hypothesis as the basis of the selection acting on inversions in these populations.

Disruption of embryonic blood-CSF barrier in chick embryos reveals the actual importance of this barrier to control E-CSF composition and homeostasis in early brain development

In vertebrates, early brain development takes place at the expanded anterior end of the neural tube. After closure of the anterior neuropore, the brain wall forms a physiologically sealed cavity that encloses embryonic cerebrospinal fluid (E-CSF), a complex and protein-rich fluid that is initially composed of trapped amniotic fluid. E-CSF has several crucial roles in brain anlagen development. Recently, we reported the presence of transient blood-CSF barrier located in the brain stem lateral to the ventral midline, at the mesencephalon and prosencephalon level, in chick and rat embryos by transporting proteins, water, ions and glucose in a selective manner via transcellular routes. To test the actual relevance of the control of E-CSF composition and homeostasis on early brain development by this embryonic blood-CSF barrier, we block the activity of this barrier by treating the embryos with 6-aminonicotinamide gliotoxin (6-AN). We demonstrate that 6-AN treatment in chick embryos blocks protein transport across the embryonic blood-CSF barrier, and that the disruption of the barrier properties is due to the cease transcellular caveolae transport, as detected by CAV-1 expression cease. We also show that the lack of protein transport across the embryonic blood-CSF barrier influences neuroepithelial cell survival, proliferation and neurogenesis, as monitored by neurepithelial progenitor cells survival, proliferation and neurogenesis. The blockage of embryonic blood-CSF transport also disrupts water influx to the E-CSF, as revealed by an abnormal increase in brain anlagen volume. These experiments contribute to delineate the actual extent of this blood-CSF embryonic barrier controlling E-CSF composition and homeostasis and the actual important of this control for early brain development, as well as to elucidate the mechanism by which proteins and water are transported thought transcellular routes across the neuroectoderm, reinforcing the crucial role of E-CSF for brain development.

La ciutat de les dames i Terra d’elles: dues utopies feministes en catalÃ

Elizabeth Russell sosté que les utopies escrites per dones són més transgressores «perquè desconstrueixen el concepte de perfecció» (2007: 21). En aquesta línia de crítica social i necessitat de reformes, quant al gènere femení, neixen, amb cinc segles de diferència, les dues obres estudiades aquí, Le livre de la cité des dames (1405), de Christine de Pisan, i Herland (1915), de Charlotte Perkins Gilman. Amb notables excepcions com La mística de la feminitat (1965), de Betty Friedan, i El segon sexe (1968), de Simone de Beauvoir, a casa nostra els discursos androcèntrics es ben cuidaren de negar l’entrada d’aires subversius que, per raons òbvies, poguessin esverar aquell àngel de la llar amansit i silenciat, per dir-ho a la manera woolfiana. Charlotte Perkins Gilman arribà per primera vegada a Catalunya i a la península ibèrica el 1982 amb la traducció al català de Montserrat Abelló per a l’editorial La Sal d’El paper de paret groc. En els mateixos anys vuitanta i per a la mateixa editorial Helena Valentí traduí al castellà El país de ellas (1987), obra que el 2002 traslladà al català Jordi Vidal Tubau en una edició a cura d’Eulàlia Lledó que porta per títol Terra d’elles. Poc després, el 1990, La ciutat de les dames, de Christine de Pisan, es pogué llegir en llengua catalana amb una edició i traducció de Mercè Otero per a la col·lecció «Espai de Dones» d’Edicions de l’Eixample. Aquest article presenta la recepció a Catalunya de dos clàssics del gènere de les utopies feministes, La ciutat de les dames (1990), de Christine de Pisan, i Terra d’elles (2002), de Charlotte Perkins Gilman, amb notes sobre la seva difusió al castellà i al gallec.

Maria Aurèlia Capmany, feminisme i traducció

Novel·lista, assagista, política, activista cultural, dona de teatre i traductora de més de trenta obres, Maria Aurèlia Capmany és autora d’una obra extensa i clarament ideològica, en què les reivindicacions feministes ocupen una gran part. Virginia Woolf i Simone de Beauvoir són les seves principals fonts teòriques i vitals. Encara que, per diverses circumstàncies, no les tradueix mai, es converteix en la seva mitjancera cultural i ideològica a casa nostra: proposant-ne traduccions a algunes editorials, escrivint-ne pròlegs, imitant-les, adaptant-ne conceptes o imatges, etc. Marguerite Duras, de qui traslladà Un dic contra el Pacífic (1965), és també una de les seves mares literàries. Aquest treball intenta ser una aproximació al feminisme de Capmany i a la seva repercussió en el camp de la traductologia.

Carme Serrallonga, el plaer de traduir

Carme Serrallonga (Barcelona, 1909-1997) començà a traduir als anys seixanta, en moments de represa de consciència ideològica i literària. Bona coneixedora de diversos idiomes, especialment l’alemany, l’anglès, el francès i l’italià, girà al català unes vint obres del teatre universal dels grans autors. Serrallonga explicava que havia començat a aprendre alemany per poder conèixer a fons l’obra de Brecht, del qual el 1966 traduí La bona persona de Sezuan, a proposta de Ricard Salvat, i cinc obres més. De l’alemany també portà al català autors com Georg Büchner, Heinrich Böll, Friedrich Dürrenmatt, Peter Handke, György Lukács, Goethe, Mozart o Alfred Döblin. A més de l’alta literatura alemanya, Serrallonga féu petites incursions en la literatura anglesa i nord-americana, la italiana i, fins i tot, la sud-africana. El 1983 l’editorial La Galera li encarregà la traducció d’En Jim Botó i en Lluc el maquinista de Michael Ende. En sis anys traduí més de trenta títols de literatura infantil. Ja jubilada, a vuitanta-quatre anys, es posà a estudiar rus pel plaer de poder llegir Anna Akhmàtova i Txèkhov en la seva llengua originària. Abans de morir, treballava en la traducció d’un llibre de poemes de l’autora russa.

Author Rights vs Self-Archiving in Spanish Scientific Journals

The paper analyzes publishers" copyright policies and self-archiving conditions of Spanish scientific journals. Data are extracted from the directory DULCINEA that contains information of 1318 Spanish journals, of which 775 (61%) allow some form of self-archiving to be about 60% of the post-print version and allowing them 87% of the deposit of the version of record. In 72% of journals the deposit can be performed immediately after publication and in 16% after article acceptance. 72% of the journals are freely available without charge to the user this figure raises up to 86% if free access after an embargo is considered. Only 18% of the journals use Creative Commons licenses. The adoption of different open access journals model in Spain is favorable, however there is still a high percentage of journals (39%) that do not provide any information about authors and publishers rights and that difficult or inhibits reuse of published articles.

Drug abuse, brain calcification and glutamate-induced neurodegeneration

Positive and negative reinforcing systems are part of the mechanism of drug dependence. Drugs with abuse potential may change the manner of response to negative emotional stimuli, activate positive emotional reactions and possess primary reinforcing properties. Catecholaminergic and peptidergic processes are of importance in these mechanisms. Current research needs to understand the types of adaptations that underlie the particularly long-lived aspects of addiction. Presently, glutamate is candidate to play a role in the enduring effects of drugs of abuse. For example, it participates in the chronic pathological changes of corticostriatal terminals produced by methamphetamine. At the synaptic level, a link between over-activation of glutamate receptors, [C(a2+)](i) increase and neuronal damage has been clearly established leading to neurodegeneration. Thus, neurodegeneration can start after an acute over-stimulation whose immediate effects depend on a diversity of calcium-activated mechanisms. If sufficient, the initial insult results in calcification and activation of a chronic on-going process with a progressive loss of neurons. At present, long-term effects of drug dependence underlie an excitotoxicity process linked to a polysynaptic pathway that dynamically regulates synaptic glutamate. Retaliatory mechanisms include energy capability of the neurons, inhibitory systems and cytoplasmic calcium precipitation as part of the neuron-glia interactions. This paper presents an integrated view of these molecular and cellular mechanisms to help understand their relationship and interdependence in a chronic pathological process that suggest new targets for therapeutic intervention.

Problemes en l'edició de textos de l'edat moderna

Reflexions sobre l'edició de textos catalans de l'edat moderna

Scientific journals in Brazil and Spain: Alternative publishing models

This paper describes high-quality journals in Brazil and Spain, with an emphasis on the distribution models used. It presents the general characteristics (age, type of publisher, and theme) and analyzes the distribution model by studying the type of format (print or digital), the type of access (open access or subscription), and the technology platform used. The 549 journals analyzed (249 in Brazil and 300 in Spain) are included in the 2011 Web of Science (WoS) and Scopus databases. Data on each journal were collected directly from their websites between March and October 2012. Brazil has a fully open access distribution model (97%) in which few journals require payment by authors thanks to cultural, financial, operational, and technological support provided by public agencies. In Spain, open access journals account for 55% of the total and have also received support from public agencies, although to a lesser extent. These results show that there are systems support of open access in scientific journals other than the"author pays" model advocated by the Finch report for the United Kingdom.

$E_{1}$-Formality of complex algebraic varieties

Let $X$ be a smooth complex algebraic variety. Morgan showed that the rational homotopy type of $X$ is a formal consequence of the differential graded algebra defined by the first term $E_{1}(X,W)$ of its weight spectral sequence. In the present work, we generalize this result to arbitrary nilpotent complex algebraic varieties (possibly singular and/or non-compact) and to algebraic morphisms between them. In particular, our results generalize the formality theorem of Deligne, Griffiths, Morgan and Sullivan for morphisms of compact Kähler varieties, filling a gap in Morgan"s theory concerning functoriality over the rationals. As an application, we study the Hopf invariant of certain algebraic morphisms using intersection theory.