Disease-corrected haematopoietic progenitors from Fanconi anemia induced pluripotent stem cells

The generation of induced pluripotent stem (iPS) cells has enabled the derivation of patient-specific pluripotent cells andprovided valuable experimental platforms to model human disease. Patient-specific iPS cells are also thought to hold greattherapeutic potential, although direct evidence for this is still lacking. Here we show that, on correction of the genetic defect,somatic cells from Fanconi anaemia patients can be reprogrammed to pluripotency to generate patient-specific iPS cells. These cell lines appear indistinguishable from human embryonic stem cells and iPS cells from healthy individuals. Most importantly, we show that corrected Fanconi-anaemia-specific iPS cells can give rise to haematopoietic progenitors of the myeloid and erythroid lineages that are phenotypically normal, that is, disease-free. These data offer proof-of-concept that iPS cell technology can be used for the generation of disease-corrected, patient-specific cells with potential value for cell therapy applications.

A new hybrid summarizer based on vector Space model, statistical physics and linguistics

In this article we present a hybrid approach for automatic summarization of Spanish medical texts. There are a lot of systems for automatic summarization using statistics or linguistics, but only a few of them combining both techniques. Our idea is that to reach a good summary we need to use linguistic aspects of texts, but as well we should benefit of the advantages of statistical techniques. We have integrated the Cortex (Vector Space Model) and Enertex (statistical physics) systems coupled with the Yate term extractor, and the Disicosum system (linguistics). We have compared these systems and afterwards we have integrated them in a hybrid approach. Finally, we have applied this hybrid system over a corpora of medical articles and we have evaluated their performances obtaining good results.

Infraestructuras y desarrollo económico en el Pirineo Central (1850-2000)

This paper is aimed at describing the impact of infrastructure on the economic evolution of Central Pyrenees (i.e., Huesca and the Catalan"Alt Pirineu"). The text analyses if investment in railways, roads and dams favoured economic development or, on the contrary, was just an instrument to extract domestic resources. The paper distinguishes among three different periods. Firstly, during the second half of the nineteenth century and the first few years of the twentieth century, the lack of railway connections prevented the economic development of the area. Secondly, between the first decades of the twentieth century and 1975, a road network was set up that reinforced the economic decadence of the most depressed valleys, and the construction of large dams was a powerful factor of depopulation all over the region. Finally, from 1975 onwards, some trends may be observed towards the correction of the previous policies.

Rigor metodológico e investigación filológica

In recent decades, technological advances have made extensive documentation available to us. But the philologist must be aware of the dangers of poor use of the documentary corpus in order to avoid creating dreaded ghost words. In this paper we recall the main sources of this type of error: folk etymology phenomena among speakers, copyists" errors, transcribers" errors in the interpretation of some abbreviations and graphic variants of the manuscripts, onomastic changes introduced by cartographers" ignorance of linguistic variants, gaps in the dating of some documents, confusion in the processes of lemmatization and the evaluation of texts... All these sources of error contribute, to a greater or lesser degree, to the distortion or to the masking of the data on which the research of philologists is based. Hence the importance of philological rigour in the transmission and study of ancient texts.

La gestualidad de la barba y el mentón en la Antigüedad romana

Beards and chins are two parts of the body that are associated with a large number of gestures. This paper examines a number of texts in which these gestures appear and the meaning they convey. The analysis was conducted by distinguishing between self-adaptor gestures (those that do not involve a second party), alter-directed adaptors (those that, to the contrary, involve the intervention of another person) and object-adaptors (a category that encompasses gestures involving an object).

Explorando los discursos de las organizaciones

Después de comentar algunas de las orientaciones con que se estudian los discursos en las organizaciones (empresas o instituciones), presentamos dos clasificaciones discursivas, basadas respectivamente en el organigrama (formal / informal, horizontal / vertical, etc.) y en la función comunicativa (discursos técnico-científicos, organizativos, comerciales y protocolarios).También establecemos una tipología de intervenciones lingüísticas en organizaciones, según tomen como objeto de trabajo la estructura organizativa, los recursos humanos, el registro o un discurso particular.

Re-writing and Its Pedagogical Value: A Case Study

Tenint en compte el temps i la energia que els mestres i professors dediquen a la correcció de redaccions i produccions escrites i el poc efecte que aquestes semblen tenir en altres produccions dels aprenents, es va dissenyar la recerca que es presenta en aquest article. Els resultats de l'estudi semblen suggerir que les correccions no faciliten l'aprenentatge. Com presentem aquesta activitat de retroalimentació a l'alumnat i la posició que li donem dins d'un enfocament basat en el procés de l'escriptura seran clau per fer que les correccions siguin facilitadores de l'aprenentatge de la producció escrita.

Feedback i oportunitats de millora: una avaluació orientada a l"aprenentatge actiu

This paper analyzes an innovative experience of formative assessment aimed at improving the teaching of Statistics, which could be easily extrapolated to other studies. We detail the implementation of the double correction, consisting of correcting students' work twice. With the first correction, carried out by classmates according to a rubric developed by the academic, possible errors or deficiencies are discovered, and students are provided with a feedback that allows them to correct and improve their work before being graded by the teacher; whereas in the second correction of the work, once upgraded, the professor evaluates and grades the work. As a result, there is a significant improvement in the quality of students" works, and an active learning from their own mistakes. Both contents and competencies are reinforced by the experience.

Sticky income inequality in the Spanish transition (1973-1990)

This paper investigates the evolution of income inequality in Spain during its transition to democracy, suggesting a method for the correction of under-reporting of earnings and profits in the Household Budget Surveys’ data. The contribution is twofold: the methodological proposal, based on income expenditure discrepancy and scaling-up to National Accounts, improves on previous work, and can be convenient for similar historical sources in other countries. Secondly, its application results in an alternative history of the distribution of income in this case, changing the levels and also the observed trend. Previous literature asserted a substantial equalization, related to the democratization process, while after the adjustment inequality in disposable income is shown to have been quite persistent.

El Periodisme esportiu i els gèneres periodístics: una anàlisi quantitativa a partir d'un corpus de premsa catalana i espanyola d'informació general

Prenent com a marc el món de l’esport i la premsa d'informació general amb presència a Catalunya, el present treball es proposa investigar quina cobertura dóna aquest tipus de premsa a l’esport en general i al futbol en particular. Per a dur a terme aquesta tasca ens centrarem en la utilització dels gèneres periodístics en la redacció dels textos

L'Ús del mètode verbotonal per a la correcció fonètica: estudi de cas d'un parlant de català com a L2 amb problemes de pronúncia de les laterals palatals

Aquest treball pretén ser l’estudi i la correcció fonètica d’un parlant de castellà com a primera llengua que té la llengua catalana coma segona llengua i presenta un problema a l’hora de pronunciar les laterals palatals. Per tant, és l’estudi d’un cas molt concret. Per a fer aquest estudi s’ha seguit el mètode verbotonal de correcció fonètica, ja que també es pretén comprovar la funcionalitat d’aquest mètode i els resultats possibles

Utilización de software de corrección automática en el campo de las ciencias de la salud

We live in an era of profound changes in university education. The implementation of Bologna plan has led us to raise new teaching methodologies, to review the role of the student, competency assessment, the incorporation of ICT. Unthinkable acts, one or two decade ago. The TIC concept is very broad and is attributed to the media, processes and content usage. Inside the supports and platforms, we stress tools that allow automatic correction of exercises, because they are instruments of great educational value because instantly they assess students and provide instant feedback about the knowledge that they have either as message support or note. If the power of these tools, we add the Internet, using e-learning environment, the results allow us to work, edit, evaluate, resolve doubts, and so on, anywhere, anytime. We present part of a platform and the results of its use in the field of health sciences

Estimaciones de segunda generación del PIB de la Europa Latina: España, Francia, Italia, Portugal (1950-2013)

Los cambios conceptuales y metodológicos en los sistemas empleados para la construcción de la Contabilidad Nacional de todos los países, especialmente a causa de la implantación en la UE del SEC 95, así como la revisión y corrección de los datos de población más actuales obligan a introducir modificaciones muy sustanciales en las series históricas de Cuentas Nacionales por medio de la técnica de la retropolación. La realización de los nuevos cálculos, que pueden ser calificados de auténticas estimaciones de segunda generación, ofrece para España, Francia, Italia y Portugal resultados muy interesantes. Las tasas de crecimiento acumulativo anual para el conjunto del período son muy semejantes entre sí, aunque identifican a la economía española como la que más creció, tanto en la producción de bienes y servicios como en la dimensión demográfica y también en PIB por habitante.