3 resultados para Witsius, Herman, 1636-1708.
Resumo:
O autor, depois de fazer uma rápida revisão dos conhecimentos alcançados pela Medicina até 1900, ano em que Eça de Queiroz morreu em Paris, analisa as doenças que afligiram o escritor ao longo da sua vida, com especial destaque para aquela que o vitimou, e refere-se aos vários médicos que o trataram. Numa segunda parte, faz a revisão dos personagens-médicos presentes nos livros que escreveu, alguns dos quais desempenham um papel fundamental na estrutura da sua obra literária.
Resumo:
The last Crypto-Jews (Marranos) are the survivors of Spanish Jews who were persecuted in the late fifteenth century, escaped to Portugal and were forced to convert to save their lives. Isolated groups still exist in mountainous areas such as Belmonte in the Beira-Baixa province of Portugal. We report here the genetic study of a highly consanguineous endogamic population of Crypto-Jews of Belmonte affected with autosomal recessive retinitis pigmentosa (RP). A genome-wide search for homozygosity allowed us to localize the disease gene to chromosome 15q22-q24 (Zmax=2.95 at θ=0 at the D15S131 locus). Interestingly, the photoreceptor cell-specific nuclear receptor (PNR) gene, the expression of which is restricted to the outer nuclear layer of retinal photoreceptor cells, was found to map to the YAC contig encompassing the disease locus. A search for mutations allowed us to ascribe the RP of Crypto-Jews of Belmonte to a homozygous missense mutation in the PNR gene. Preliminary haplotype studies support the view that this mutation is relatively ancient but probably occurred after the population settled in Belmonte.
Resumo:
We studied a group of 174 Portuguese children (aged 2 mo-16 y) who mostly traveled to tropical Portuguese-speaking countries and found an attack rate of 21.8% for travelers' diarrhea, much lower than previously described. We also showed that African rate analysis by region may hide significant differences between countries.