Acompanhamento da constru����o de uma moradia unifamiliar

Relat��rio de Est��gio para obten����o do grau de Mestre em Engenharia Civil na ��rea de Especializa����o em Edifica����es

Density measurements of compressed dipropyl, dibutul, bis (2-ethylhexyl) adipates from (293 to 373K) at pressures up to about 68MPa

The article reports density measurements of dipropyl (DPA), dibutyl (DBA) and bis(2-ethylhexyl) (DEHA) adipates, using a vibrating U-tube densimeter, model DMA HP, from Anton Paar GmbH. The measurements were performed in the temperature range (293 to 373) K and at pressures up to about 68 MPa, except for DPA for which the upper limits were 363 K and 65 MPa, respectively. The density data for each liquid was correlated with the temperature and pressure using a modified Tait equation. The expanded uncertainty of the present density results is estimated as 0.2% at a 95% confidence level. No literature density data at pressures higher than 0.1 MPa could be found. DEHA literature data at atmospheric pressure agree with the correlation of the present measurements, in the corresponding temperature range, within +/- 0.11%. The isothermal compressibility and the isobaric thermal expansion were calculated by differentiation of the modified Tait correlation equation. These two parameters were also calculated for dimethyl adipate (DMA), from density data reported in a previous work. The uncertainties of isothermal compressibility and the isobaric thermal expansion are estimated to be less than +/- 1.7% and +/- 1.1%, respectively, at a 95% confidence level. Literature data of isothermal compressibility and isobaric thermal expansivity for DMA have an agreement within +/- 1% and +/- 2.4%, respectively, with results calculated in this work. (C) 2014 Elsevier B.V. All rights reserved.

Design, synthesis and biologival evaluation of novel isoniazid derivatives with potente antitubercular activity

The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has been driving the scientific community to urgently search for new and efficient antitubercular drugs. Despite the various drugs currently under evaluation, isoniazid is still the key and most effective component in all multi-therapeutic regimens recommended by the WHO. This paper describes the QSAR-oriented design, synthesis and in vitro antitubercular activity of several potent isoniazid derivatives (isonicotinoyl hydrazones and isonicotinoyl hydrazides) against H37Rv and two resistant Mtb strains. QSAR studies entailed RFs and ASNNs classification models, as well as MLR models. Strict validation procedures were used to guarantee the models' robustness and predictive ability. Lipophilicity was shown not to be relevant to explain the activity of these derivatives, whereas shorter N-N distances and lengthy substituents lead to more active compounds. Compounds I, 2, 4, 5 and 6, showed measured activities against H37Rv higher than INH (i.e., MIC <= 0.28 mu M), while compound 9 exhibited a six fold decrease in MIC against the katG (S315T) mutated strain, by comparison with INH (Le., 6.9 vs. 43.8 mu M). All compounds were ineffective against H37Rv(INH) (Delta katG), a strain with a full deletion of the katG gene, thus corroborating the importance of KatG in the activation of INH-based compounds. The most potent compounds were also shown not to be cytotoxic up to a concentration 500 times higher than MIC. (C) 2014 Elsevier Masson SAS. All rights reserved.

Tris(2-Ethylhexyl) trimellitate (TOTM) a potential reference fluid for high viscosity. Part I: viscosity measurements at temperatures from (303 to 373)K and pressures up to 65MPa, using a novel vibrating-wire instrument

No literature data above atmospheric pressure could be found for the viscosity of TOTIVI. As a consequence, the present viscosity results could only be compared upon extrapolation of the vibrating wire data to 0.1 MPa. Independent viscosity measurements were performed, at atmospheric pressure, using an Ubbelohde capillary in order to compare with the vibrating wire results, extrapolated by means of the above mentioned correlation. The two data sets agree within +/- 1%, which is commensurate with the mutual uncertainty of the experimental methods. Comparisons of the literature data obtained at atmospheric pressure with the present extrapolated vibrating-wire viscosity measurements have shown an agreement within +/- 2% for temperatures up to 339 K and within +/- 3.3% for temperatures up to 368 K. (C) 2014 Elsevier B.V. All rights reserved.

Tris(2-Ethylhexyl) trimellitate (TOTM) a potential reference fluid for high viscosity. Part II: density measurements at temperatures from (293 to 373)K and pressures up to 85MPa

In Part I of the present work we describe the viscosity measurements performed on tris(2-ethylhexyl) trimellitate or 1,2,4-benzenetricarboxylic acid, tris(2-ethylhexyl) ester (TOTM) up to 65 MPa and at six temperatures from (303 to 373)K, using a new vibrating-wire instrument. The main aim is to contribute to the proposal of that liquid as a potential reference fluid for high viscosity, high pressure and high temperature. The present Part II is dedicated to report the density measurements of TOTM necessary, not only to compute the viscosity data presented in Part I, but also as complementary data for the mentioned proposal. The present density measurements were obtained using a vibrating U-tube densimeter, model DMA HP, using model DMA5000 as a reading unit, both instruments from Anton Paar GmbH. The measurements were performed along five isotherms from (293 to 373)K and at eleven different pressures up to 68 MPa. As far as the authors are aware, the viscosity and density results are the first, above atmospheric pressure, to be published for TOTM. Due to TOTM's high viscosity, its density data were corrected for the viscosity effect on the U-tube density measurements. This effect was estimated using two Newtonian viscosity standard liquids, 20 AW and 200 GW. The density data were correlated with temperature and pressure using a modified Tait equation. The expanded uncertainty of the present density results is estimated as +/- 0.2% at a 95% confidence level. Those results were correlated with temperature and pressure by a modified Tait equation, with deviations within +/- 0.25%. Furthermore, the isothermal compressibility, K-T, and the isobaric thermal expansivity, alpha(p), were obtained by derivation of the modified Tait equation used for correlating the density data. The corresponding uncertainties, at a 95% confidence level, are estimated to be less than +/- 1.5% and +/- 1.2%, respectively. No isobaric thermal expansivity and isothermal compressibility for TOTM were found in the literature. (C) 2014 Elsevier B.V. All rights reserved.

Brincadeiras entre as crian��as no jardim de inf��ncia

Relat��rio da Pr��tica Profissional Supervisionada Mestrado em Educa����o Pr��-Escolar

Linux based mobile: operating systems

Trabalho de Projeto para obten����o do grau de Mestre em Engenharia Inform��tica e de Computadores

Representa����es: janelas para a compreens��o do racioc��nio estat��stico de crian��as de 5 e 6 anos

Este artigo apresenta parte de um estudo que se encontra a decorrer e que visa compreender como se caracteriza o racioc��nio estat��stico de crian��as de 5 e 6 anos. O artigo apresenta a interpreta����o do racioc��nio estat��stico revelado pelas crian��as atrav��s da an��lise das suas representa����es. Come��amos por discutir teoricamente o conceito de racioc��nio estat��stico, os princ��pios inerentes a um ambiente de aprendizagem que favore��a o seu desenvolvimento e o papel das representa����es, especificando depois as caracter��sticas do trabalho em Organiza����o e Tratamento de Dados na educa����o pr��-escolar. O estudo segue uma abordagem de natureza qualitativa sob um paradigma interpretativo e a recolha de dados realizou-se em 2015 atrav��s da observa����o participante e da an��lise documental. Os resultados preliminares aqui apresentados sugerem que a maioria do grupo de crian��as reconhece as diferentes formas de representa����o dos dados, identifica os seus nomes e sabe explicar as diferentes representa����es. No ��mbito de um pequeno projeto de investiga����o estat��stica, as crian��as atenderam ��s suas diferentes fases, mostrando-se capazes de representar e interpretar dados recolhidos por si. Algumas das crian��as preocuparam-se em organizar os dados no momento da sua recolha, classificando-os, sendo que uma delas organizou os dados, de modo espont��neo, numa tabela de frequ��ncias. As crian��as evidenciaram um racioc��nio estat��stico sobre os dados e sobre a sua representa����o.

Approaches to tuberculosis mucosal vaccine development using nanoparticles and microparticles: a review

Next-generation vaccines for tuberculosis should be designed to prevent the infection and to achieve sterile eradication of Mycobacterium tuberculosis. Mucosal vaccination is a needle-free vaccine strategy that provides protective immunity against pathogenic bacteria and viruses in both mucosal and systemic compartments, being a promising alternative to current tuberculosis vaccines. Micro and nanoparticles have shown great potential as delivery systems for mucosal vaccines. In this review, the immunological principles underlying mucosal vaccine development will be discussed, and the application of mucosal adjuvants and delivery systems to the enhancement of protective immune responses at mucosal surfaces will be reviewed, in particular those envisioned for oral and nasal routes of administration. An overview of the essential vaccine candidates for tuberculosis in clinical trials will be provided, with special emphasis on the potential different antigens and immunization regimens.

Funcionalidade e aptid��o f��sica funcional em idosos independentes residentes na comunidade no concelho de Loures

Objectivo do estudo - Caracterizar a aptid��o f��sica funcional e outros par��metros da funcionalidade em idosos residentes na comunidade. Relev��ncia do estudo - A popula����o portuguesa apresenta um risco elevado de decl��nio funcional e fragilidade. Esta tend��ncia, em conjunto um ��ndice de envelhecimento crescente, coloca um grande desafio �� sociedade, nomeadamente a n��vel econ��mico, mas sobretudo no que se refere ao estado de sa��de dos idosos, tendo a fisioterapia um papel importante na preven����o do decl��nio funcional e na manuten����o da capacidade funcional destes indiv��duos.

Colabora����o na realiza����o da espirometria numa popula����o de idosos: estudo GERIA

A espirometria �� o m��todo de elei����o para a identifica����o de altera����es ventilat��rias, por��m �� pouco utilizada em idosos pelo fato de habitualmente se considerar que estes n��o conseguem colaborar. Este estudo tem como objetivo avaliar a colabora����o na realiza����o da espirometria antes e ap��s administra����o de broncodilatador numa popula����o de idosos residente num lar de Lisboa.

Classifica����o GOLD e sintomas respirat��rios em idosos: estudo GERIA

A Europa assiste ao envelhecimento da popula����o, onde a doen��a respirat��ria assume relev��ncia. Com o aumento da idade, da exposi����o �� polui����o ambiental e do tabagismo, a preval��ncia da Doen��a Pulmonar Obstrutiva Cr��nica (DPOC) tende a ser elevada, nomeadamente na popula����o idosa. A idade avan��ada poder�� associar-se com uma menor percep����o de sintomas, pelo que a espirometria ser�� ��til nesta faixa et��ria. Objetivo do estudo - Descrever o resultado da espirometria com prova de broncodilata����o, de acordo com os crit��rios GOLD e preval��ncia de sintomas respirat��rios dos idosos residentes num lar de Lisboa.

Perfil espirom��trico e sintomas respirat��rios numa amostra de idosos sem hist��ria de doen��a respirat��ria: estudo GERIA

O sistema respirat��rio sofre altera����es inerentes ao envelhecimento que, aliadas �� exposi����o ambiental e �� carga tab��gica contribuem para um maior decl��nio da fun����o respirat��ria. Os testes de fun����o respirat��ria (e.g. espirometria) contribuem para uma melhor identifica����o altera����es ventilat��rias nas vias a��reas, tendo em conta que idade avan��ada poder�� ser um fator para m�� perce����o de sintomas. Objetivo do estudo - Caracterizar o perfil espirom��trico e os sintomas respirat��rios em idosos sem hist��ria de doen��a respirat��ria, residentes num lar de Lisboa.

Sarcop��nia, equil��brio e risco de queda em idosos independentes residentes na comunidade

O aumento do risco de queda na popula����o idosa �� um problema que se coloca atualmente aos sistemas de sa��de. Na sua origem est��o as altera����es associadas ao envelhecimento, nomeadamente as altera����es de equil��brio, a fraqueza muscular, a fragilidade, entre outras. A sarcop��nia, que se caracteriza por diminui����o da massa muscular e da for��a muscular �� uma das consequ��ncias do envelhecimento. Recentemente, a sarcop��nia tem sido associada a aumento de risco de queda na popula����o idosa. Ao mesmo tempo, a investiga����o tem mostrado que a for��a de preens��o est�� associada �� for��a dos membros e que constitui um marcador cl��nico para o risco de incapacidade, tendo sido identificados valores de corte para definir sarcop��nia atrav��s da for��a de preens��o. Objetivo do estudo - O objetivo deste estudo foi caracterizar a for��a muscular dos membros inferiores, a mobilidade, a for��a de preens��o e o risco de queda em idosos residentes na comunidade e averiguar poss��veis associa����es entre estas vari��veis.

Caracteriza����o morfo-funcional das cavidades card��acas por ecocardiografia transtor��cica em jovens atletas de gin��stica art��stica de competi����o

Sabe-se que em resposta �� pr��tica de atividade f��sica intensa e prolongada surgem adapta����es morfol��gicas e funcionais a n��vel cardiovascular. Por��m, estas adapta����es fisiol��gicas podem ser confundidas com altera����es patol��gicas, por isso, �� importante fazer a distin����o entre estes dois tipos de altera����es o mais cedo poss��vel. Este estudo teve como objetivo caracterizar, por ecocardiografia transtor��cica, a morfologia e fun����o card��aca em jovens atletas de gin��stica art��stica de competi����o.