Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

Electroactivematerials can be taken to advantage for the development of sensors and actuators as well as for novel tissue engineering strategies. Composites based on poly(vinylidenefluoride),PVDF,have been evaluated with respect to their biological response. Cell viability and proliferation were performed in vitro both with Mesenchymal Stem Cells differentiated to osteoblasts and Human Fibroblast Foreskin 1. In vivo tests were also performed using 6-week-old C57Bl/6 mice. It was concluded that zeolite and clay composites are biocompatible materials promoting cell response and not showing in vivo pro-inflammatory effects which renders both of them attractive for biological applications and tissue engineering, opening interesting perspectives to development of scaffolds from these composites. Ferrite and silver nanoparticle composites decrease osteoblast cell viability and carbon nanotubes decrease fibroblast viability. Further, carbon nanotube composites result in a significant increase in local vascularization accompanied an increase of inflammatory markers after implantation.

PROGRAMA PARA A JUSTIÇA PORTUGUESA

Há a verdade, há a mentira e há as estatísticas. Muitas outras medidas poderiam ser alvitradas, mas estas são algumas das ideias fundamentais para um programa de Governo que visa uma Justiça humanista, na qual o Ser Humano, organizado ou individual, é o centro da questão. A Justiça portuguesa também não pode ser uma competição entre a cor-de-laranja e o rosa, vermelho, azul ou qualquer outra cor, como amarelo, cinzento, castanho, entre outras. A Justiça portuguesa deve fazer-se sentir e respeitar. Não é mentira se dissermos que temos entre os melhores Magistrados do mundo, entre os melhores Advogados e Solicitadores do mundo, entre os melhores Funcionários Judiciais, Conservadores, Notários e outros Auxiliares de Justiça, entre os melhores polícias e investigadores do mundo. Bem hajas, Portugal, pois és capaz de muito mais e melhor. § There is the fact there are lies and there are statistics. Many other measures could be tell, but these are some of the key ideas for a government program aimed at a humanistic Justice, in which the human being organized or individual, is the heart of the matter. The Portuguese Justice can not be a competition between the pink-orange and pink, red, blue or any other color, such as yellow, gray, brown, and others. The Portuguese Justice must be felt and respect. It's not a lie if we say we have among the best Magistrates of the world, among the best Lawyers and Solicitors of the world, among the best Judicial Officers, Conservatives, notaries and other auxiliaries of Justice, police and among the best researchers in the world. Well wilt, Portugal, for you are capable of much more and better.