Chronic stress disrupts neural coherence between cortico-limbic structures

Chronic stress impairs cognitive function, namely on tasks that rely on the integrity of cortico-limbic networks. To unravel the functional impact of progressive stress in cortico-limbic networks we measured neural activity and spectral coherences between the ventral hippocampus (vHIP) and the medial prefrontal cortex (mPFC) in rats subjected to short term stress (STS) and chronic unpredictable stress (CUS). CUS exposure consistently disrupted the spectral coherence between both areas for a wide range of frequencies, whereas STS exposure failed to trigger such effect. The chronic stress-induced coherence decrease correlated inversely with the vHIP power spectrum, but not with the mPFC power spectrum, which supports the view that hippocampal dysfunction is the primary event after stress exposure. Importantly, we additionally show that the variations in vHIP-to-mPFC coherence and power spectrum in the vHIP correlated with stress-induced behavioral deficits in a spatial reference memory task. Altogether, these findings result in an innovative readout to measure, and follow, the functional events that underlie the stress-induced reference memory impairments.

A importância do ensino do direito penal-criminal

“Portugal manteve, em 2013, o 33.º lugar no Índice de Perceção da Corrupção da organização Transparência Internacional, mas perdeu pontuação”. E: “Na última década, o país no mundo que mais se depreciou em termos de transparência foi justamente Portugal”, “enfatizou o vice-presidente da associação Transparência e Integridade, Paulo Morais”. Abstract: "Portugal maintained in 2013, the 33 place in the Perception Index of Transparency International Corruption, but lost points." And: "In the last decade, the country in the world that most depreciated in terms of transparency was precisely Portugal", "emphasized the Vice President of Transparency and Integrity association, Paulo Morais."