Influence of computed tomography attenuation correction in myocardial perfusion imaging in obese population

Marked regional variations in myocardial activity that are not related to myocardial perfusion defects.Verify the influence of CT-AC inMPI results in patients with BMI between 30 and 35 and higher than 30 for male and female population.

Radiopharmaceuticals for myocardial perfusion imaging: SPECT & PET

Myocardial perfusion imaging (MPI) is used on a daily basis to access coronary blood flow in patients that are suspected or have known Coronary Artery Disease (CAD). A Single Photon Emission Computed Tomography (SPECT) or and Positron Emission Tomography (PET) scan are used to access regional blood flow quantification either at rest or stress, the imaging acquisition is connected to an Electrocardiogram (ECG) and it is able to determine and quantify other myocardial parameters like myocardial wall thickness and wall motion. PET is not used so broadly due to its high procedure cost, the proximity with cyclotron, where are produced the majority of radiopharmaceuticals used in PET, due to their shor thalf-life. This work is intended to carry out a review of the tests relating to radiopharmaceuticals that are used in clinical practice in SPECT or PET for assessment of myocardial perfusion, also focusing very promising radiopharmaceuticals that are under investigation or in clinical trials with great potential for conventional nuclear medicine or PET, proceeding to a comparative analysis of both techniques and respective radiopharmaceuticals used.

Optimização da afectação de recursos à produção de serviços da CP regional

O investimento efectuado na últimas décadas, em Portugal, nas infra-estruturas de transporte de longa duração, permitiu o desenvolvimento da rede rodoviária, quer em extensão quer em qualidade, enquanto pelo contrário, a Rede Ferroviária Nacional (RFN), entrou num processo contínuo de degradação, percebido pela redução das velocidades máximas permitidas e pelo elevado número e dispersão de limitações (reduções) de velocidades impostas na via-férrea. Actualmente, um comboio ao circular na RFN, fica sujeito a variadíssimas reduções de velocidade, recorrendo obrigatoriamente à utilização do freio, com impacto na eficiência energética e na redução das velocidades comerciais. Estes factores, associados às baixas performances do material, nomeadamente o reduzido esforço acelerador, em particular no diesel, resulta no aumento dos tempos de percurso e na redução do conforto, factores que constituem sem dúvida, as principais causas de perda de competitividade do sector ferroviário, tendo culminado na perda de 30% dos passageiros transportados, para o modo rodoviário, nas últimas décadas. Constituiu o objectivo deste trabalho, criar um modelo dinâmico, que permita identificar os pontos críticos da RFN, medindo o impacto das reduções de velocidade nas circulações ferroviárias, em tempo perdido, em termos energéticos, ambientais e financeiros. Os indicadores obtidos através da aplicação do modelo, são produzidos com auxílio do computador, identificando os pontos críticos da infra-estrutura e ordenando-os em função do impacto financeiro na oferta comercial da CP regional. Este relatório, será efectuado com uma periodicidade concertada com a REFER e permitirá ao gestor da infra-estrutura, programar de forma objectiva as intervenções na RFN, eliminando os pontos críticos. Contibui-se assim, para a melhoria da qualidade do serviço, para o aumento da competitividade e da sustentabilidade do sector ferroviário em Portugal.

Image quality of myocardial perfusion-gated studies: effect of ingestion of different fat content in the reduction of extra-myocardial abdominal signal

Myocardial perfusion-gated-SPECT (MP-gated-SPECT) imaging often shows radiotracer uptake in abdominal organs. This accumulation interferes frequently with qualitative and quantitative assessment of the infero-septal region of myocardium. The objective of this study is to evaluate the effect of ingestion of different fat content on the reduction of extra-myocardial uptake and to improve MP-gated-SPECT image quality. In this study, 150 patients (65 ^ 18 years) who were referred for MP-gated-SPECT underwent a 1-day-protocol including imaging after stress (physical or pharmacological) and resting conditions. All patients gave written informed consent. Patients were subdivided into five groups: GI, GII, GIII, GIV and GV. In the first four groups, patients ate two chocolate bars with different fat content. Patients in GV – control group (CG) – had just water. Uptake indices (UI) of myocardium (M)/liver(L) and M/stomach–proximal bowel(S) revealed lower UI of M/S at rest in all groups. Both stress and rest studies using different food intake indicate that patients who ate chocolate with different fat content showed better UI of M/L than the CG. The UI of M/L and M/S of groups obtained under physical stress are clearly superior to that of groups obtained under pharmacological stress. These differences are only significant in patients who ate high-fat chocolate or drank water. The analysis of all stress studies together (GI, GII, GIII and GIV) in comparison with CG shows higher mean ranks of UI of M/L for those who ate high-fat chocolate. After pharmacological stress, the mean ranks of UI of M/L were higher for patients who ate high- and low-fat chocolate. In conclusion, eating food with fat content after radiotracer injection increases, respectively, the UI of M/L after stress and rest in MP-gated-SPECT studies. It is, therefore, recommended that patients eat a chocolate bar after radiotracer injection and before image acquisition.

O controlo de gestão nas instituições financeiras e a aplicabilidade do balanced scorecard numa instituição financeira a nível regional

Mestrado em Contabilidade e Gestão das Instituições Financeiras

Imprensa regional desportiva: jornal Tribuna Desportiva e o sentimento de pertença à comunidade de abrangência

Dissertação apresentada à Escola Superior de Comunicação Social como parte dos requisitos para obtenção de grau de mestre em Jornalismo.

A imprensa regional e local: estudo de caso do jornal O Ribatejo

Dissertação apresentada à Escola Superior de Comunicação Social como parte dos requisitos para obtenção de grau de mestre em Jornalismo.

Critérios que definem a agenda e o alinhamento noticioso de um canal regional: estudo de caso da localvisão TV

Relatório de estágio apresentado à Escola Superior de Comunicação Social como parte dos requisitos para obtenção de grau de mestre em Jornalismo.

A motivação da aprendizagem de um instrumento musical em alunos do ensino básico articulado sob a perspectiva da teoria da auto-determinação no Conservatório Regional de Setúbal: relatório de estágio

O presente relatório, no âmbito da obtenção do grau de Mestre no Ensino da Música, na Escola Superior de Música de Lisboa, descreve o estágio efectuado no Conservatório Regional de Setúbal e analisa a prática pedagógica do professor através de três alunos de violino e viola d´arco de níveis diferentes: Iniciação (violino); 4º grau, Ensino Básico (viola d´arco) e 7º grau, Ensino Secundário (viola d´arco). São descritas e analisadas as práticas pedagógicas desenvolvidas com base na filosofia do Método Suzuki e na Teoria da Auto-­determinação de Edward L. Deci e Richard M. Ryan. O objectivo fundamental do processo de ensino-­ aprendizagem é a criação de condições para que os alunos se motivem autonomamente e atinjam níveis altos de motivação intrínseca (Teoria da Auto-­determinação), e que se tornem bons instrumentistas e melhores seres humanos (Método Suzuki).

Moisture recycling in the Iberian Peninsula from a regional climate simulation: spatiotemporal analysis and impact on the precipitation regime

The contribution of the evapotranspiration from a certain region to the precipitation over the same area is referred to as water recycling. In this paper, we explore the spatiotemporal links between the recycling mechanism and the Iberian rainfall regime. We use a 9 km resolution Weather Research and Forecasting simulation of 18 years (1990-2007) to compute local and regional recycling ratios over Iberia, at the monthly scale, through both an analytical and a numerical recycling model. In contrast to coastal areas, the interior of Iberia experiences a relative maximum of precipitation in spring, suggesting a prominent role of land-atmosphere interactions on the inland precipitation regime during this period of the year. Local recycling ratios are the highest in spring and early summer, coinciding with those areas where this spring peak of rainfall represents the absolute maximum in the annual cycle. This confirms that recycling processes are crucial to explain the Iberian spring precipitation, particularly over the eastern and northeastern sectors. Average monthly recycling values range from 0.04 in December to 0.14 in June according to the numerical model and from 0.03 in December to 0.07 in May according to the analytical procedure. Our analysis shows that the highest values of recycling are limited by the coexistence of two necessary mechanisms: (1) the availability of sufficient soil moisture and (2) the occurrence of appropriate synoptic configurations favoring the development of convective regimes. The analyzed surplus of rainfall in spring has a critical impact on agriculture over large semiarid regions of the interior of Iberia.

Assessment of the ensembles regional climate models in the representation of precipitation variability and extremes over Portugal

A new data set of daily gridded observations of precipitation, computed from over 400 stations in Portugal, is used to assess the performance of 12 regional climate models at 25 km resolution, from the ENSEMBLES set, all forced by ERA-40 boundary conditions, for the 1961-2000 period. Standard point error statistics, calculated from grid point and basin aggregated data, and precipitation related climate indices are used to analyze the performance of the different models in representing the main spatial and temporal features of the regional climate, and its extreme events. As a whole, the ENSEMBLES models are found to achieve a good representation of those features, with good spatial correlations with observations. There is a small but relevant negative bias in precipitation, especially in the driest months, leading to systematic errors in related climate indices. The underprediction of precipitation occurs in most percentiles, although this deficiency is partially corrected at the basin level. Interestingly, some of the conclusions concerning the performance of the models are different of what has been found for the contiguous territory of Spain; in particular, ENSEMBLES models appear too dry over Portugal and too wet over Spain. Finally, models behave quite differently in the simulation of some important aspects of local climate, from the mean climatology to high precipitation regimes in localized mountain ranges and in the subsequent drier regions.