Porto: cidade amiga das pessoas idosas: um estudo centrado na visão de prestadores de serviços a pessoas idosas das freguesias de Cedofeita, Paranhos, St. Ildefonso, Bonfim e Campanhã

O envelhecimento da população é um fenómeno das sociedades contemporâneas simultâneo à crescente modificação do meio urbano. De modo a responder a estas alterações a Organização Mundial de Saúde (OMS) lançou o projeto Cidade Amiga das Pessoas Idosas que preconiza a adaptação das estruturas e serviços para que estes sejam acessíveis e promovam a inclusão dos cidadãos idosos. A presente investigação, de natureza qualitativa e exploratória, tem como objetivo verificar se a cidade do Porto possui características de uma cidade amiga das pessoas idosas através da visão de prestadores de serviços a pessoas idosas das freguesias de Paranhos, Cedofeita, St. Ildefonso, Bonfim e Campanhã. Pretende, assim, ser um contributo para o desenvolvimento do projeto Cidade Amiga das Pessoas Idosas na cidade portuense. Para tal, realizam-se 3 focus groups com prestadores de serviços selecionados a partir de uma amostragem por conveniência, onde se utiliza um guião de entrevista semi-estruturado com as seguintes categorias: espaços exteriores e edifícios, transportes, habitação, participação social, respeito e inclusão social, participação cívica e emprego, comunicação e informação e apoio comunitário e serviços de saúde. É possível verificar que os participantes partilham, de forma geral, uma imagem positiva da cidade do Porto, contudo, têm tendência a iniciar o discurso pelas características negativas da cidade. Colaboram também com sugestões de melhoria para a cidade. Pela perspetiva dos participantes é possível verificar que aspetos relacionados com espaços exteriores e edifícios, respeito e inclusão social e apoio comunitário e serviços de saúde se destacam pela negativa, enquanto aspetos intimos à participação social das pessoas idosas bem como, à comunicação e informação na cidade do Porto são na generalidade elogiados. Desta forma, indicam como positivo o aparecimento de novas iniciativas como as Universidades Seniores ou o projeto “Afetos” desenvolvido pela Misericórdia; as ofertas dirigidas à população sénior desenvolvidas pelas Juntas de Freguesia e a presença de jornais de distribuição gratuita, em espaços públicos. Por oposição, identificam como pouco amigo das pessoas idosas os passeios pouco largos, com obstáculos e pouco cuidados; a falta de casas de banho públicas; o desinvestimento em atividades intergeracionais e a carência de lares públicos na cidade.

Monitoring of ochratoxin a exposure of the Portuguese population through a nationwide urine survey — winter 2007

Ochratoxin A (OTA) is a mycotoxin produced by a variety of fungi, such as Penicillium verrucosum and Aspergillium spp., which has been found to have a wide number of potentially deadly toxic effects, and can enter the human organism through a variety of means. It then finds its way into the bloodstream and, after a lengthy process, is eventually excreted through the urine. It can thus be detected in its original form not only in blood samples but also in this biological medium. As such, and in an attempt to evaluate the exposure of the Portuguese population to this mycotoxin, morning urine samples were collected during the Winter of 2007, from each of five geographically distinct Portuguese locations — Bragança, Porto, Coimbra, Alentejo, and Algarve — and subjected to extraction by immunoaffinity columns and to OTA quantification through liquid chromatography coupled with fluorescence detection. Prevalent incidence was higher than 95% with Coimbra being the exception (incidence of 73.3%). In nearly all locations, the OTA content of most samples was found to be above the limit of quantification (LOQ) of 0.008 ng/ml. Indeed, excluding Coimbra, with an OTA content level of 0.014 ng/ml, all regions featured content values over 0.021 ng/ml.

The role of functional polymorphisms in immune response genes as biomarkers of BCG Immunotherapy outcome in bladder cancer: Establishment of a predictive profile in a Southern Europe population

OBJECTIVE: To evaluate the predictive value of genetic polymorphisms in the context of BCG immunotherapy outcome and create a predictive profile that may allow discriminating the risk of recurrence. MATERIAL AND METHODS: In a dataset of 204 patients treated with BCG, we evaluate 42 genetic polymorphisms in 38 genes involved in the BCG mechanism of action, using Sequenom MassARRAY technology. Stepwise multivariate Cox Regression was used for data mining. RESULTS: In agreement with previous studies we observed that gender, age, tumor multiplicity and treatment scheme were associated with BCG failure. Using stepwise multivariate Cox Regression analysis we propose the first predictive profile of BCG immunotherapy outcome and a risk score based on polymorphisms in immune system molecules (SNPs in TNFA-1031T/C (rs1799964), IL2RA rs2104286 T/C, IL17A-197G/A (rs2275913), IL17RA-809A/G (rs4819554), IL18R1 rs3771171 T/C, ICAM1 K469E (rs5498), FASL-844T/C (rs763110) and TRAILR1-397T/G (rs79037040) in association with clinicopathological variables. This risk score allows the categorization of patients into risk groups: patients within the Low Risk group have a 90% chance of successful treatment, whereas patients in the High Risk group present 75% chance of recurrence after BCG treatment. CONCLUSION: We have established the first predictive score of BCG immunotherapy outcome combining clinicopathological characteristics and a panel of genetic polymorphisms. Further studies using an independent cohort are warranted. Moreover, the inclusion of other biomarkers may help to improve the proposed model.

Desenvolvimento de código pictográfico para identificação de medicamentos

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Osteoporotic hip fractures: Bisphosphonates sales and observed turning point in trend. A population-based retrospective study

The aim is to examine the temporal trends of hip fracture incidence in Portugal by sex and age groups, and explore the relation with anti-osteoporotic medication. From the National Hospital Discharge Database, we selected from 1st January 2000 to 31st December 2008, 77,083 hospital admissions (77.4% women) caused by osteoporotic hip fractures (low energy, patients over 49 years-age), with diagnosis codes 820.x of ICD 9-CM. The 2001 Portuguese population was used as standard to calculate direct age-standardized incidence rates (ASIR) (100,000 inhabitants). Generalized additive and linear models were used to evaluate and quantify temporal trends of age specific rates (AR), by sex. We identified 2003 as a turning point in the trend of ASIR of hip fractures in women. After 2003, the ASIR in women decreased on average by 10.3 cases/100,000 inhabitants, 95% CI (− 15.7 to − 4.8), per 100,000 anti-osteoporotic medication packages sold. For women aged 65–69 and 75–79 we identified the same turning point. However, for women aged over 80, the year 2004 marked a change in the trend, from an increase to a decrease. Among the population aged 70–74 a linear decrease of incidence rate (95% CI) was observed in both sexes, higher for women: − 28.0% (− 36.2 to − 19.5) change vs − 18.8%, (− 32.6 to − 2.3). The abrupt turning point in the trend of ASIR of hip fractures in women is compatible with an intervention, such as a medication. The trends were different according to gender and age group, but compatible with the pattern of bisphosphonates sales.