La cartografía del Estado Mayor del Ejército de Tierra republicano durante la Guerra Civil española. El archivo del general Vicente Rojo

En los últimos años, se ha llevado a cabo un considerable esfuerzo de análisis y catalogación de la ingente cantidad de mapas militares, planos, croquis y vistas panorámicas realizados durante la Guerra Civil española, pero aún quedan múltiples aspectos por investigar. En este artículo, analizamos la formación cartográfica del general Vicente Rojo -el jefe del Estado Mayor del Ejército de Tierra republicano-, las relaciones de Rojo con la cartografía durante la Guerra Civil y la cartografía militar contenida en su archivo personal, que se custodia en el Archivo Histórico Nacional de Madrid. Dicha cartografía posee un gran valor cartográfico y militar, porque fue utilizada por el Estado Mayor del Ejército de Tierra republicano durante el período en que Rojo estuvo al frente del mismo, y porque contiene una serie de documentos cartográficos manuscritos inéditos de gran importancia para comprender el desarrollo de algunas de las operaciones bélicas principales.

Portafolios electrónicos para propósitos múltiples: aspectos de diseño, de uso y de evaluación

La Carpeta Digital es un sistema generador de portafolios electrónicos diseñado y desarrollado a partir de principios pedagógicos y tecnológicos. Estos principios están basados en la idea del espacio del portafolios no como algo exclusivamente ligado a su uso escolar o académico, sino también a su utilización personal. En este artículo se presenta, en primer lugar, un acercamiento al proceso de creación de la Carpeta Digital para mostrar después, de forma concreta y descriptiva, la herramienta a través de sus funcionalidades. Un segundo apartado del artículo se centra en la experiencia de uso de esta herramienta en contextos universitarios, en concreto en varias asignaturas de la Universidad de Barcelona durante dos cursos académicos.

Didáctica de la Expresión Musical. Una revisión del desarrollo del currículo

[spa] Con el fin de elaborar un estudio sobre la interrelación -o falta de ella- entre práctica educativa e investigación en educación musical, presentamos aquí un estudio de las distintas etapas por las que ha pasado el desarrollo del currículo en educación musical. Además tomamos partido y abogamos por un desarrollo del currículo que tenga en cuenta el contexto educativo-musical, basado en datos provenientes de la investigación educativa, y que preste atención fundamentalmente al plano artístico y estético. Hacemos una apuesta de futuro por un currículo crítico, haciendo por tanto un giro copernicano desde el tradicional interés por el contenido musical hasta la contribución de la música a los objetivos educativos del sistema escolar.

Martensitic phase transformation in rapidly solidified Mn50Ni40In10 alloy ribbons

Heusler alloy Mn50Ni40In10 was produced as preferentially textured ribbon flakes by melt spinning, finding the existence of martensitic-austenic transformation with both phases exhibiting ferromagnetic ordering. A microcrystalline three-layered microstructure of ordered columnar grains grown perpendicularly to ribbon plane was formed between two thin layers of smaller grains. The characteristic temperatures of the martensitic transformation were MS=213 K, Mf=173 K, AS=222 K, and Af=243 K. Austenite phase shows a cubic L21 structure (a=0.6013(3) nm at 298 K and a Curie point of 311 K), transforming into a modulated fourteen-layer modulation monoclinic martensite

Thermal and magnetic field-induced martensite-austenite transition in Ni50.3Mn35.3Sn14.4 ribbons

Thermal and field-induced martensite-austenite transition was studied in melt spun Ni50.3Mn35.3Sn14.4 ribbons. Its distinct highly ordered columnarlike microstructure normal to ribbon plane allows the direct observation of critical fields at which field-induced and highly hysteretic reverse transformation starts (H=17kOe at 240K), and easy magnetization direction for austenite and martensite phases with respect to the rolling direction. Single phase L21 bcc austenite with TC of 313K transforms into a 7M orthorhombic martensite with thermal hysteresis of 21K and transformation temperatures of MS=226K, Mf=218K, AS=237K, and Af=244K

L"educació davant la societat digital: presentació

Els articles reunits en aquest monogràfic, que és una iniciativa conjunta de la revista Temps d"Educació i de la revista en línia Interactive Educational Multimedia, reflexionen sobre les conseqüències educatives de la societat digital.1 És veritat que se n"ha escrit molt, i que és només el principi dels canvis que s"estan produint: comparats a vegades amb la impremta i altres vegades amb la pròpia escriptura, molts autors acostumen a situar la revolució digital per damunt de totes les altres revolucions tecnològiques. Al costat d"aquestes tecnofilies, en determinats moments completament acrítiques, la reflexió que qüestiona els canvis ha anat minvant progressivament davant l"avenç generalitzat de les telecomunicacions i de la informàtica, potser com a resultat d"un sentiment d"inevitabilitat. Afortunadament no és el cas dels articles reunits per a aquest monogràfic que incorpora diferents treballs d"un alt contingut.

Comparison of flag leaf and ear photosynthesis with biomass and grain yield of durum wheat under various water conditions and genotypes

Photosynthetic activity of cereals has traditionally been studied using leaves, thus neglecting the role of other organs such as ears. Here, we studied the effects of water status and genotypes on the photosynthetic activity of the flag leaf blade and the ear of durum wheat. The various parameters related to the photosynthetic activity were analysed in relation to the total above-ground plant biomass and grain yield at maturity. Four local varieties plus two cultivars adapted to the semiarid areas of South Morocco were grown in pots in a greenhouse. Five different water treatments were maintained from the beginning of stem elongation to maturity, when shoot biomass and grain yield were recorded. The net photosynthesis (A), stomatal conductance (gs) and transpiration (T) of the ear and the flag leaf were measured at anthesis. In both organs these factors decreased significantly with water deficit, whereas the A/T and A/gs ratios increased. The genotype effect was also significant for all traits studied. Whole-organ photosynthesis was much higher in the ear than in the flag leaf in well-watered conditions. As water stress developed, photosynthesis decreased less in the ear than in the flag leaf. Whole-ear photosynthesis correlated better than flag leaf photosynthesis with biomass and yield. Nevertheless, the relationships of the whole flag leaf with biomass and yield improved as the water stress became more severe, suggesting a progressive shift of yield from sink to source limitation. For all water regimes the ratios A/gs and A/T of the ear also showed a higher (negative) correlation with both biomass and yield than those of the flag leaf. The results indicate that the ear has a greater photosynthetic role than the flag leaf in determining grain yield, not only in drought but also in the absence of stress.

Automatic filtering and substantiation of drug safety signals

Drug safety issues pose serious health threats to the population and constitute a major cause of mortality worldwide. Due to the prominent implications to both public health and the pharmaceutical industry, it is of great importance to unravel the molecular mechanisms by which an adverse drug reaction can be potentially elicited. These mechanisms can be investigated by placing the pharmaco-epidemiologically detected adverse drug reaction in an information-rich context and by exploiting all currently available biomedical knowledge to substantiate it. We present a computational framework for the biological annotation of potential adverse drug reactions. First, the proposed framework investigates previous evidences on the drug-event association in the context of biomedical literature (signal filtering). Then, it seeks to provide a biological explanation (signal substantiation) by exploring mechanistic connections that might explain why a drug produces a specific adverse reaction. The mechanistic connections include the activity of the drug, related compounds and drug metabolites on protein targets, the association of protein targets to clinical events, and the annotation of proteins (both protein targets and proteins associated with clinical events) to biological pathways. Hence, the workflows for signal filtering and substantiation integrate modules for literature and database mining, in silico drug-target profiling, and analyses based on gene-disease networks and biological pathways. Application examples of these workflows carried out on selected cases of drug safety signals are discussed. The methodology and workflows presented offer a novel approach to explore the molecular mechanisms underlying adverse drug reactions

Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide

Cells respond to different kind of stress through the coordinated activation of signaling pathways such as MAPK or p53. To find which molecular mechanisms are involved, we need to understand their cell adaptation. The ribosomal protein, S6 kinase 1 (S6K1), is a common downstream target of signaling by hormonal or nutritional stress. Here, we investigated the initial contribution of S6K1/MAPK signaling pathways in the cell response to oxidative stress produced by hydrogen peroxide (H2O2). To analyze S6K1 activation, we used the commercial anti-phospho-Thr389-S6K1 antibody most frequently mentioned in the bibliography. We found that this antibody detected an 80-90 kDa protein that was rapidly phosphorylated in response to H2O2 in several human cells. Unexpectedly, this phosphorylation was insensitive to both mTOR and PI3K inhibitors, and knock-down experiments showed that this protein was not S6K1. RSK and MSK proteins were candidate targets of this phosphorylation. We demonstrated that H2O2 stimulated phosphorylation of RSK and MSK kinases at residues that are homologous to Thr389 in S6K1. This phosphorylation required the activity of either p38 or ERK MAP kinases. Kinase assays showed activation of RSK and MSK by H2O2. Experiments with mouse embryonic fibroblasts from p38 animals" knockout confirmed these observations. Altogether, these findings show that the S6K1 signaling pathway is not activated under these conditions, clarify previous observations probably misinterpreted by non-specific detection of proteins RSK and MSK by the anti-phospho-Thr389-S6K1 antibody, and demonstrate the specific activation of MAPK signaling pathways through ERK/p38/RSK/MSK by H2O2.

Modelización matemática

La modelización matemática pretende describir la realidad en términos matemáticos,una tarea difícil y que, sin embargo,está jalonada de éxitos sorprendentes. Elproceso de modelización matemática puede esquematizarse en el cuadro de la figura.A partir de un problema dado, de Índole físi ca, tecnológica, biológica. económica.ete., la primera etapa consiste en la formulación matemática del problema. Suobjetivo es asocia rle un modelo matemático que lo describa. Ello obliga a teneren cuenta únicamente una parte de las características que in tervienen en el problemainicial y prescindir de otras que se consideran accesorias o incluso irrclevantespara su resolución. Hay que hacer hipótesis sobre la influencia de los diferentesfactores que intervienen . Son elecciones difíciles y susceptibles de ser modificadasposteriormente. Para obtener el modelo matemático tenemos que conseguir traduciral lenguaje matemático las características seleccionadas. En el modelo matemáticoéstas apareceran en la forma de variables, funciones, ecuaciones, ete. A continuacióndebemos resolver el problema matemático resultante para obtener resultados concretos,normalmente numéricos.

The EU-ADR Web Platform: delivering advanced pharmacovigilance tools

PURPOSE: Pharmacovigilance methods have advanced greatly during the last decades, making post-market drug assessment an essential drug evaluation component. These methods mainly rely on the use of spontaneous reporting systems and health information databases to collect expertise from huge amounts of real-world reports. The EU-ADR Web Platform was built to further facilitate accessing, monitoring and exploring these data, enabling an in-depth analysis of adverse drug reactions risks.METHODS: The EU-ADR Web Platform exploits the wealth of data collected within a large-scale European initiative, the EU-ADR project. Millions of electronic health records, provided by national health agencies, are mined for specific drug events, which are correlated with literature, protein and pathway data, resulting in a rich drug-event dataset. Next, advanced distributed computing methods are tailored to coordinate the execution of data-mining and statistical analysis tasks. This permits obtaining a ranked drug-event list, removing spurious entries and highlighting relationships with high risk potential.RESULTS: The EU-ADR Web Platform is an open workspace for the integrated analysis of pharmacovigilance datasets. Using this software, researchers can access a variety of tools provided by distinct partners in a single centralized environment. Besides performing standalone drug-event assessments, they can also control the pipeline for an improved batch analysis of custom datasets. Drug-event pairs can be substantiated and statistically analysed within the platform's innovative working environment.CONCLUSIONS: A pioneering workspace that helps in explaining the biological path of adverse drug reactions was developed within the EU-ADR project consortium. This tool, targeted at the pharmacovigilance community, is available online at https://bioinformatics.ua.pt/euadr/. Copyright © 2012 John Wiley & Sons, Ltd.

Videojuegos como un entorno de aprendizaje: el caso de "Monturiol el joc"

Video games in a learning environ-ment and their application to the educational world has become a common study between researchers because the use of videogames in the classroom is coherent with a compe-tence-based education theory. A social science approach to video-games allows an exhaustive under-standing of the video games and of the game experience in the classroom. When a video game gives to the user a high level of immersion, all his interest and energy is focused in the game, this fact together with the motivation in the video game is the basis of interest for educators and researchers in the potentiality of the video games as learning environ-ments. In this presentation, we will show and analyze the importance of the video games in an educational context, using a case study: the video game "Monturiol el joc". In the paper, we describe the video game structure, the instructional function, the practice application and the future work. Also, we discuss the impor-tance of the video games as a learning immersive environment, and we conclude our report with a brief analysis of the importance of the study of video games.

Creation and Validation of Chronojump-Boscosystem: A Free Tool to Measure Vertical Jumps

Measuring the height of the vertical jump is an indicator of the strength and power of the lower body. The technological tools available to measure the vertical jump are black boxes and are not open to third-party verification or adaptation. We propose the creation of a measurement system called Chronojump-Boscosystem, consisting of open hardware and free software. Methods: A microcontroller was created and validated using a square wave generator and an oscilloscope. Two types of contact platforms were developed using different materials. These platforms were validated by the minimum pressure required for activation at different points by a strain gauge, together with the on/off time of our platforms in respect of the Ergojump-Boscosystem platform by a sample of 8 subjects performing submaximal jumps with one foot on each platform. Agile methodologies were used to develop and validate the software. Results: All the tools fall under the free software / open hardware guidelines and are, in that sense, free. The microcontroller margin of error is 0.1%. The validity of the fiberglass platform is 0.95 (ICC). The management software contains nearly 113.000 lines of code and is available in 7 languages.

Contenidos de aprendizaje para estudiantes de diseño en podcast

La Universitat Politècnica de Catalunya, a través del Graduado Superior de Diseño, ha realizado una experiencia en donde los contenidos de aprendizaje se han distribuido mediante podcast. Es el primer curso de diseño en esta universidad que distribuye materiales de formación con estas características, persiguiendo el objetivo de proporcionar a los estudiantes un acceso a contenidos educativos mediante un dispositivo móvil. Para evaluar esta experiencia, hemos analizado las respuestas obtenidas de los estudiantes, mediante un cuestionario. Nos encontramos con que dan un valor al Podcast como vehículo de revisión de contenidos, pero se valora más como una alternativa al aprendizaje. Los podcast crecen en cuanto a popularidad, y se han puesto a disposición de los alumnos esta tecnología considerando este reclamo y no la tecnología en sí. Con este artículo, planteamos que el podcasting ofrece a las Universidades nuevas posibilidades educacionales para llegar a más estudiantes y ofrecer otro medio de aprendizaje. Además, no solo se planteo recopilar estadísticas sobre las descargas a través de este experimento, si no también conocer las reflexiones de los estudiantes sobre la tecnología utilizada.

The Effect of a Physical Activity Program on the Total Number of Primary Care Visits in Inactive Patients: A 15-Month Randomized Controlled Trial

Abstract Background: Effective promotion of exercise could result in substantial savings in healthcare cost expenses in terms of direct medical costs, such as the number of medical appointments. However, this is hampered by our limited knowledge of how to achieve sustained increases in physical activity. Objectives: To assess the effectiveness of a Primary Health Care (PHC) based physical activity program in reducing the total number of visits to the healthcare center among inactive patients, over a 15-month period. Research Design: Randomized controlled trial. Subjects: Three hundred and sixty-two (n = 362) inactive patients suffering from at least one chronic condition were included. One hundred and eighty-three patients (n = 183; mean (SD); 68.3 (8.8) years; 118 women) were randomly allocated to the physical activity program (IG). One hundred and seventy-nine patients (n = 179; 67.2 (9.1) years; 106 women) were allocated to the control group (CG). The IG went through a three-month standardized physical activity program led by physical activity specialists and linked to community resources. Measures: The total number of medical appointments to the PHC, during twelve months before and after the program, was registered. Self-reported health status (SF-12 version 2) was assessed at baseline (month 0), at the end of the intervention (month 3), and at 12 months follow-up after the end of the intervention (month 15). Results: The IG had a significantly reduced number of visits during the 12 months after the intervention: 14.8 (8.5). The CG remained about the same: 18.2 (11.1) (P = .002). Conclusions: Our findings indicate that a 3-month physical activity program linked to community resources is a shortduration, effective and sustainable intervention in inactive patients to decrease rates of PHC visits. Trial Registration: ClinicalTrials.gov NCT00714831