The role of convective parameterization in the simulation of a cyclone over the South Atlantic

Numerical simulations are carried out to examine the role of the Kuo and Kain-Fritsch (KF) cumulus parameterization schemes and dry dynamics on a cyclone development, in a weak baroclinic atmosphere, over subtropical South Atlantic Ocean. The initial phase of the cyclone development is investigated with a coarse horizontal mesh (75 km) and when the cyclone reaches the mature stage two different horizontal resolutions are used (75 and 25 km). The best performance simulation for the cyclone initial phase occurs when the Kuo convective scheme is applied, and this may be attributed to a greater diabatic warming in the troposphere. On the other hand, the dry simulation is not capable of simulating the correct location and intensity of the cyclone in its initial phase. During the mature phase, a cyclone over deepening occurs in the Kuo scheme experiment associated with larger latent heat release in a deep vertical column. The presence of downdraft currents in the KF scheme, which acts to cool and dry the lower levels, is essential to stabilize the atmosphere and to reproduce the nearest observation cyclone deepening rate. The largest cyclone deepening is found in the Kuo scheme high resolution experiment. This suggests that the KF convective scheme is less sensitive to the horizontal grid resolution. It was also revealed that the diabatic processes are crucial to simulate the observed features of this marine cyclone over subtropical region.

Donor bone marrow cells play a role in the prevention of accelerated graft rejection induced by semi-allogeneic spleen cells in transplantation

Spleen or spleen plus bone marrow cells from (BALB/c x C57Bl/6)F1 donors were transferred into BALB/c recipients 21 days before skin or cardiac transplantation. Prolonged graft survival was observed on recipients treated with the mixture of donor-derived cells as compared to those treated with spleen cells alone. We evaluated the expression of CD45RB and CD44 by splenic CD4(+) and CD8(+) T cells 7 and 21 days after donor cell transfer. The populations of CD8(+)CD45RB(low) and CD8(+)CD44(high) cells were significantly decreased in mice pre-treated with donor spleen and bone marrow cells as compared to animals treated with spleen cells only, although these cells expanded in both groups when compared to an earlier time-point. No differences were observed regarding CD4+ T cell population when recipients of donor-derived cells were compared. An enhanced production of IL-10 was observed seven days after transplantation in the supernatants of spleen cell cultures of mice treated with spleen and bone marrow cells. Taken together these data suggest that donor-derived bone marrow cells modulate the sensitization of the recipient by semi-allogeneic spleen cells in part by delaying the generation of activated/memory CD8(+) T cells leading to enhanced graft survival. (c) 2007 Elsevier B.V. All rights reserved.

A Time Efficient Optical Model for GATE Simulation of a LYSO Scintillation Matrix Used in PET Applications

A time efficient optical model is proposed for GATE simulation of a LYSO scintillation matrix coupled to a photomultiplier. The purpose is to avoid the excessively long computation time when activating the optical processes in GATE. The usefulness of the model is demonstrated by comparing the simulated and experimental energy spectra obtained with the dual planar head equipment for dosimetry with a positron emission tomograph ( DoPET). The procedure to apply the model is divided in two steps. Firstly, a simplified simulation of a single crystal element of DoPET is used to fit an analytic function that models the optical attenuation inside the crystal. In a second step, the model is employed to calculate the influence of this attenuation in the energy registered by the tomograph. The use of the proposed optical model is around three orders of magnitude faster than a GATE simulation with optical processes enabled. A good agreement was found between the experimental and simulated data using the optical model. The results indicate that optical interactions inside the crystal elements play an important role on the energy resolution and induce a considerable degradation of the spectra information acquired by DoPET. Finally, the same approach employed by the proposed optical model could be useful to simulate a scintillation matrix coupled to a photomultiplier using single or dual readout scheme.