62 resultados para Order-preserving Functions


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Glasgow Mathematical Journal, nº 47 (2005), pg. 413-424

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Semigroup Forum vol. 68 (2004), p. 335–356

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Communications in Algebra

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Algebra Colloquium, 15 (2008), p. 581–588

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Communications in Algebra, 33 (2005), p. 587-604

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Bulletin of the Malaysian Mathematical Sciences Society, 2, 34 (1),(2011), p. 79–85

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Bulletin of the Malaysian Mathematical Sciences Society

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Glasgow Mathematical Journal, nº 50 (2008), p. 325-333

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Signal Processing, vol. 86, nº 10

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Background/Aims: Unconjugated bilirubin (UCB) impairs crucial aspects of cell function and induces apoptosis in primary cultured neurones. While mechanisms of cytotoxicity begin to unfold, mitochondria appear as potential primary targets. Methods: We used electron paramagnetic resonance spectroscopy analysis of isolated rat mitochondria to test the hypothesis that UCB physically interacts with mitochondria to induce structural membrane perturbation, leading to increased permeability, and subsequent release of apoptotic factors. Results: Our data demonstrate profound changes on mitochondrial membrane properties during incubation with UCB, including modified membrane lipid polarity and fluidity (P , 0:01), as well as disrupted protein mobility(P , 0:001). Consistent with increased permeability, cytochrome c was released from the intermembrane space(P , 0:01), perhaps uncoupling the respiratory chain and further increasing oxidative stress (P , 0:01). Both ursodeoxycholate, a mitochondrial-membrane stabilising agent, and cyclosporine A, an inhibitor of the permeability transition, almost completely abrogated UCB-induced perturbation. Conclusions: UCB directly interacts with mitochondria influencing membrane lipid and protein properties, redox status, and cytochrome c content. Thus, apoptosis induced by UCB may be mediated, at least in part, by physical perturbation of the mitochondrial membrane. These novel findings should ultimately prove useful to our evolving understanding of UCB cytotoxicity.

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Fractional central differences and derivatives are studied in this article. These are generalisations to real orders of the ordinary positive (even and odd) integer order differences and derivatives, and also coincide with the well known Riesz potentials. The coherence of these definitions is studied by applying the definitions to functions with Fourier transformable functions. Some properties of these derivatives are presented and particular cases studied.

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Journal of Vibration and Control, Vol. 14, Nº 9-10

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Thesis submitted for assessment with a view to obtaining the degree of Doctor of Political and Social Science of the European University Institute

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Dissertação apresentada para obtenção do Grau de Doutor em Engenharia Electrotécnica e de Computadores pela Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia

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Journal of Vibration and Control, 14(9–10): 1255–1266, 2008