A private library in the Mateus Palace (Vila Real). The D. Luís António de Sousa Botelho Mourão (1722-1798) Books Collection

Fundação para a Ciência e Tecnologia no âmbito de Bolsa de Doutoramento (SFRH/BD/86280/2012)

Traceability support in software product lines

Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para a obtenção do grau de Mestre em Engenharia Informática.

Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production

ABSTRACT – Background: According to the Report on Carcinogens, formaldehyde ranks 25th in the overall U.S. chemical production, with more than 5 million tons produced each year. Given its economic importance and widespread use, many people are exposed to formaldehyde environmentally and/or occupationally. Presently, the International Agency for Research on Cancer classifies formaldehyde as carcinogenic to humans (Group 1), based on sufficient evidence in humans and in experimental animals. Manyfold in vitro studies clearly indicated that formaldehyde can induce genotoxic effects in proliferating cultured mammalian cells. Furthermore, some in vivo studies have found changes in epithelial cells and in peripheral blood lymphocytes related to formaldehyde exposure. Methods: A study was carried out in Portugal, using 80 workers occupationally exposed to formaldehyde vapours: 30 workers from formaldehyde and formaldehyde-based resins production factory and 50 from 10 pathology and anatomy laboratories. A control group of 85 non-exposed subjects was considered. Exposure assessment was performed by applying simultaneously two techniques of air monitoring: NIOSH Method 2541 and Photo Ionization Detection equipment with simultaneously video recording. Evaluation of genotoxic effects was performed by application of micronucleus test in exfoliated epithelial cells from buccal mucosa and peripheral blood lymphocytes. Results: Time-weighted average concentrations not exceeded the reference value (0.75 ppm) in the two occupational settings studied. Ceiling concentrations, on the other hand, were higher than reference value (0.3 ppm) in both. The frequency of micronucleus in peripheral blood lymphocytes and in epithelial cells was significantly higher in both exposed groups than in the control group (p < 0.001). Moreover, the frequency of micronucleus in peripheral blood lymphocytes was significantly higher in the laboratories group than in the factory workers (p < 0.05). A moderate positive correlation was found between duration of occupational exposure to formaldehyde (years of exposure) and micronucleus frequency in peripheral blood lymphocytes (r = 0.401; p < 0.001) and in epithelial cells (r = 0.209; p < 0.01). Conclusions: The population studied is exposed to high peak concentrations of formaldehyde with a long-term exposure. These two aspects, cumulatively, can be the cause of the observed genotoxic endpoint effects. The association of these cytogenetic effects with formaldehyde exposure gives important information to risk assessment process and may also be used to assess health risks for exposed worker

Shakespeare no circuito de uma epístola entre Londres e Lisboa

No decurso de um processo de investigação, deparamo-nos por vezes com algumas surpresas que, em alguns casos, vêm alterar de forma decisiva conhecimentos que tínhamos por certos. Era até há pouco tempo um facto consensualmente aceite que as primeiras referências a Shakespeare na cultura portuguesa – excepção honrosa feita ao Padre Bernardo de Lima (1762) – datavam do século XIX. Apesar da apresentação da ópera de Zingarelli em S. Carlos em 1798 (cf. Benevides, 1883 e Carvalho, 1993), Shakespeare não despertou grande interesse nos autores e tradutores portugueses antes da segunda década de oitocentos. Estudos de, entre outros, Carlos Estorninho (1964), Maria do Céu Saraiva Jorge (1951) e Jorge Bastos da Silva (2000 e 2005) repetem-no.1 No entanto, há cerca de três anos, num período de trabalho no Centro de Estudos Anglo-Portugueses, a Doutora Isabel Lousada identificou uma carta do poeta Edward Young, incluída no volume que inclui as traduções de duas peças deste autor, onde, de acordo com o cabeçalho, existe “HUM DISCURSO DO AUTHOR Sobre o Theatro Inglez, comparado com o Theatro Francez”, em que se verifica uma referência a Shakespeare. Amavelmente, e sabendo do meu interesse pela recepção da obra deste autor em Portugal, a Doutora Isabel Lousada fez-me chegar o texto às mãos. Por coincidência, no dia em que tal aconteceu, esteve no CEAP [Centro de Estudos Anglo-Portugueses]2 a Professora Maria Manuela Delille que, posta ao corrente do título da Epístula, achou de interesse que o texto fosse estudado. É por isso que julgamos pertinente, agora que se pretende um volume de homenagem à Professora, apresentar em co-autoria uma primeira abordagem ao trabalho que então discutimos.

Na rota dos albatrozes : Lowry leitor de Coleridge

Actas do XIX encontro da Associação Portuguesa de Estudos Anglo-Americanos - APEAA (Sintra 1-3 de Abril, 1998)