1 resultado para Quality Regulation by Consumer Self—help
Filtro por publicador
- KUPS-Datenbank - Universität zu Köln - Kölner UniversitätsPublikationsServer (1)
- Abertay Research Collections - Abertay University’s repository (1)
- Academic Archive On-line (Jönköping University; Sweden) (1)
- Academic Research Repository at Institute of Developing Economies (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (12)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (10)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (20)
- Aston University Research Archive (17)
- Avian Conservation and Ecology - Eletronic Cientific Hournal - Écologie et conservation des oiseaux: (1)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca de Teses e Dissertações da USP (2)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (10)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (42)
- Biblioteca Virtual del Sistema Sanitario Público de Andalucía (BV-SSPA), Junta de Andalucía. Consejería de Salud y Bienestar Social, Spain (5)
- Biodiversity Heritage Library, United States (1)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (40)
- Brock University, Canada (3)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- CentAUR: Central Archive University of Reading - UK (26)
- Central European University - Research Support Scheme (1)
- CiencIPCA - Instituto Politécnico do Cávado e do Ave, Portugal (1)
- Cochin University of Science & Technology (CUSAT), India (6)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (1)
- Consorci de Serveis Universitaris de Catalunya (CSUC), Spain (52)
- Cor-Ciencia - Acuerdo de Bibliotecas Universitarias de Córdoba (ABUC), Argentina (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- Dalarna University College Electronic Archive (2)
- Digital Archives@Colby (1)
- Digital Commons - Michigan Tech (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (5)
- Digital Peer Publishing (2)
- DigitalCommons@The Texas Medical Center (19)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (40)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (1)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- Greenwich Academic Literature Archive - UK (1)
- Institute of Public Health in Ireland, Ireland (3)
- Institutional Repository of Leibniz University Hannover (2)
- Instituto Politécnico de Bragança (1)
- Instituto Politécnico de Leiria (1)
- Instituto Politécnico do Porto, Portugal (13)
- Instituto Superior de Psicologia Aplicada - Lisboa (1)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (4)
- Martin Luther Universitat Halle Wittenberg, Germany (2)
- Ministerio de Cultura, Spain (1)
- National Center for Biotechnology Information - NCBI (71)
- Open Access Repository of Indian Theses (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (4)
- Portal do Conhecimento - Ministerio do Ensino Superior Ciencia e Inovacao, Cape Verde (1)
- Publishing Network for Geoscientific & Environmental Data (9)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (1)
- RepoCLACAI - Consorcio Latinoamericano Contra el Aborto Inseguro (1)
- Repositorio Académico de la Universidad Nacional de Costa Rica (1)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (1)
- Repositório Científico da Universidade de Évora - Portugal (2)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (5)
- Repositório da Produção Científica e Intelectual da Unicamp (3)
- Repositório da Universidade Federal do Espírito Santo (UFES), Brazil (2)
- Repositório digital da Fundação Getúlio Vargas - FGV (13)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (1)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (2)
- Repositório Institucional da Universidade Tecnológica Federal do Paraná (RIUT) (1)
- Repositorio Institucional de la Universidad de Málaga (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (85)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (12)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (1)
- School of Medicine, Washington University, United States (1)
- Scielo Saúde Pública - SP (57)
- Scottish Institute for Research in Economics (SIRE) (SIRE), United Kingdom (1)
- SerWisS - Server für Wissenschaftliche Schriften der Fachhochschule Hannover (1)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (9)
- Universidad Politécnica de Madrid (17)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade do Minho (9)
- Universidade dos Açores - Portugal (3)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (2)
- Universidade Federal de Uberlândia (1)
- Universidade Federal do Pará (6)
- Universidade Federal do Rio Grande do Norte (UFRN) (17)
- Universidade Metodista de São Paulo (3)
- Universidade Técnica de Lisboa (2)
- Universita di Parma (1)
- Universitat de Girona, Spain (3)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (2)
- Université de Lausanne, Switzerland (148)
- Université de Montréal (3)
- Université de Montréal, Canada (23)
- University of Michigan (8)
- University of Queensland eSpace - Australia (43)
- University of Washington (1)
Resumo:
Abstract In a few rare diseases, specialised studies in cerebrospinal fluid (CSF) are required to identify the underlying metabolic disorder. We aimed to explore the possibility of detecting key synaptic proteins in the CSF, in particular dopaminergic and gabaergic, as new procedures that could be useful for both pathophysiological and diagnostic purposes in investigation of inherited disorders of neurotransmission. Dopamine receptor type 2 (D2R), dopamine transporter (DAT) and vesicular monoamine transporter type 2 (VMAT2) were analysed in CSF samplesfrom 30 healthy controls (11 days to 17 years) by western blot analysis. Because VMAT2 was the only protein with intracellular localisation, and in order to compare results, GABA vesicular transporter, which is another intracellular protein, was also studied. Spearman’s correlation and Student’s t tests were applied to compare optical density signals between different proteins. All these synaptic proteins could be easily detected and quantified in the CSF. DAT, D2R and GABA VT expression decrease with age, particularly in the first months of life, reflecting the expected intense synaptic activity and neuronal circuitry formation. A statistically significant relationship was found between D2R and DAT expression, reinforcing the previous evidence of DAT regulation by D2R. To our knowledge, there are no previous studies on human CSF reporting a reliable analysis of these proteins. These kinds of studies could help elucidate new causes of disturbed dopaminergic and gabaergic transmission as well as understanding different responses to L-dopa in inherited disorders affecting dopamine metabolism. Moreover, this approach to synaptic activity in vivo can be extended to different groups of proteins and diseases.