Mitochondrial fatty acid oxidation in obesity

Significance: Current lifestyles with high-energy diets and little exercise are triggering an alarming growth in obesity. Excess of adiposity is leading to severe increases in associated pathologies, such as insulin resistance, type 2 diabetes, atherosclerosis, cancer, arthritis, asthma, and hypertension. This, together with the lack of efficient obesity drugs, is the driving force behind much research. Recent Advances: Traditional anti-obesity strategies focused on reducing food intake and increasing physical activity. However, recent results suggest that enhancing cellular energy expenditure may be an attractive alternative therapy. Critical Issues: This review evaluates recent discoveries regarding mitochondrial fatty acid oxidation (FAO) and its potential as a therapy for obesity. We focus on the still controversial beneficial effects of increased FAO in liver and muscle, recent studies on how to potentiate adipose tissue energy expenditure, and the different hypotheses involving FAO and the reactive oxygen species production in the hypothalamic control of food intake. Future Directions: The present review aims to provide an overview of novel anti-obesity strategies that target mitochondrial FAO and that will definitively be of high interest in the future research to fight against obesity-related disorders.

Immortalitat

Els humans sempre hem buscat la immortalitat, i potser de tant buscar-la en- cara no ens hem adonat que ja en som. Bé, de fet, com a persones individuals, no som pas immortals, però els nostres gens si que ho són. El raonament és molt simple: si tots els éssers vius descendim d'un mateix ancessor, tots haurem heretat característiques d'ell, codificades al material genètic. Per tant, en tots nosaltres sobreviuen característiques d'aquell reeixit intent vital primigeni, de la mateixa manera que en els nostres descendents, siguin humans o pertanyin a qualsevol altra espècie humanoide successora nostra que la selecció natural afavoreixi, si es dóna el cas, sobreviuran els nostres gens, assegurant-nos la immortalitat genètica [...].