A brief survey on online analysis of movement data

The increasing availability of mobility data and the awareness of its importance and value have been motivating many researchers to the development of models and tools for analyzing movement data. This paper presents a brief survey of significant research works about modeling, processing and visualization of data about moving objects. We identified some key research fields that will provide better features for online analysis of movement data. As result of the literature review, we suggest a generic multi-layer architecture for the development of an online analysis processing software tool, which will be used for the definition of the future work of our team.

Recensão do livro Abuso de Informação, Manipulação do Mercado § Responsabilidade Penal das Pessoas Colectivas, 4ª Edição Revista e Ampliada, 2015

Os crimes de abuso de informação privilegiada e manipulação do mercado estão em relação com a responsabilidade penal das pessoas colectivas como os bancos e com a chamada globalização. § The crimes of insider trading and market manipulation abuse are in relation to the criminal liability of legal persons such as banks and so-called globalization.

Lições de Direito e Processo Penal, Solicitadoria, 3º Ano, Escola Superior de Gestão do Instituto Politécnico do Cávado e do Ave, Ano Lectivo de 2014/2015

Lições de Direito e Processo Penal, Solicitadoria, 3º Ano, Escola Superior de Gestão do Instituto Politécnico do Cávado e do Ave, Ano Lectivo de 2014/2015 § Lessons of Law and Criminal Procedure, Solicitors, 3rd Year, School of Management of the Polytechnic Institute of Cávado and Ave, Academic Year 2014/2015

Lições de Direito Económico e Financeiro, Gestão Bancária e Seguros, 1º Ano, Escola Superior de Gestão do Instituto Politécnico do Cávado e do Ave, Ano Lectivo de 2014/2015

Lições de Direito Económico e Financeiro, Gestão Bancária e Seguros, 1º Ano, Escola Superior de Gestão do Instituto Politécnico do Cávado e do Ave, Ano Lectivo de 2014/2015 § Lessons from the Economic and Financial Law, Banking and Insurance Management, 1st Year, School of Management of the Polytechnic Institute of Cávado and Ave, Academic Year 2014/2015.

Lições de Direito dos Valores Mobiliários, Mestrado em Auditoria, Escola Superior de Gestão do Instituto Politécnico do Cávado e do Ave, Ano Lectivo de 2014/2015

Lições de Direito dos Valores Mobiliários, Mestrado em Auditoria, Escola Superior de Gestão do Instituto Politécnico do Cávado e do Ave, Ano Lectivo de 2014/2015 § Lessons Securities Law, Master in Audit, School of Management of the Polytechnic Institute of Cávado and Ave, Academic Year 2014/2015

Lições de Direito e Procedimento Tributário, Fiscalidade, Escola Superior de Gestão do Instituto Politécnico do Cávado e do Ave, Ano Lectivo de 2014/2015

Lições de Direito e Procedimento Tributário, Fiscalidade, Escola Superior de Gestão do Instituto Politécnico do Cávado e do Ave, Ano Lectivo de 2014/2015 § Lessons in Law and Tax Procedure, Taxation, School of Management of the Polytechnic Institute of Cávado and Ave, Academic Year 2014/2015

Targeting lactate transport suppresses in vivo breast tumour growth

Background: Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as “Warburg effect”. Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated with higher cell proliferation, migration, invasion, angiogenesis and increased cell survival. Previously, we have described MCT1 up-regulation in breast carcinoma samples and demonstrated the importance of in vitro MCT inhibition. In this study, we performed siRNA knockdown of MCT1 and MCT4 in basal-like breast cancer cells in both normoxia and hypoxia conditions to validate the potential of lactate transport inhibition in breast cancer treatment. Results: The effect of MCT knockdown was evaluated on lactate efflux, proliferation, cell biomass, migration and invasion and induction of tumour xenografts in nude mice. MCT knockdown led to a decrease in in vitro tumour cell aggressiveness, with decreased lactate transport, cell proliferation, migration and invasion and, importantly, to an inhibition of in vivo tumour formation and growth. Conclusions: This work supports MCTs as promising targets in cancer therapy, demonstrates the contribution of MCTs to cancer cell aggressiveness and, more importantly, shows, for the first time, the disruption of in vivo breast tumour growth by targeting lactate transport.