1 resultado para seventh day adventist church
em Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP)
Filtro por publicador
- JISC Information Environment Repository (3)
- Rhode Island School of Design (1)
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Aberystwyth University Repository - Reino Unido (1)
- Aquatic Commons (15)
- Archive of European Integration (28)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (5)
- Biblioteca de Teses e Dissertações da USP (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (4)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (1)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (8)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (1)
- Boston University Digital Common (47)
- Brock University, Canada (63)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- CaltechTHESIS (1)
- Cambridge University Engineering Department Publications Database (3)
- CentAUR: Central Archive University of Reading - UK (89)
- Center for Jewish History Digital Collections (12)
- Chapman University Digital Commons - CA - USA (3)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (9)
- Cochin University of Science & Technology (CUSAT), India (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (6)
- Dalarna University College Electronic Archive (3)
- Deakin Research Online - Australia (156)
- Digital Archives@Colby (7)
- Digital Commons - Montana Tech (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons @ Winthrop University (8)
- Digital Commons at Florida International University (2)
- DigitalCommons@The Texas Medical Center (1)
- DRUM (Digital Repository at the University of Maryland) (2)
- Duke University (2)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (6)
- Harvard University (1)
- Helda - Digital Repository of University of Helsinki (17)
- Indian Institute of Science - Bangalore - Índia (4)
- Instituto Politécnico do Porto, Portugal (7)
- Ministerio de Cultura, Spain (15)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (3)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (117)
- Queensland University of Technology - ePrints Archive (104)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (2)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (54)
- Research Open Access Repository of the University of East London. (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- School of Medicine, Washington University, United States (6)
- South Carolina State Documents Depository (5)
- Universidad Autónoma de Nuevo León, Mexico (5)
- Universidad del Rosario, Colombia (5)
- Universidad Politécnica de Madrid (2)
- Universidade Federal do Pará (5)
- Universidade Federal do Rio Grande do Norte (UFRN) (3)
- Universidade Metodista de São Paulo (8)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (3)
- Université de Lausanne, Switzerland (2)
- Université de Montréal, Canada (14)
- University of Michigan (94)
- University of Southampton, United Kingdom (7)
- University of Washington (1)
- WestminsterResearch - UK (5)
- Worcester Research and Publications - Worcester Research and Publications - UK (6)
Resumo:
The increasing resistance of malarial parasites to almost all available drugs calls for the identification of new compounds and the detection of novel targets. Here, we establish the antimalarial activities of risedronate, one of the most potent bisphosphonates clinically used to treat bone resorption diseases, against blood stages of Plasmodium falciparum (50% inhibitory concentration [IC(50)] of 20.3 +/- 1.0 mu M). We also suggest a mechanism of action for risedronate against the intraerythrocytic stage of P. falciparum and show that protein prenylation seems to be modulated directly by this drug. Risedronate inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins, an effect not observed for the transfer of geranylgeranyl pyrophosphate. Our in vivo experiments further demonstrate that risedronate leads to an 88.9% inhibition of the rodent parasite Plasmodium berghei in mice on the seventh day of treatment; however, risedronate treatment did not result in a general increase of survival rates.