2 resultados para Intercepção de Comunicações

em Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP)


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O Grupo Poéticas Digitais foi criado em 2002, no Departamento de Artes Plásticas da ECA-USP, com a intenção de gerar um núcleo multidisciplinar, promovendo o desenvolvimento de projetos experimentais e a reflexão sobre o impacto das novas tecnologias no campo das artes. O Grupo é um desdobramento do projeto wAwRwT, iniciado em 1995 por Gilbertto Prado e tem como participantes professores, artistas, pesquisadores e estudantes. O objetivo deste texto é apresentar algumas experimentações recentes de projetos poéticos como Desluz, de 2009/2010, e Amoreiras, de 2010.

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The connexin 32 (Cx32) is a protein that forms the channels that promote the gap junction intercellular communication (GJIC) in the liver, allowing the diffusion of small molecules through cytosol from cell-to-cell. Hepatic fibrosis is characterized by a disruption of normal tissue architeture by cellular lesions, and may alter the GJIC. This work aimed to study the expression and distribution of Cx32 in liver fibrosis induced by the oral administration of dimethylnitrosamine in female Wistar rats. The necropsy of the rats was carried out after five weeks of drug administration. They presented a hepatic fibrosis state. Sections from livers with fibrosis and from control livers were submitted to immunohistochemical, Real Time-PCR and Western-Blot analysis to Cx32. In fibrotic livers the Cxs were diffusely scattered in the cytoplasm, contrasting with the control livers, where the Cx32 formed junction plaques at the cell membrane. Also it was found a decrease in the gene expression of Cx32 without reduction in the protein quantity when compared with controls. These results suggest that there the mechanism of intercellular communication between hepatocytes was reduced by the fibrotic process, which may predispose to the occurrence of a neoplastic process, taken in account that connexins are considered tumor suppressing genes.