1 resultado para Autosomal recessive inheritance
em Repositório Científico do Instituto Politécnico de Lisboa - Portugal
Filtro por publicador
- KUPS-Datenbank - Universität zu Köln - Kölner UniversitätsPublikationsServer (1)
- University of Cagliari UniCA Eprints (1)
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Aberdeen University (2)
- Aberystwyth University Repository - Reino Unido (1)
- Academic Research Repository at Institute of Developing Economies (3)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (8)
- Aquatic Commons (2)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (3)
- Archive of European Integration (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (9)
- Aston University Research Archive (4)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital da Câmara dos Deputados (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (19)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (22)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (15)
- Bioline International (5)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (116)
- Boston University Digital Common (6)
- Brock University, Canada (2)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- CaltechTHESIS (2)
- Cambridge University Engineering Department Publications Database (4)
- CentAUR: Central Archive University of Reading - UK (20)
- Center for Jewish History Digital Collections (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (45)
- CORA - Cork Open Research Archive - University College Cork - Ireland (6)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (12)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (3)
- Digital Commons - Michigan Tech (1)
- Digital Commons at Florida International University (1)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (18)
- Duke University (13)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (17)
- FUNDAJ - Fundação Joaquim Nabuco (4)
- Greenwich Academic Literature Archive - UK (3)
- Harvard University (2)
- Helda - Digital Repository of University of Helsinki (38)
- Hospitais da Universidade de Coimbra (3)
- Indian Institute of Science - Bangalore - Índia (37)
- Infoteca EMBRAPA (1)
- Institutional Repository of Leibniz University Hannover (1)
- Instituto Gulbenkian de Ciência (3)
- Instituto Nacional de Saúde de Portugal (4)
- Instituto Politécnico do Porto, Portugal (2)
- Massachusetts Institute of Technology (1)
- National Center for Biotechnology Information - NCBI (67)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (3)
- Portal de Revistas Científicas Complutenses - Espanha (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (98)
- Queensland University of Technology - ePrints Archive (107)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (2)
- Repositorio Academico Digital UANL (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório Científico do Instituto Politécnico de Santarém - Portugal (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (3)
- Repositório Institucional da Universidade de Aveiro - Portugal (4)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (53)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- School of Medicine, Washington University, United States (2)
- Scielo España (2)
- South Carolina State Documents Depository (2)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (10)
- Universidad Politécnica de Madrid (1)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (11)
- Universidade Federal do Pará (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (5)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (10)
- Université de Montréal (1)
- Université de Montréal, Canada (18)
- Université Laval Mémoires et thèses électroniques (1)
- University of Canberra Research Repository - Australia (2)
- University of Connecticut - USA (1)
- University of Michigan (37)
- University of Queensland eSpace - Australia (23)
Resumo:
Cellular polarity concerns the spatial asymmetric organization of cellular components and structures. Such organization is important not only for biological behavior at the individual cell level, but also for the 3D organization of tissues and organs in living organisms. Processes like cell migration and motility, asymmetric inheritance, and spatial organization of daughter cells in tissues are all dependent of cell polarity. Many of these processes are compromised during aging and cellular senescence. For example, permeability epithelium barriers are leakier during aging; elderly people have impaired vascular function and increased frequency of cancer, and asymmetrical inheritance is compromised in senescent cells, including stem cells. Here, we review the cellular regulation of polarity, as well as the signaling mechanisms and respective redox regulation of the pathways involved in defining cellular polarity. Emphasis will be put on the role of cytoskeleton and the AMP-activated protein kinase pathway. We also discuss how nutrients can affect polarity-dependent processes, both by direct exposure of the gastrointestinal epithelium to nutrients and by indirect effects elicited by the metabolism of nutrients, such as activation of antioxidant response and phase-II detoxification enzymes through the transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2). In summary, cellular polarity emerges as a key process whose redox deregulation is hypothesized to have a central role in aging and cellular senescence.