Uma metaheurística para a programação de projectos com multi-modos e recursos limitados

Este artigo apresenta uma nova abordagem (MM-GAV-FBI), aplicável ao problema da programação de projectos com restrições de recursos e vários modos de execução por actividade, problema conhecido na literatura anglo-saxónica por MRCPSP. Cada projecto tem um conjunto de actividades com precedências tecnológicas definidas e um conjunto de recursos limitados, sendo que cada actividade pode ter mais do que um modo de realização. A programação dos projectos é realizada com recurso a um esquema de geração de planos (do inglês Schedule Generation Scheme - SGS) integrado com uma metaheurística. A metaheurística é baseada no paradigma dos algoritmos genéticos. As prioridades das actividades são obtidas a partir de um algoritmo genético. A representação cromossómica utilizada baseia-se em chaves aleatórias. O SGS gera planos não-atrasados. Após a obtenção de uma solução é aplicada uma melhoria local. O objectivo da abordagem é encontrar o melhor plano (planning), ou seja, o plano que tenha a menor duração temporal possível, satisfazendo as precedências das actividades e as restrições de recursos. A abordagem proposta é testada num conjunto de problemas retirados da literatura da especialidade e os resultados computacionais são comparados com outras abordagens. Os resultados computacionais validam o bom desempenho da abordagem, não apenas em termos de qualidade da solução, mas também em termos de tempo útil.

Influence of crystallite size of nanophased hydroxyapatite on fibronectin and osteonectin adsorption and on MC3T3-E1 osteoblast adhesion and morphology

The characteristic topographical features (crystallite dimensions, surface morphology and roughness) of bioceramics may influence the adsorption of proteins relevant to bone regeneration. This work aims at analyzing the influence of two distinct nanophased hydroxyapatite (HA) ceramics, HA725 and HA1000 on fibronectin (FN) and osteonectin (ON) adsorption and MC3T3-E1 osteoblast adhesion and morphology. Both substrates were obtained using the same hydroxyapatite nanocrystals aggregates and applying the sintering temperatures of 725ºC and 1000ºC, respectively. The two proteins used in this work, FN as an adhesive glycoprotein and ON as a counter-adhesive protein, are known to be involved in the early stages of osteogenesis (cell adhesion, mobility and proliferation). The properties of the nanoHA substrates had an important role in the adsorption behavior of the two studied proteins and clearly affected the MC3T3- E1 morphology, distribution and metabolic activity. HA1000 surfaces presenting slightly larger grain size, higher root-mean-square roughness (Rq), lower surface area and porosity, allowed for higher amounts of both proteins adsorbed. These substrates also revealed increased number of exposed FN cell-binding domains as well as higher affinity for osteonectin. Regarding the osteoblast adhesion results, improved viability and cell number were found for HA1000 surfaces as compared to HA725 ones, independently of the presence or type of adsorbed protein. Therefore the osteoblast adhesion and metabolic activity seemed to be more sensitive to surfaces morphology and roughness than to the type of adsorbed proteins.

Size matters when we talk about corporate social responsibility: the case of portuguese companies

Social responsibility arises as a measure of the corporate policy that goes beyond the production activity, thus covering also the social and environmental activities. This issue has been gaining importance over time. The number of companies that are implementing socially responsible actions has been growing steadily even though it is still centered on large and medium sized companies. Social responsibility is an accessible theme to any company of any size, once the social and environmental issues are resolved through concrete actions, but in the small and micro-sized companies there are factors that inhibit such actions. Some of these factors are: reduced investment capacity; minimal expectations of medium to long term returns; or even the short-term management focus that is aimed at survival. Such facts can be verified in the case of Portuguese companies, where out of the 41 companies certified by SA 8000 only 5 are micro-sized or small and even these are linked to large organizations.