Chemical reaction network of flavylium ions in heterogeneous media

Dissertação apresentada para a obtenção do Grau de Doutor em Química, especialidade em Química-Física, pela Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia

Visualization of clusters in geo-referenced data using three-dimensional self-organizing maps

Dissertação apresentada como requisito parcial para obtenção do grau de Mestre em Estatística e Gestão de Informação

trans-Acting factors and cis elements involved in glucose repression of arabinan degradation in Bacillus subtilis.

Journal of Bacteriology (Nov 2007) 8371-8376

Design of New Materials for Passive Vibration Control

The objective of this contribution is to extend the models of cellular/composite material design to nonlinear material behaviour and apply them for design of materials for passive vibration control. As a first step a computational tool allowing determination of optimised one-dimensional isolator behaviour was developed. This model can serve as a representation for idealised macroscopic behaviour. Optimal isolator behaviour to a given set of loads is obtained by generic probabilistic metaalgorithm, simulated annealing. Cost functional involves minimization of maximum response amplitude in a set of predefined time intervals and maximization of total energy absorbed in the first loop. Dependence of the global optimum on several combinations of leading parameters of the simulated annealing procedure, like neighbourhood definition and annealing schedule, is also studied and analyzed. Obtained results facilitate the design of elastomeric cellular materials with improved behaviour in terms of dynamic stiffness for passive vibration control.

Multy-dimensional composition by objectives in aspect-oriented requirements analysis

Thesis submitted to Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa in partial fulfilment of the requirements for the degree of Master in Computer Science

Famílias de pessoas com síndromes psicóticas : análise dimensional e avaliação da efectividade de uma intervenção em grupos para familiares

RESUMO:Enquadramento teórico Nas famílias das pessoas com síndromas psicóticas, a história natural da prestação de cuidados informais é ainda pouco conhecida. Independentemente disso, o impacto sobre os cuidadores tem sido alvo de intervenções familiares (IF) psicoeducativas. Não esquecendo que contextos clínicos diferentes, como é o caso das demências, exibem, nas famílias, especificidades a explorar, torna-se crucial aperfeiçoar métodos para avaliação de grupos de risco e estudo da efectividade das IF. As intervenções em grupos para familiares (IGF) são exequíveis e cobrem parte das necessidades das famílias. Ao invés de outras IF, falta evidência inequívoca de que as IGF influenciem o prognóstico da esquizofrenia (diminuindo as taxas de recaída ou melhorando o funcionamento dos doentes). Em Portugal, são praticamente inexistentes dados sobre avaliação de IGF. O estudo FAPS (FAmílias de Pessoas com PSicose) teve como objectivos: estudar a adesão a uma IGF, avaliar a efectividade desta e estudar prospectivamente uma coorte de familiares que não tivessem aderido (considerando dimensões da experiência de cuidar e preditores putativos: suporte social, coping, sentido de coerência-SOC, covariáveis clínico-funcionais do doente). Adicionalmente, intentou a validação do Involvement Evaluation Questionnaire, versão europeia (IEQ-EU), numa população portuguesa.

Design of New Materials for Passive Vibration Control

The aim of this contribution is to extend the techniques of composite materials design to non-linear material behaviour and apply it for design of new materials for passive vibration control. As a first step a computational tool allowing determination of macroscopic optimized one-dimensional isolator behaviour was developed. Voigt, Maxwell, standard and more complex material models can be implemented. Objective function considers minimization of the initial reaction and/or displacement peak as well as minimization of the steady-state amplitude of reaction and/or displacement. The complex stiffness approach is used to formulate the governing equations in an efficient way. Material stiffness parameters are assumed as non-linear functions of the displacement. The numerical solution is performed in the complex space. The steady-state solution in the complex space is obtained by an iterative process based on the shooting method which imposes the conditions of periodicity with respect to the known value of the period. Extension of the shooting method to the complex space is presented and verified. Non-linear behaviour of material parameters is then optimized by generic probabilistic meta-algorithm, simulated annealing. Dependence of the global optimum on several combinations of leading parameters of the simulated annealing procedure, like neighbourhood definition and annealing schedule, is also studied and analyzed. Procedure is programmed in MATLAB environment.

Geomorphic dam-break flows. Part I: conceptual model

Proceedings of the Institution of Civil Engineers - Water Management 163 Issue WM6

Caracterização do potencial citotóxico e mecanismos de acção de um complexo de platina de configuração trans em células animais

Dissertação apresentada para obtenção do Grau de Mestre em Genética Molecular e Biomedicina, pela Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia

Trans-Synaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1

Throughout the brain, patterns of activity in postsynaptic neurons influence the properties of synaptic inputs. Such feedback regulation is central to neural network stability that underlies proper information processing and feature representation in the central nervous system. At the cellular level, tight coupling of presynaptic and postsynaptic function is fundamental to neural computation and synaptic plasticity. The cohort of protein complexes at the pre and postsynaptic membrane allows for tight synapse-specific segregation and integration of diverse molecular and electrical signals.(...)

Trans Lineam/De Linea: Heidegger versus Jünger sobre o nihilismo

A finalidade da investigação é inquirir o modo como o problema do nihilismo se acha concebido no confronto entre Heidegger e Jünger. Para esse efeito, toma-se como ponto de partida dois textos: por um lado, o ensaio de Jünger intitulado Über die Linie, publicado em 1949, na Festschrift dedicada a Heidegger por ocasião dos seus sessenta anos; por outro lado, a “resposta” dada por Heidegger, em 1955, no seu contributo para uma Festschrift análoga, dedicada a Jünger – “resposta” originalmente publicada com o título Über »die Linie« (e posteriormente republicada com o título Zur Seinsfrage).

EFFECT – Efficient finite element code

The theme of this dissertation is the finite element method applied to mechanical structures. A new finite element program is developed that, besides executing different types of structural analysis, also allows the calculation of the derivatives of structural performances using the continuum method of design sensitivities analysis, with the purpose of allowing, in combination with the mathematical programming algorithms found in the commercial software MATLAB, to solve structural optimization problems. The program is called EFFECT – Efficient Finite Element Code. The object-oriented programming paradigm and specifically the C ++ programming language are used for program development. The main objective of this dissertation is to design EFFECT so that it can constitute, in this stage of development, the foundation for a program with analysis capacities similar to other open source finite element programs. In this first stage, 6 elements are implemented for linear analysis: 2-dimensional truss (Truss2D), 3-dimensional truss (Truss3D), 2-dimensional beam (Beam2D), 3-dimensional beam (Beam3D), triangular shell element (Shell3Node) and quadrilateral shell element (Shell4Node). The shell elements combine two distinct elements, one for simulating the membrane behavior and the other to simulate the plate bending behavior. The non-linear analysis capability is also developed, combining the corotational formulation with the Newton-Raphson iterative method, but at this stage is only avaiable to solve problems modeled with Beam2D elements subject to large displacements and rotations, called nonlinear geometric problems. The design sensitivity analysis capability is implemented in two elements, Truss2D and Beam2D, where are included the procedures and the analytic expressions for calculating derivatives of displacements, stress and volume performances with respect to 5 different design variables types. Finally, a set of test examples were created to validate the accuracy and consistency of the result obtained from EFFECT, by comparing them with results published in the literature or obtained with the ANSYS commercial finite element code.

Electrical characterization and modification of low dimensional oxide semiconductors for sensor applications

This work reviews the recent research on ion and UV irradiation of β-