Clinical usefulness of temporal artery biopsy.

To assess the diagnostic usefulness of temporal artery biopsy in temporal arteritis (TA) and establish clinical features capable of predicting its positivity we have retrospectively studied the biopsy specimens and the clinical features of 103 patients who had undergone temporal artery biopsy. Temporal artery biopsy reached a positive predictive value of 90.2% with respect to the final diagnosis based on the criteria proposed by Ellis and Ralston and the clinical course. The simultaneous presence of recent onset headache, jaw claudication, and abnormalities of the temporal arteries on physical examination had a specificity of 94.8% with respect to the histological diagnosis and of 100% with respect to final diagnosis. The presence of any of these clinical features, though of little specificity (34.4%), had a sensitivity of 100% with respect to histological diagnosis, selecting a group of patients in whom temporal artery biopsy has more discriminative value.

Una nueva forma de sigillata hispánica

Al estudiar un lote de sigillatas procedentes de Río Tinto (Huelva), encontramos parte de un vaso de terra sigillata hispánica lisa (n.o 111 de nuestro inventario), que conserva todo su perfil, desde el borde hasta el pie.

Color differences among feral pigeons (Columba livia) are not attributable to sequence variation in the coding region of the melanocortin-1 receptor gene (MC1R)

Genetic variation at the melanocortin-1 receptor (MC1R) gene is correlated with melanin color variation in many birds. Feral pigeons (Columba livia) show two major melanin-based colorations: a red coloration due to pheomelanic pigment and a black coloration due to eumelanic pigment. Furthermore, within each color type, feral pigeons display continuous variation in the amount of melanin pigment present in the feathers, with individuals varying from pure white to a full dark melanic color. Coloration is highly heritable and it has been suggested that it is under natural or sexual selection, or both. Our objective was to investigate whether MC1R allelic variants are associated with plumage color in feral pigeons.We sequenced 888 bp of the coding sequence of MC1R among pigeons varying both in the type, eumelanin or pheomelanin, and the amount of melanin in their feathers. We detected 10 non-synonymous substitutions and 2 synonymous substitution but none of them were associated with a plumage type. It remains possible that non-synonymous substitutions that influence coloration are present in the short MC1R fragment that we did not sequence but this seems unlikely because we analyzed the entire functionally important region of the gene.Our results show that color differences among feral pigeons are probably not attributable to amino acid variation at the MC1R locus. Therefore, variation in regulatory regions of MC1R or variation in other genes may be responsible for the color polymorphism of feral pigeons.

Reciprocal Translocations in Cattle: frequency estimation

Chromosomal anomalies, like Robertsonian and reciprocal translocations represent a big problem in cattle breeding as their presence induces, in the carrier subjects, a well documented fertility reduction. In cattle reciprocal translocations (RCPs, a chromosome abnormality caused by an exchange of material between nonhomologous chromosomes) are considered rare as to date only 19 reciprocal translocations have been described. In cattle it is common knowledge that the Robertsonian translocations represent the most common cytogenetic anomalies, and this is probably due to the existence of the endemic 1;29 Robertsonian translocation. However, these considerations are based on data obtained using techniques that are unable to identify all reciprocal translocations and thus their frequency is clearly underestimated. The purpose of this work is to provide a first realistic estimate of the impact of RCPs in the cattle population studied, trying to eliminate the factors which have caused an underestimation of their frequency so far. We performed this work using a mathematical as well as a simulation approach and, as biological data, we considered the cytogenetic results obtained in the last 15 years. The results obtained show that only 16% of reciprocal translocations can be detected using simple Giemsa techniques and consequently they could be present in no less than 0,14% of cattle subjects, a frequency five times higher than that shown by de novo Robertsonian translocations. This data is useful to open a debate about the need to introduce a more efficient method to identify RCP in cattle.

Respeto o vampirización. El arte como"almacén" inagotable de ideas creativas al alcance de la publicidad

Since the begínning ofAdvertising, art has been a source ofinexhaustible inspiration for the advertising creative, who have used or misused it with any limits. With more or less direct references to artists, pieces or art movements, to references to the act ofart creation itself and certain aesthetic categories. Taking into account the various semantic versions that art offers, with multiple connotative lectures, this use has not been much profitable in many occasions, not as much as it could have been. However, in other circumstances, thís use has been vampirizing, only preoccupied for the audience impact ofa well knowll reference, but despising it and reducing it to a mere reclaim. In the case ofGiocconda by Leonardo da Vinci or the Birth ofVenus by Bottícelli are significant examples ofthis use, maybe popular, ofthe art productíon. That is to say that the depository was used as a source ofreferences to enrich the lectures ofthe advertising pieces (for instance, the excellent Citroen Xsara Picasso advertisement with the fordism mass production chain) or ¡ust to allow a higher t1Otoriety (like the Chupa-Chups advertisement where the Mona Lisa heartily sucks one ofthe mythical sweets with a stick). Thanks to a selected advertising pieces, graphical and audiovisual, we will be able to go through this kind ofadvertising creation logistics, from the moment that this one decided to call out these art references that were sleeping dreamingly Oll the fair in a depository until this strictly cultural moment came.

Exploratory Factor Analysis of the contents and styles of irrational thoughts assessed by "The Attitudes and Beliefs Inventory"

The factor structure of a back translated Spanish version (Lega, Caballo and Ellis, 2002) of the Attitudes and Beliefs Inventory (ABI) (Burgess, 1990) is analyzed in a sample of 250 university students.The Spanish version of the ABI is a 48-items self-report inventory using a 5-point Likert scale that assesses rational and irrational attitudes and beliefs. 24-items cover two dimensions of irrationality: a) areas of content (3 subscales), and b) styles of thinking (4 subscales).An Exploratory Factor Analysis (Parallel Analysis with Unweighted Least Squares method and Promin rotation) was performed with the FACTOR 9.20 software (Lorenzo-Seva and Ferrando, 2013).The results reproduced the main four styles of irrational thinking in relation with the three specific contents of irrational beliefs. However, two factors showed a complex configuration with important cross-loadings of different items in content and style. More analyses are needed to review the specific content and style of such items.

Exploratory Factor Analysis of the contents and styles of irrational thoughts assessed by "The Attitudes and Beliefs Inventory"

The factor structure of a back translated Spanish version (Lega, Caballo and Ellis, 2002) of the Attitudes and Beliefs Inventory (ABI) (Burgess, 1990) is analyzed in a sample of 250 university students.The Spanish version of the ABI is a 48-items self-report inventory using a 5-point Likert scale that assesses rational and irrational attitudes and beliefs. 24-items cover two dimensions of irrationality: a) areas of content (3 subscales), and b) styles of thinking (4 subscales).An Exploratory Factor Analysis (Parallel Analysis with Unweighted Least Squares method and Promin rotation) was performed with the FACTOR 9.20 software (Lorenzo-Seva and Ferrando, 2013).The results reproduced the main four styles of irrational thinking in relation with the three specific contents of irrational beliefs. However, two factors showed a complex configuration with important cross-loadings of different items in content and style. More analyses are needed to review the specific content and style of such items.

Análisis comparativo del "inventario de actitudes y creencias" (ABI) y la "escala de actitudes disfuncionales" (DAS)

De acuerdo con los planteamientos de la Terapia Cognitiva (TC) de Aaron Beck y la terapia Racional Emotivo Conductual (TREC) de Albert Ellis, el mantenimiento de creencias rígidas y actitudes disfuncionales constituyen factores de vulnerabilidad a los trastornos psicológicos. En base a estos planteamientos, la adecuada evaluación de las creencias y actitudes disfuncionales es fundamental, no sólo para saber cuáles están en el origen y mantenimiento de la perturbación emocional que puede aquejar a una persona, sino también para su cambio y prevención, e incluso para la promoción de actitudes más funcionales o saludables.El presente estudio se centra específicamente en el análisis de las similitudes y diferencias existentes entre los instrumentos de evaluación de las creencias y actitudes disfuncionales elaborados desde tales enfoques teóricos. Concretamente, entre el Inventario de Actitudes y Creencias (ABI) y la Escala de Actitudes Disfuncionales (DAS) desarrollados desde la perspectiva de la TREC y la TC, respectivamente. Para ello se han administrado sendos cuestionarios a una muestra de 156 estudiantes universitarios con un rango de edad comprendido entre los 19 y 57 años (media: 22.03; desviación típica: 5.09), y sus puntuaciones se han sometido a diversos análisis de correlación (de Spearman y canónica) y de regresión para verificar el grado de variancia compartida, así como a un análisis factorial de componentes principales (ACP) para comprobar la estructura de la agrupación de las escalas respectivas...

Characterisation of COPD heterogeneity in the ECLIPSE cohort

Background Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE). Methods We studied 2164 clinically stable COPD patients, 337 smokers with normal lung function and 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, and amount of emphysema by computed tomography. Results COPD patients were slightly older than controls and had more pack years of smoking than smokers with normal lung function. Co-morbidities were more prevalent in COPD patients than in controls, and occurred to the same extent irrespective of the GOLD stage. The severity of airflow limitation in COPD patients was poorly related to the degree of breathlessness, health status, presence of co-morbidity, exercise capacity and number of exacerbations reported in the year before the study. The distribution of these variables within each GOLD stage was wide. Even in subjects with severe airflow obstruction, a substantial proportion did not report symptoms, exacerbations or exercise limitation. The amount of emphysema increased with GOLD severity. The prevalence of bronchiectasis was low (4%) but also increased with GOLD stage. Some gender differences were also identified. Conclusions The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.

Helena Valentí, fúria i traducció

La filòloga i novel·lista Helena Valentí i Petit (Barcelona, 1940-1990) s’exilià de ben jove a Anglaterra, on buscà en la traducció el mitjà de vida. Entre altres autors i autores, traslladà al castellà William Blake, Marilyn French, Nicholas Guild, Najib Mahfuz, Harold Robbins, Bernice Rubens, Roger T. Taylor i Doris Lessing, de la qual traduí El quadern daurat. De retorn a Catalunya, el 1974, decidí compaginar la traducció amb la narrativa pròpia. Girà a la llengua catalana Al far i Una cambra pròpia de l’anglesa Virginia Woolf i La garden party i altres contes i Un home casat i altres crueltats de la neozelandesa Katherine Mansfield. En els anys vuitanta traslladà El factor humà de Graham Greene i Jo, Claudi de Robert Graves, i féu una breu incursió en la narrativa per a joves. Viatges indiscrets de Lisa St. Aubin, un recull de contes d’autores del segle XX, fou l’última traducció.

Género y cultura popular

En uno de los capítulos de Los Simpson, la pequeña Lisa compra, emocionada, la última versión de Stacy Malibú (el equivalente a nuestra Barbie). La novedad consiste en que después de 50 años de existencia, la muñeca habla. Pero para consternación de Lisa, el repertorio de frases es de lo más indignante: "Me encantaría que en la escuela enseñaran a ir de compras", "¡Vamos a hornear unas galletas para los chicos!" o "No me preguntes: sólo soy una chica (risita vacua)". Obviamente, la comprometida y concienciada Lisa no puede quedarse de brazos cruzados y pide a su madre que la lleve a la fábrica de Stacy Malibú para presentar sus quejas. La conversación entre ambas es enormemente reveladora: aunque Marge apoya a su hija e insiste en que siempre defienda sus ideas, considera que quizás está yendo más allá de lo razonable en su denuncia de que toda una generación de niñas se comportará como Stacy Malibú y la tomará como modelo y, finalmente, concluye en tono conciliador: "Yo tuve una Stacy Malibú de pequeña y no me ha pasado nada.¡Vamos a olvidarnos de estos problemas con un gran bol de helado de fresa!". La respuesta de Lisa no deja lugar a dudas; poniendo en funcionamiento a la muñeca y situándola frente a su madre, oímos a Stacy diciendo: "¡Vamos a olvidarnos de estos problemas con un gran bol de helado de fresa!". Huelgan los comentarios.

Género y cultura popular

En uno de los capítulos de Los Simpson, la pequeña Lisa compra, emocionada, la última versión de Stacy Malibú (el equivalente a nuestra Barbie). La novedad consiste en que después de 50 años de existencia, la muñeca habla. Pero para consternación de Lisa, el repertorio de frases es de lo más indignante: "Me encantaría que en la escuela enseñaran a ir de compras", "¡Vamos a hornear unas galletas para los chicos!" o "No me preguntes: sólo soy una chica (risita vacua)". Obviamente, la comprometida y concienciada Lisa no puede quedarse de brazos cruzados y pide a su madre que la lleve a la fábrica de Stacy Malibú para presentar sus quejas. La conversación entre ambas es enormemente reveladora: aunque Marge apoya a su hija e insiste en que siempre defienda sus ideas, considera que quizás está yendo más allá de lo razonable en su denuncia de que toda una generación de niñas se comportará como Stacy Malibú y la tomará como modelo y, finalmente, concluye en tono conciliador: "Yo tuve una Stacy Malibú de pequeña y no me ha pasado nada.¡Vamos a olvidarnos de estos problemas con un gran bol de helado de fresa!". La respuesta de Lisa no deja lugar a dudas; poniendo en funcionamiento a la muñeca y situándola frente a su madre, oímos a Stacy diciendo: "¡Vamos a olvidarnos de estos problemas con un gran bol de helado de fresa!". Huelgan los comentarios.

Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity.

The capacity of a polypeptide chain to engage in an amyloid formation process and cause a conformational disease is contained in its sequence. Some of the sequences undergoing fibrillation contain critical methionine (Met) residues which in vivo can be synthetically substituted by selenomethionine (SeM) and alter their properties.