Técnicas radiológicas para la identificación anatómica del conducto dentario inferior respecto al tercer molar inferior

La correcta identificación anatómica del conducto dentario inferior, por el que circula el nervio dentario inferior, con respecto al tercer molar es esencial cuando es preciso practicar la exéresis de los cordales inferiores incluidos, puesto que la proximidad de ambas estructuras condiciona la posibilidad de lesionar dicho nervio. En este artículo, se revisa el estudio radiológico del conducto dentario inferior y se comentan las diferentes técnicas de diagnóstico por la imagen (ortopantomografía, radiografías periapicales y oclusales y tomografía axial computadorizada), así como sus diversas indicaciones y los signos radiológicos útiles para determinar la situación y trayecto del conducto dentario inferior con respecto a los ápices.

Multislice CT for assessing in-stent dimensions after left main coronary artery stenting: a comparison with three dimensional intravascular ultrasound

Objective: To evaluate the agreement between multislice CT (MSCT) and intravascular ultrasound (IVUS) to assess the in-stent lumen diameters and lumen areas of left main coronary artery (LMCA) stents. Design: Prospective, observational single centre study. Setting: A single tertiary referral centre. Patients: Consecutive patients with LMCA stenting excluding patients with atrial fibrillation and chronic renal failure. Interventions: MSCT and IVUS imaging at 912 months follow-up were performed for all patients. Main outcome measures: Agreement between MSCT and IVUS minimum luminal area (MLA) and minimum luminal diameter (MLD). A receiver operating characteristic (ROC) curve was plotted to find the MSCT cut-off point to diagnose binary restenosis equivalent to 6 mm2 by IVUS. Results: 52 patients were analysed. PassingBablok regression analysis obtained a β coefficient of 0.786 (0.586 to 1.071) for MLA and 1.250 (0.936 to 1.667) for MLD, ruling out proportional bias. The α coefficient was −3.588 (−8.686 to −0.178) for MLA and −1.713 (−3.583 to −0.257) for MLD, indicating an underestimation trend of MSCT. The ROC curve identified an MLA ≤4.7 mm2 as the best threshold to assess in-stent restenosis by MSCT. Conclusions: Agreement between MSCT and IVUS to assess in-stent MLA and MLD for LMCA stenting is good. An MLA of 4.7 mm2 by MSCT is the best threshold to assess binary restenosis. MSCT imaging can be considered in selected patients to assess LMCA in-stent restenosis

Aportaciones al proceso de iberización en el curso inferior del Ebro: el ejemplo de Sebes (Flix, Ribera d’Ebre, Tarragona)

Presentamos en este trabajo el resultado de las intervenciones efectuadas en el yacimiento de Sebes entre los años 2010 y 2011, donde hemos podido documentar la existencia de un asentamiento ibérico de nueva planta fechado en la segunda mitad del siglo vi a.C., poco tiempo después del abandono del asentamiento del Hierro I, ubicado en la parte más alta de la colina de Sebes. La proximidad entre los dos asentamientos y los restos materiales recuperados parecen indicar un ligero traslado poblacional, dentro de una dinámica interna de cambio en la sociedad ibérica, en una etapa de transición previa a la consolidación de un nuevo modelo poblacional durante el siglo v a.C.

Structural Insight into the Mode of Action of a Direct Inhibitor of Coregulator Binding to the Thyroid Hormone Receptor.

The development of nuclear hormone receptor antagonists that directly inhibit the association of the receptor with its essential coactivators would allow useful manipulation of nuclear hormone receptor signaling. We previously identified 3-(dibutylamino)-1-(4-hexylphenyl)-propan-1-one (DHPPA), an aromatic β-amino ketone that inhibits coactivator recruitment to thyroid hormone receptor β (TRβ), in a high-throughput screen. Initial evidence suggested that the aromatic β-enone 1-(4-hexylphenyl)-prop-2-en-1-one (HPPE), which alkylates a specific cysteine residue on the TRβ surface, is liberated from DHPPA. Nevertheless, aspects of the mechanism and specificity of action of DHPPA remained unclear. Here, we report an x-ray structure of TRβ with the inhibitor HPPE at 2.3-Å resolution. Unreacted HPPE is located at the interface that normally mediates binding between TRβ and its coactivator. Several lines of evidence, including experiments with TRβ mutants and mass spectroscopic analysis, showed that HPPE specifically alkylates cysteine residue 298 of TRβ, which is located near the activation function-2 pocket. We propose that this covalent adduct formation proceeds through a two-step mechanism: 1) β-elimination to form HPPE; and 2) a covalent bond slowly forms between HPPE and TRβ. DHPPA represents a novel class of potent TRβ antagonist, and its crystal structure suggests new ways to design antagonists that target the assembly of nuclear hormone receptor gene-regulatory complexes and block transcription.

Structural changes induced by daily music listening in the recovering brain after middle cerebral artery stroke: a voxel-based morphometry study

Music is a highly complex and versatile stimulus for the brain that engages many temporal, frontal, parietal, cerebellar, and subcortical areas involved in auditory, cognitive, emotional, and motor processing. Regular musical activities have been shown to effectively enhance the structure and function of many brain areas, making music a potential tool also in neurological rehabilitation. In our previous randomized controlled study, we found that listening to music on a daily basis can improve cognitive recovery and improve mood after an acute middle cerebral artery stroke. Extending this study, a voxel-based morphometry (VBM) analysis utilizing cost function masking was performed on the acute and 6-month post-stroke stage structural magnetic resonance imaging data of the patients (n = 49) who either listened to their favorite music [music group (MG), n = 16] or verbal material [audio book group (ABG), n = 18] or did not receive any listening material [control group (CG), n = 15] during the 6-month recovery period. Although all groups showed significant gray matter volume (GMV) increases from the acute to the 6-month stage, there was a specific network of frontal areas [left and right superior frontal gyrus (SFG), right medial SFG] and limbic areas [left ventral/subgenual anterior cingulate cortex (SACC) and right ventral striatum (VS)] in patients with left hemisphere damage in which the GMV increases were larger in the MG than in the ABG and in the CG. Moreover, the GM reorganization in the frontal areas correlated with enhanced recovery of verbal memory, focused attention, and language skills, whereas the GM reorganization in the SACC correlated with reduced negative mood. This study adds on previous results, showing that music listening after stroke not only enhances behavioral recovery, but also induces fine-grained neuroanatomical changes in the recovering brain.

Los inicios de la conquista romana de Iberia: los campamentos de campaña del curso inferior del río Ebro

La investigación arqueológica de los campamentos de campaña romano-republicanos localizados en el curso inferior del río Ebro permite una nueva perspectiva de estudio sobre los inicios de la conquista romana en la península ibérica.

Espigueo por la toponimia mayor del Valle Medio e Inferior del Ésera (Huesca)

El present treball pretén donar llum a una sèrie de topònims majors de la Ribagorça occidental, tot al llarg de la vall mitjana i inferior del riu Éssera. Aquests topònims es remunten a temps molt antics: preromans, romans i germànics bàsicament. Aquesta anàlisi permet apreciar l'estratigrafi a lingüística de la zona. La no-aparició de topònims d'origen àrab en el nostre treball no vol dir que no hi hagués penetració àrab a la zona, sinó que la seva arribada va ser posterior a la creació dels principals nuclis de població. Sí que hi ha topònims àrabs a la toponímia menor, que resta fora del present treball.

Pisolitos ferruginosos en el Mioceno inferior-medio de Mallorca.

El registro sedimentario Burdigaliense-Langhiense de Mallorca refleja el relleno de pequeños surcos de antepaís que se generaron por subsidencia flexural frente al orógeno bético. Este registro sinorogénico incluye una unidad inferior que caracteriza la sedimentación en una plataforma marina somera (Fm. Sant Elm) y otra superior turbidítica (Fm. Banyalbufar). En el límite entre ambas unidades se ha reconocido, en la zona central de la isla, la existencia de un nivel de pisolitos ferruginosos de menos de 20 cm de potencia. Los pisolitos llegan a superar los 6 mm de diámetro, son esféricos y están constituidos casi exclusivamente por delgadas envueltas concéntricas de goethita, aunque en los pisolitos de mayor tamaño alguna envuelta es de calcita. La posición estratigráfica del nivel de pinolitos coincide, aproximadamente, con el límite entre las dos unidades anteriormente citadas, localizándose inmediatamente antes del inicio de la sedimentación turbidítica, y se correspondería con el máximo transgresivo en la cuenca marina. Tanto el vulcanismo Burdigaliense que ha sido reconocido en la zona como la removilización de suelos lateríticos en relación con la transgresión marina pudieron haber actuado como fuentes suministradoras del hierro.

Multislice CT for assessing in-stent dimensions after left main coronary artery stenting: a comparison with three dimensional intravascular ultrasound

Objective: To evaluate the agreement between multislice CT (MSCT) and intravascular ultrasound (IVUS) to assess the in-stent lumen diameters and lumen areas of left main coronary artery (LMCA) stents. Design: Prospective, observational single centre study. Setting: A single tertiary referral centre. Patients: Consecutive patients with LMCA stenting excluding patients with atrial fibrillation and chronic renal failure. Interventions: MSCT and IVUS imaging at 9-12 months follow-up were performed for all patients. Main outcome measures: Agreement between MSCT and IVUS minimum luminal area (MLA) and minimum luminal diameter (MLD). A receiver operating characteristic (ROC) curve was plotted to find the MSCT cut-off point to diagnose binary restenosis equivalent to 6 mm2 by IVUS. Results: 52 patients were analysed. Passing-Bablok regression analysis obtained a β coefficient of 0.786 (0.586 to 1.071) for MLA and 1.250 (0.936 to 1.667) for MLD, ruling out proportional bias. The α coefficient was −3.588 (−8.686 to −0.178) for MLA and −1.713 (−3.583 to −0.257) for MLD, indicating an underestimation trend of MSCT. The ROC curve identified an MLA ≤4.7 mm2 as the best threshold to assess in-stent restenosis by MSCT. Conclusions: Agreement between MSCT and IVUS to assess in-stent MLA and MLD for LMCA stenting is good. An MLA of 4.7 mm2 by MSCT is the best threshold to assess binary restenosis. MSCT imaging can be considered in selected patients to assess LMCA in-stent restenosis

Los inicios de la conquista romana de Hispania. Los campamentos de campaña del curso inferior del rio Ebro.

La investigación arqueológica de los campamentos de campaña romano-republicanos localizados en el curso inferior del río Ebro permite una nueva perspectiva de estudio sobre los inicios de la conquista romana en la península ibérica.

Evolución tectónica y sedimentaria durante el Priaboniense superior-Mioceno inferior, en el frente de cabalgamiento de las Sierras Marginales occidentales

Se han distinguido cuatro complejos sedimentarios del Eoceno superior-Mioceno inferior en los depósitos continentales del margen norte de la cuenca del Ebro...

Influencia de la tectónica en la sedimentación continental de la cuenca del Vallés-Penedés (Prov.Barcelona, España) durante el Mioceno inferior.

A very important alluvial fan clastic sedimentation, took place in the NNESSW trending Valles-Penedes graben (northeastem Spain) during Miocene time. Shallow lacustrine and paludine areas developed in distal zones of these alluvial fan complexes during Burdigalian (Early Miocene). At that time both facies development and their distribution were closely controlled by tectonic activity. Fault scarp retreat and back-faulting processes in the southeastem edge of the basin (observed in westem Valles afea), originated an expansive advance of distal alluvial-fan facies in that direction. The decreasing or cessation of the activity of the southeastern margin fault ca~sedi,n Late Burdigalian time (while faults in the northwestern margin were still active) facies redistribution, and gave way to the assymetry of the basin. Finally lacustrine, marine and transitional deposits of late burdigalian and langhian age, were laid down overlapping the southeastem inactive margins.

Comentarios sobre 'Aportaciones al conocimiento de la compresion tardia en la Cordillera Iberica centrooriental: la cuenca neogena inferior del Mijares (Teruel-Castellon)'

El artículo que se comenta y otros trabajos publicados anteriormente por J.L. Simón, individualmente o en colaboración, establecen una evolución de la deformación terciaria compresiva y distensiva en el ámbito de la Cadena Ibérica que, en mi opinión, tiene aspectos discutibles, ya que se basa, parcialmente, en algunos datos poco representativos y en una aplicación de los conceptos de comprensión y de distensión a mi entender errónea. Esta es la razón de los presentes comentarios que se centrarán, principalmente, en la discusión de las edades del final de la comprensión y del inicio de la distensión, en el uso de las estructuras frágiles a la escala del afloramiento y en los conceptos de compresión y de distensión.

Structural Insight into the Mode of Action of a Direct Inhibitor of Coregulator Binding to the Thyroid Hormone Receptor.

The development of nuclear hormone receptor antagonists that directly inhibit the association of the receptor with its essential coactivators would allow useful manipulation of nuclear hormone receptor signaling. We previously identified 3-(dibutylamino)-1-(4-hexylphenyl)-propan-1-one (DHPPA), an aromatic β-amino ketone that inhibits coactivator recruitment to thyroid hormone receptor β (TRβ), in a high-throughput screen. Initial evidence suggested that the aromatic β-enone 1-(4-hexylphenyl)-prop-2-en-1-one (HPPE), which alkylates a specific cysteine residue on the TRβ surface, is liberated from DHPPA. Nevertheless, aspects of the mechanism and specificity of action of DHPPA remained unclear. Here, we report an x-ray structure of TRβ with the inhibitor HPPE at 2.3-Å resolution. Unreacted HPPE is located at the interface that normally mediates binding between TRβ and its coactivator. Several lines of evidence, including experiments with TRβ mutants and mass spectroscopic analysis, showed that HPPE specifically alkylates cysteine residue 298 of TRβ, which is located near the activation function-2 pocket. We propose that this covalent adduct formation proceeds through a two-step mechanism: 1) β-elimination to form HPPE; and 2) a covalent bond slowly forms between HPPE and TRβ. DHPPA represents a novel class of potent TRβ antagonist, and its crystal structure suggests new ways to design antagonists that target the assembly of nuclear hormone receptor gene-regulatory complexes and block transcription.