El retorn a la vida. Treballs de restauració i estudi a dues peces del Museu Egipci de Barcelona

Es tracta de tres rotlles de papir, dos d’ells d’apariéncia iguals i el tercer ben diferent amb grandària i estat de conservació.Els dos primers de tamany i patologies semblants, enrotllats amb l’escriptura per la part interior,per la qual cosa en un principi no es podia identificar, semblaven ser el mateix rotlle partit pel elmig, el tercer, si be aparentava ser igual que els altres, venia plegat per un costat i més deteriorat, al desplegar-los resultaren ser tots tres la continuïtat del mateix text.

Macroautophagic process was differentially modulated by long-term moderate exercise in rat brain and peripheral tissues

The autophagic process is a lysosomal degradation pathway, which is activated during stress conditions, such as starvation or exercise. Regular exercise has beneficial effects on human health, including neuroprotection. However, the cellular mechanisms underlying these effects are incompletely understood. Endurance and a single bout of exercise induce autophagy not only in brain but also in peripheral tissues. However, little is known whether autophagy could be modulated in brain and peripheral tissues by long-term moderate exercise. Here, we examined the effects on macroautophagy process of long-term moderate treadmill training (36 weeks) in adult rats both in brain (hippocampus and cerebral cortex) and peripheral tissues (skeletal muscle, liver and heart). We assessed mTOR activation and the autophagic proteins Beclin 1, p62, LC3B (LC3B-II/LC3B-I ratio) and the lysosomal protein LAMP1, as well as the ubiquitinated proteins. Our results showed in the cortex of exercised rats an inactivation of mTOR, greater autophagy flux (increased LC3-II/LC3-I ratio and reduced p62) besides increased LAMP1. Related with these effects a reduction in the ubiquitinated proteins was observed. No significant changes in the autophagic pathway were found either in hippocampus or in skeletal and cardiac muscle by exercise. Only in the liver of exercised rats mTOR phosphorylation and p62 levels increased, which could be related with beneficial metabolic effects in this organ induced by exercise. Thus, our findings suggest that long-term moderate exercise induces autophagy specifically in the cortex

Macroautophagic process was differentially modulated by long-term moderate exercise in rat brain and peripheral tissues

The autophagic process is a lysosomal degradation pathway, which is activated during stress conditions, such as starvation or exercise. Regular exercise has beneficial effects on human health, including neuroprotection. However, the cellular mechanisms underlying these effects are incompletely understood. Endurance and a single bout of exercise induce autophagy not only in brain but also in peripheral tissues. However, little is known whether autophagy could be modulated in brain and peripheral tissues by long-term moderate exercise. Here, we examined the effects on macroautophagy process of long-term moderate treadmill training (36 weeks) in adult rats both in brain (hippocampus and cerebral cortex) and peripheral tissues (skeletal muscle, liver and heart). We assessed mTOR activation and the autophagic proteins Beclin 1, p62, LC3B (LC3B-II/LC3B-I ratio) and the lysosomal protein LAMP1, as well as the ubiquitinated proteins. Our results showed in the cortex of exercised rats an inactivation of mTOR, greater autophagy flux (increased LC3-II/LC3-I ratio and reduced p62) besides increased LAMP1. Related with these effects a reduction in the ubiquitinated proteins was observed. No significant changes in the autophagic pathway were found either in hippocampus or in skeletal and cardiac muscle by exercise. Only in the liver of exercised rats mTOR phosphorylation and p62 levels increased, which could be related with beneficial metabolic effects in this organ induced by exercise. Thus, our findings suggest that long-term moderate exercise induces autophagy specifically in the cortex

L’obra de Guillaume de Machaut en el Manuscrit Mòdena, Biblioteca Estense, a.M.5.24

Entre finals del segle XIV i principis del XV es data la redacció del Manuscrit Mòdena, Biblioteca Estense, .M.5.24, un dels principals manuscrits del moment que han arribat als nostres dies, essent un element culminant pel que fa a penetració de l’art polifònic francès a la Itàlia d’inicis del ‘400. En ell es copien quatre peces de Guillaume de Machaut i l’únic poema de l’autor francès musicat per un altre compositor. En els treballs sobre el manuscrit molt sovint s’obvien aquestes quatre peces, i l’estudi sobre Machaut es fa quasi exclusivament des de les fonts franceses. Aquest treball pretén respondre, sobretot, a dues preguntes: Què ens poden explicar aquestes peces sobre el procés d’afrancesament de la música italiana? Què ens poden explicar sobre la difusió de l’obra de Machaut pel vell continent?

Encuadernaciones Mudéjares de la Biblioteca de Alfonso el Magnánimo: Ms. 574 y 576 Biblioteca de la Universitat de Barcelona

This work expect to prove relations between the bookbinding of two manuscripts conserved in the Library of the University of Barcelona and the bookbinding to realise in the workshop of bookbinding of the Library of Alfonso el Magnanimous in this court Neapolitan, across over the study of this elements and architecture, and give the denomination of bookbinding mudejar neapolitan, because they are to make in this workshop or in this defect in Italy in the middle of the XV century.

Off-Diagonal Magnetoimpedance Dependence of Magnetostriction and Anisotropy in Co-Based and Fe-Based Amorphous Ribbons

The object of this work is the comparison of domain structure and off-diagonal magnetoimpedance effect in amorphous ribbons with different magnetostriction coefficient. The Co66Fe4Ni1Si15B14 and Fe80B20 samples were obtained by melt-spinning. During the quenching procedure a 0.07 T transverse magnetic field was applied to some of the samples. Domain patterns obtained by the Bitter technique confirm that the differences on the samples are related to the different anisotropy and magnetostriction coefficient, and the quenching procedure. Small changes on the anisotropy distribution and the magnetostriction coefficient can be detected by the off-diagonal impedance spectra as a consequence of the different permeability values of the samples