Molecular mechanisms of sexual development in basidiomycetes: exploring connections with lifestyles

Disserta����o para obten����o do Grau de Doutor em Biologia

Development of CO-releasing molecular for the treatment of inflammatory diseases

Dissertation presented to obtain a Ph.D. degree (Doutoramento) in Chemistry at the Instituto de Tecnologia Quimica e Biol6gica da Universidade Nova de Lisboa

Gold nanoparticle to antibody conjugates for diagnosis applications: molecular interactions and immunoassay development

Thesis for the Master degree in Structural and Functional Biochemistry

Molecular modulation of brain development and function: lessons from ���old��� and ���new���

Dissertation presented to obtain the Ph.D degree in Biology

An integrated approach to Physcomitrella patens transcriptomics reveals importantclues of the evolutionary development of plant organs and sexual reproduction

Land plant evolution required the generation of a new body plan that could resist the harsher and fluctuating environmental conditions found outside of aquatic environments. Unraveling the genetic basis of plant developmental innovations is not only revealing in terms of an evolutionary point of view, but it is also important for understanding the emergence of agronomically important traits. Comparative genetic studies between basal and modern land plants, both at the genome and trancriptome levels, can help in the generation of hypotheses related to the genetic basis of plant evolutionary development.(...)

Development of polymeric membranes for forward osmosis

Disserta����o apresentada na Faculdade de Ci��ncias e Tecnologia da Universidade Nova de Lisboa para obten����o do grau de Mestre em Engenharia Qu��mica e Bioqu��mica

Development of molecularly imprinted polymers using supercritical fluid technology

Disserta����o para obten����o do Grau de Doutor em Qu��mica Sustent��vel

Dissecting neuronal development deficits by inflammation: from morphology to cytoskeleton dynamics

Disserta����o para obten����o do Grau de Mestre em Gen��tica Molecular e Biomedicina

Ditopic molecular architectures for the recognition of anionic species

Dissertation presented to obtain the Ph.D degree in Chemistry

Unveiling the mating system and genetic variability in the yeast Kwoniella mangroviensis using molecular approaches

Disserta����o para obten����o do Grau de Mestre em Gen��tica Molecular e Biomedicina

Development of novel human cellular models for neurotoxicity studies

Dissertation to obtain master degree in Gen��tica Molecular e Biomedicina

Medicago truncatula as a platform for Molecular Farming: a study of the subcellular localization of a human recombinant protein!

Dissertation presented at Faculdade de Ci��ncias e Tecnologia of Universidade Nova de Lisboa to obtain the Degree of Master in Biotecnology

Molecular tools to dissect the role of Dmrt2a and Dmrt2b in the left-right axis formation in zebrafish

Disserta����o para obten����o do Grau de Mestre em Gen��tica Molecular e Biomedicina

Role of Notch signaling on the differentiation of early lymphoid progenitors cells: a view throughout the development of the embryonic chicken thymus and spleen

Disserta����o para a obten����o do grau de Mestre em Gen��tica Molecular e Biomedicina

Influence of the molecular weight in mechanical properties and degradation kinetics of chitosan inverted colloidal crystals

Tissue engineering arises from the need to regenerate organs and tissues, requiring the development of scaffolds, which can provide an optimum environment for tissue growth. In this work, chitosan with different molecular weights was used to develop biodegradable 3D inverted colloidal crystals (ICC) structures for bone regeneration, exhibiting uniform pore size and interconnected network. Moreover, in vitro tests were conducted by studying the influence of the molecular weight in the degradation kinetics and mechanical properties. The production of ICC included four major stages: fabrication of microspheres; assembly into a cohesive structure, polymeric solution infiltration and microsphere removal. Chitosan���s degree of deacetylation was determined by infrared spectroscopy and molecular weight was obtained via capillary viscometry. In order to understand the effect of the molecular weight in ICC structures, the mass loss and mechanical properties were analyzed after degradation with lysozyme. Structure morphology observation before and after degradation was performed by scanning electron microscopy. Cellular adhesion and proliferation tests were carried out to evaluate ICC in vitro response. Overall, medium molecular weight ICC revealed the best balance in terms of mechanical properties, degradation rate, morphology and biological behaviour.