Success factors of regional airports: the case of Oporto airport

Oporto Airport (OPO) is a success story among European regional airports. This success is expressed, among other ways, in the rapid expansion of routes and the strong growth in demand, as well as in the recognition of the airport’s quality by its users. Over the past decade, the volume of traffic increased by almost 3.4 million passengers, from the 2.6 million recorded in 2002 to over 6 million in 2012. In this paper, we analyse some of the factors that influenced the success of Oporto Airport, namely the expansion of capacity and improvements to infrastructure, the increase in the number of routes and the increased demand in response to the new capacities of this airport-airlines set. Particular emphasis is given to the role of low cost carriers (LCC) in the growth of Oporto Airport and to strategies of attracting more traffic. Some of the main opportunities and challenges that this airport will face in the coming years are also discussed.

The need for standardized tests to evaluate the reliability of data transport in wireless medical systems

Wireless medical systems are comprised of four stages, namely the medical device, the data transport, the data collection and the data evaluation stages. Whereas the performance of the first stage is highly regulated, the others are not. This paper concentrates on the data transport stage and argues that it is necessary to establish standardized tests to be used by medical device manufacturers to provide comparable results concerning the communication performance of the wireless networks used to transport medical data. Besides, it suggests test parameters and procedures to be used to produce comparable communication performance results.

Targeting lactate transport suppresses in vivo breast tumour growth

Background: Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as “Warburg effect”. Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated with higher cell proliferation, migration, invasion, angiogenesis and increased cell survival. Previously, we have described MCT1 up-regulation in breast carcinoma samples and demonstrated the importance of in vitro MCT inhibition. In this study, we performed siRNA knockdown of MCT1 and MCT4 in basal-like breast cancer cells in both normoxia and hypoxia conditions to validate the potential of lactate transport inhibition in breast cancer treatment. Results: The effect of MCT knockdown was evaluated on lactate efflux, proliferation, cell biomass, migration and invasion and induction of tumour xenografts in nude mice. MCT knockdown led to a decrease in in vitro tumour cell aggressiveness, with decreased lactate transport, cell proliferation, migration and invasion and, importantly, to an inhibition of in vivo tumour formation and growth. Conclusions: This work supports MCTs as promising targets in cancer therapy, demonstrates the contribution of MCTs to cancer cell aggressiveness and, more importantly, shows, for the first time, the disruption of in vivo breast tumour growth by targeting lactate transport.