Bitàcoles i sindicació de continguts: dues eines per difondre informació

The article describes blogs and content syndication as tools for disseminating information in libraries and other information centres, as well as in educational and research environments. The authors begin by defining each of these tools, followed by a review of their history and a discussion of how they have been used. Finally, possible applications are suggested for library environments and research spaces, while offering considerations about what activities the library community might carry out in order to convert these tools into an effective means of communication

Bitácoras y sindicación de contenidos: dos herramientas para difundir información

The article describes blogs and content syndication as tools for disseminating information in libraries and other information centres, as well as in educational and research environments. The authors begin by defining each of these tools, followed by a review of their history and a discussion of how they have been used. Finally, possible applications are suggested for library environments and research spaces, while offering considerations about what activities the library community might carry out in order to convert these tools into an effective means of communication

La mobilitat internacional d'estudiants de la Facultat de Biblioteconomia i Documentació de la Universitat de Barcelona en el marc del programa Erasmus: perspectiva i valoració

We review the participation of the Faculty of Library Sciences and Documentation of the University of Barcelona in the Erasmus program since 1993. In general, student participation has been low. We present the results of a study conducted in May 2007 among the students of the Faculty, designed a) to assess their experience of the Erasmus program and their evaluation of it and b) to promote student participation. Though the vast majority of students have heard of the Erasmus program, their awareness of specific aspects of the program is relatively low

Els fons i les col·leccions d'arxiu a les biblioteques: models per al seu control i accés

First, we examine the context of creation of special collection units in libraries, and the reasons why libraries compile archive materials and collections. Second, we focus on the techniques used in library environments to describe archive materials and collections and to guarantee their accessibility. We examine the models used in the United States and the United Kingdom to describe and access these materials, and the cooperative projects launched in these two countries in the past few years. Finally, we offer a preliminary analysis of how these types of materials are currently dealt with in Catalan libraries, and issue some recommendations to improve their archiving and access.

Los fondos y las colecciones de archivo en las bibliotecas: modelos para su control y acceso

First, we examine the context of creation of special collection units in libraries, and the reasons why libraries compile archive materials and collections. Second, we focus on the techniques used in library environments to describe archive materials and collections and to guarantee their accessibility. We examine the models used in the United States and the United Kingdom to describe and access these materials, and the cooperative projects launched in these two countries in the past few years. Finally, we offer a preliminary analysis of how these types of materials are currently dealt with in Catalan libraries, and issue some recommendations to improve their archiving and access.

Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis

Background: Metabolic flux profiling based on the analysis of distribution of stable isotope tracer in metabolites is an important method widely used in cancer research to understand the regulation of cell metabolism and elaborate new therapeutic strategies. Recently, we developed software Isodyn, which extends the methodology of kinetic modeling to the analysis of isotopic isomer distribution for the evaluation of cellular metabolic flux profile under relevant conditions. This tool can be applied to reveal the metabolic effect of proapoptotic drug edelfosine in leukemia Jurkat cell line, uncovering the mechanisms of induction of apoptosis in cancer cells. Results: The study of 13C distribution of Jukat cells exposed to low edelfosine concentration, which induces apoptosis in ¿5% of cells, revealed metabolic changes previous to the development of apoptotic program. Specifically, it was found that low dose of edelfosine stimulates the TCA cycle. These metabolic perturbations were coupled with an increase of nucleic acid synthesis de novo, which indicates acceleration of biosynthetic and reparative processes. The further increase of the TCA cycle fluxes, when higher doses of drug applied, eventually enhance reactive oxygen species (ROS) production and trigger apoptotic program. Conclusion: The application of Isodyn to the analysis of mechanism of edelfosine-induced apoptosis revealed primary drug-induced metabolic changes, which are important for the subsequent initiation of apoptotic program. Initiation of such metabolic changes could be exploited in anticancer therapy.

Nanotecnologies en mecànica molecular i cel·lular

Algunes nanotècniques recents permeten la manipulació de biomolècules i cèl·lules en escala nanomètrica amb la mesura simultània de la força aplicada amb resolució de piconewtons. Aquestes escales de desplaçament i força, i la possibilitat de treballar en medi líquid, fan que siguin eines molt útils per a l'estudi de les propietats mecàniques de molècules i cèl·lules individuals en condicions fisiològiques. Entre les tècniques més utilitzades es troben el microscopi de força atòmica, les trampes de làser i les microesferes magnètiques. En aquest treball es descriuen els principis de funcionament d'aquestes tècniques en aplicacions biològiques i, en particular, en l'estudi de la mecànica molecular i cel·lular.

Enhancement of the photoelectrochemical properties of Cl-doped ZnO nanowires by tuning their coaxial doping profile

Arrays of vertically aligned ZnO:Cl/ZnO core-shell nanowires were used to demonstrate that the control of the coaxial doping profile in homojunction nanostructures can improve their surface charge carrier transfer while conserving potentially excellent transport properties. It is experimentally shown that the presence of a ZnO shell enhances the photoelectrochemical properties of ZnO:Cl nanowires up to a factor 5. Likewise, the ZnO shell promotes the visible photoluminescence band in highly conducting ZnO:Cl nanowires. These lines of evidence are associated with the increase of the nanowires" surface depletion layer

Buy-and-Hold Strategies and Comonotonic Approximations

[cat] En aquest article estudiem estratègies “comprar i mantenir” per a problemes d’optimitzar la riquesa final en un context multi-període. Com que la riquesa final és una suma de variables aleatòries dependents, on cadascuna d’aquestes correspon a una quantitat de capital que s’ha invertit en un actiu particular en una data determinada, en primer lloc considerem aproximacions que redueixen l’aleatorietat multivariant al cas univariant. A continuació, aquestes aproximacions es fan servir per determinar les estratègies “comprar i mantenir” que optimitzen, per a un nivell de probabilitat donat, el VaR i el CLTE de la funció de distribució de la riquesa final. Aquest article complementa el treball de Dhaene et al. (2005), on es van considerar estratègies de reequilibri constant.

Drug price differentials caused by de-listing and price cap policies

This paper analyses the behaviour of pharmaceutical companies that face the threat of having their drugs excluded from reimbursement and the markets characterised also by price caps. We conclude that price elasticity of demand and cost differentials cause the price discounts which drug firms offer to health care organisations. Additionally, we conclude that price cap regulations affect the time path of prices, resulting in higher prices for new products and lower prices for old products.

Late Neogene lacustrine record and paleogeography in the Quillagua-Llamara basin, Central Andean fore-arc (Northern Chile)

The Cenozoic QuillaguaLlamara basin (northern Chile, Central Andes) is an asymmetrical, intramassif fore-arc basin with a relatively wide northern sector separated from a narrower southward extension by a basement threshold. The north- ern sector was characterised by a noticeable Oligocene?late Neogene alluvial-fan and lacustrine dominated deposition which resulted in sequences up to 900 m thick, whereas the southern sector was often a bypass zone with thinner fluvial and lacustrine sediment accumulation.

Buy-and-Hold Strategies and Comonotonic Approximations

[cat] En aquest article estudiem estratègies “comprar i mantenir” per a problemes d’optimitzar la riquesa final en un context multi-període. Com que la riquesa final és una suma de variables aleatòries dependents, on cadascuna d’aquestes correspon a una quantitat de capital que s’ha invertit en un actiu particular en una data determinada, en primer lloc considerem aproximacions que redueixen l’aleatorietat multivariant al cas univariant. A continuació, aquestes aproximacions es fan servir per determinar les estratègies “comprar i mantenir” que optimitzen, per a un nivell de probabilitat donat, el VaR i el CLTE de la funció de distribució de la riquesa final. Aquest article complementa el treball de Dhaene et al. (2005), on es van considerar estratègies de reequilibri constant.

Drug price differentials caused by de-listing and price cap policies

This paper analyses the behaviour of pharmaceutical companies that face the threat of having their drugs excluded from reimbursement and the markets characterised also by price caps. We conclude that price elasticity of demand and cost differentials cause the price discounts which drug firms offer to health care organisations. Additionally, we conclude that price cap regulations affect the time path of prices, resulting in higher prices for new products and lower prices for old products.

L'Acadèmia d'Estudiants de medicina : Barcelona, 1845-1850

Amb aquest treball es dona testimoni de l'existència i activitats de l'Acadèmia d'Estudiants de Medicina entre els anys 1845 i 1850, una associació que agrupava els estudiants dels dos últims anys de Medicina. A més a més, els autors fan una descricpció acurada del marc acadèmic per a l'estudi de la medicina en aquella època: el funcionament de la facultat, el nombre de catedràtics, professors i alumnes, les instal·lacions, etc. El treball conté també un registre de les sessions acadèmiques (a raó d'una per setmana) cel·lebrades de les què es guarda referència. Ja per últim, s'inclouen a l'addenda, tres memòries amb tres dissertacions de mans d'Eliseu Forest i Cardona, Antoni de la Creu Roca i Flaquer i Francesc Sunyer i Capdevila.

Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis

Background: Metabolic flux profiling based on the analysis of distribution of stable isotope tracer in metabolites is an important method widely used in cancer research to understand the regulation of cell metabolism and elaborate new therapeutic strategies. Recently, we developed software Isodyn, which extends the methodology of kinetic modeling to the analysis of isotopic isomer distribution for the evaluation of cellular metabolic flux profile under relevant conditions. This tool can be applied to reveal the metabolic effect of proapoptotic drug edelfosine in leukemia Jurkat cell line, uncovering the mechanisms of induction of apoptosis in cancer cells. Results: The study of 13C distribution of Jukat cells exposed to low edelfosine concentration, which induces apoptosis in ¿5% of cells, revealed metabolic changes previous to the development of apoptotic program. Specifically, it was found that low dose of edelfosine stimulates the TCA cycle. These metabolic perturbations were coupled with an increase of nucleic acid synthesis de novo, which indicates acceleration of biosynthetic and reparative processes. The further increase of the TCA cycle fluxes, when higher doses of drug applied, eventually enhance reactive oxygen species (ROS) production and trigger apoptotic program. Conclusion: The application of Isodyn to the analysis of mechanism of edelfosine-induced apoptosis revealed primary drug-induced metabolic changes, which are important for the subsequent initiation of apoptotic program. Initiation of such metabolic changes could be exploited in anticancer therapy.